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doctoral thesis
N-GLYCOSYLATION OF IMMUNOGLOBULIN G AND TOTAL PLASMA PROTEINS IN CORONARY ARTERY DISEASE
Zagreb: University of Zagreb, Faculty of Science, 2023. urn:nbn:hr:217:709810
RADOVANI, BARBARA
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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RADOVANI, B. (2023). N-GLYCOSYLATION OF IMMUNOGLOBULIN G AND TOTAL PLASMA PROTEINS IN CORONARY ARTERY DISEASE (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:709810

RADOVANI, BARBARA. "N-GLYCOSYLATION OF IMMUNOGLOBULIN G AND TOTAL PLASMA PROTEINS IN CORONARY ARTERY DISEASE." Doctoral thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:709810

RADOVANI, BARBARA. "N-GLYCOSYLATION OF IMMUNOGLOBULIN G AND TOTAL PLASMA PROTEINS IN CORONARY ARTERY DISEASE." Doctoral thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:709810

RADOVANI, B. (2023). 'N-GLYCOSYLATION OF IMMUNOGLOBULIN G AND TOTAL PLASMA PROTEINS IN CORONARY ARTERY DISEASE', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 06 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:709810

RADOVANI B. N-GLYCOSYLATION OF IMMUNOGLOBULIN G AND TOTAL PLASMA PROTEINS IN CORONARY ARTERY DISEASE [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2023 [cited 2024 May 06] Available at: https://urn.nsk.hr/urn:nbn:hr:217:709810

B. RADOVANI, "N-GLYCOSYLATION OF IMMUNOGLOBULIN G AND TOTAL PLASMA PROTEINS IN CORONARY ARTERY DISEASE", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:217:709810

Metadata
TitleN-GLYCOSYLATION OF IMMUNOGLOBULIN G AND TOTAL PLASMA PROTEINS IN CORONARY ARTERY DISEASE
Title (croatian)N-GLIKOZILACIJA IMUNOGLOBULINA G I UKUPNIH PROTEINA PLAZME U KORONARNOJ BOLESTI SRCA
AuthorBARBARA RADOVANI
MentorIvan Gudelj (mentor)
Committee memberOlga Gornik Kljaić (predsjednik povjerenstva)
Committee memberPetra Korać (član povjerenstva)
Committee memberToma Keser (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2023-10-19, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
Coronary artery disease (CAD) is the most common cardiovascular disease (CVD), resulting from chronic inflammation of the coronary arteries due to the formation of atherosclerotic plaques, and its presence is a significant marker of adverse cardiovascular (CV) events. Previous research has linked N-glycosylation, a highly regulated posttranslational modification, to the development of atherosclerotic plaques. Therefore, the aim of this work was to determine whether N-glycosylation of total plasma proteins and, in particular, immunoglobulin G (IgG) is associated with CAD. Sex-stratified analysis of N-glycosylation of total plasma proteins and IgG revealed significant changes associated with CAD, with different patterns observed in men and women. Highly branched sialylated plasma N-glycan structures with terminal fucose were positively associated, whereas biantennary sialylated IgG N-glycan structures were negatively associated with CAD. Overall, protein N-glycosylation emerges as a significant factor in CAD, with glycan-based biomarkers showing promise for predicting cardiovascular health.
Abstract (croatian)
Koronarna bolest srca (KBS) najčešća je kardiovaskularna bolest (KVB), koja nastaje kao posljedica kronične upale koronarnih arterija uslijed stvaranja aterosklerotskih plakova, a njezina je prisutnost značajan biljeg štetnih kardiovaskularnih (KV) događaja. Prethodna su istraživanja povezala N-glikozilaciju, visoko reguliranu posttranslacijsku modifikaciju, s razvojem aterosklerotskih plakova. Stoga je cilj ovog doktorskog rada bio utvrditi je li Nglikom ukupnih proteina plazme, a posebice imunoglobulina G (IgG), povezan s KBS-om. Spolno stratificirana analiza N-glikozilacije ukupnih proteina plazme i IgG otkrila je značajne promjene povezane s KBS-om, s različitim obrascima uočenim u muškaraca i žena. Visoko razgranate sijalizirane N-glikanske strukture proteina plazme s terminalnom fukozom bile su pozitivno povezane, dok su biantenarne sijalizirane IgG N-glikanske strukture bile negativno povezane s KBS-om. Sve u svemu, N-glikozilacija proteina pojavljuje se kao značajan čimbenik u KBS-u, te biljezi temeljeni na glikanima predstavljaju potencijal za predviđanje kardiovaskularnog zdravlja.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:217:709810
Promotion2023
ProjectNumber: UIP-2019-04-5692
Title: Glikozilacija u kardiovaskularnim bolestima
Title: Glycosylation in Cardiovascular diseases
Acronym: GLYCARD
Leader: Ivan Gudelj
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: UIP
Study programmeTitle: Doctoral study
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti u području prirodnih znanosti (doktor/doktorica znanosti u području prirodnih znanosti)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-10-25 08:15:38