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master's thesis
Antimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava
Zagreb: University of Zagreb, Faculty of Science, 2023. urn:nbn:hr:217:489556
Jurišić, Matea
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Jurišić, M. (2023). Antimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:489556

Jurišić, Matea. "Antimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava." Master's thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:489556

Jurišić, Matea. "Antimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava." Master's thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:489556

Jurišić, M. (2023). 'Antimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava', Master's thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:489556

Jurišić M. Antimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2023 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:489556

M. Jurišić, "Antimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:217:489556

Metadata
TitleAntimikrobna rezistencija izolata bakterija Enterobacteriaceae iz ljudskog urogenitalnog sustava
Title (english)Antimicrobial resistance of Enterobacteriaceae isolates from human urogenital system
AuthorMatea Jurišić
MentorJasna Hrenović (mentor)
Committee memberJasna Hrenović (predsjednik povjerenstva)
Committee memberPetra Peharec Štefanić (član povjerenstva)
Committee memberPetar Kružić (član povjerenstva)
Committee memberSilvija Černi (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2023-09-27, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Antibiotici su farmakološke tvari koje zaustavljaju umnažanje bakterija, a da pri tome ne uzrokuju značajnu štetu domaćinu. Danas je rezistencija bakterija na antibiotike vrlo raširena, a razvila se ponajviše zbog neracionalne upotrebe antibiotika. Posebnu zabrinutost predstavlja sve češća pojava multiplorezistentnih izolata koji produciraju β-laktamaze proširenog spektra (ESBL). Enterobacteriaceae su heterogena skupina bakterija i česti su uzročnici infekcija mokraćnog, spolnog i probavnog sustava. Cilj istraživanja bio je pružiti uvid u antimikrobnu rezistenciju izolata bakterija Enterobacteriaceae u Hrvatskoj te utvrditi prevalenciju ESBL producirajućih izolata. Izolati bakterija Enterobacteriacae su izdvojeni iz ljudskog urogenitalnog sustava od strane djelatnika Hrvatskog zavoda za javno zdravstvo i ustupljeni su za provedbu eksperimentalnog dijela diplomskog rada. Osjetljivost izolata na antibiotike ispitana je disk-difuzijskom metodom po Kirby-Baueru i metodom dvostrukog disk-sinergijskog testa. Utvrđena je velika rezistencija Enterobacteriacae na β-laktame (ampicilin 100%, svi cefalosporini više od 90%), fluorokinolone (ciprofloksacin 77%, norfloksacin 74% ) i aminoglikozide (gentamicin 44% i amikacin 10%). Samo 10% izolata Enterobacteriaceae produciralo je ESBL.
Abstract (english)
Antibiotics are pharmacological substances that inhibit the multiplication of bacteria without causing significant harm to the host. Today, bacterial resistance to antibiotics is widespread and has mainly developed due to the irrational use of antibiotics. A particular concern is the increasingly frequent occurrence of multi-drug resistant isolates producing extended-spectrum β-lactamases (ESBL). Enterobacteriaceae are a heterogeneous group of bacteria and are common causes of urinary, sexual, and digestive system infections. The aim of the research was to provide insight into the antimicrobial resistance of Enterobacteriaceae isolates in Croatia and to determine the prevalence of ESBL-producing isolates. Enterobacteriaceae bacterial isolates were obtained from the human urogenital system by the staff of the Croatian Institute of Public Health and were provided to me for the experimental part of my thesis. The sensitivity of the isolates to antibiotics was tested using the Kirby-Bauer disk diffusion method and the double disk synergy test. A high resistance of Enterobacteriaceae to β-lactams (ampicillin 100%, all cephalosporins over 90%), fluoroquinolones (ciprofloxacin 77%, norfloxacin 74%) and aminoglycosides (gentamicin 44% and amikacin 10%) was determined. Only 10% of Enterobacteriaceae isolates produced ESBL.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:489556
Study programmeTitle: Experimental Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra eksperimentalne biologije (magistar/magistra eksperimentalne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-10-16 11:06:40