prikaz prve stranice dokumenta The effect of Tau protein expression on neuroligin-1-mediated synaptic plasticity in a cell model of Alzheimer's disease
Embargo period 2025-09-29
master's thesis
The effect of Tau protein expression on neuroligin-1-mediated synaptic plasticity in a cell model of Alzheimer's disease
Zagreb: University of Zagreb, Faculty of Science, 2023. urn:nbn:hr:217:301715
Horvatović, Kamelija
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Horvatović, K. (2023). The effect of Tau protein expression on neuroligin-1-mediated synaptic plasticity in a cell model of Alzheimer's disease (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:301715

Horvatović, Kamelija. "The effect of Tau protein expression on neuroligin-1-mediated synaptic plasticity in a cell model of Alzheimer's disease." Master's thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:301715

Horvatović, Kamelija. "The effect of Tau protein expression on neuroligin-1-mediated synaptic plasticity in a cell model of Alzheimer's disease." Master's thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:301715

Horvatović, K. (2023). 'The effect of Tau protein expression on neuroligin-1-mediated synaptic plasticity in a cell model of Alzheimer's disease', Master's thesis, University of Zagreb, Faculty of Science, accessed 27 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:301715

Horvatović K. The effect of Tau protein expression on neuroligin-1-mediated synaptic plasticity in a cell model of Alzheimer's disease [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2023 [cited 2024 November 27] Available at: https://urn.nsk.hr/urn:nbn:hr:217:301715

K. Horvatović, "The effect of Tau protein expression on neuroligin-1-mediated synaptic plasticity in a cell model of Alzheimer's disease", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:217:301715

Metadata
TitleThe effect of Tau protein expression on neuroligin-1-mediated synaptic plasticity in a cell model of Alzheimer's disease
Title (croatian)Utjecaj ekspresije proteina Tau na sinaptičku plastičnost posredovanu neuroliginom-1 u staničnom modelu Alzheimerove bolesti
AuthorKamelija Horvatović
MentorSusanne Wegmann (mentor)
MentorDubravka Hranilović (komentor)
Committee memberDubravka Hranilović (predsjednik povjerenstva)
Committee memberJulija Erhardt (član povjerenstva)
Committee memberMaja Matulić (član povjerenstva)
Committee memberDunja Leljak-Levanić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2023-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder characterized by the accumulation of Tau neurofibrillary tangles that correlate with cognitive and memory decline. Synaptic dysfunction and disruption of synaptic plasticity are among the earliest changes observed in the brains of patients and animal models of AD. Recent evidence suggests a potential role for neuroligin-1 during the initial stages of AD in the hippocampus. Neuroligin-1 is a postsynaptic adhesion molecule with a key role in stabilizing glutamatemediated long-term potentiation (LP) and memory formation. Despite the overlapping mechanisms, the pathological influence of Tau protein on neuroligin-1 is not yet known. The aim of this work is to investigate whether there is a direct relationship between the change in Tau protein expression and the level of expression and function changes of neuroligin-1. This pilot study implies that the overexpression of Tau protein and increased Tau phosphorylation at serine residue Ser262 are related to disruption in neuroligin1 levels in hippocampal neurons, providing valuable insight into their potential roles and interaction in early AD pathogenesis.
Abstract (croatian)
Alzheimerova bolest (AB) je progresivan, neurodegenerativni poremećaj karakteriziran nakupljanjem Tau neurofibrilarnih snopića koji koreliraju s padom kognicije i memorije. Sinaptička disfunkcija i poremećaj sinaptičke plastičnosti su među najranijim promjenama primijećenim u mozgu oboljelih i animalnim modelima AB. Nedavni dokazi ukazuju na potencijalnu ulogu neuroligina-1 tijekom početnih stadija AB u hipokampusu. Neuroligin-1 je postsinaptička adhezijska molekula s ključnom ulogom u stabilizaciji dugotrajnog potenciranja (DP) posredovanog glutamatom i formiranju pamćenja. Unatoč preklapajućim mehanizmima, još nije poznat patološki utjecaj proteina Tau na neuroligin-1. Cilj ovog rada je istražiti postoji li direktna povezanost između promjene ekspresije proteina Tau i promjena razina ekspresije i funkcije neuroligina-1. Ovo pilot istraživanje ukazuje na povezanost između povećane ekspresije proteina Tau, hiperfosforilacije proteina Tau na serinskom ostatku Ser262 i poremećenih razina neuroligina-1 u hipokampalnim neuronima, pružajući uvid u njihovu potencijalnu ulogu i interakciju u patogenezi ranog stadija AB.
Keywords
Keywords (english)
Languageenglish
URN:NBNurn:nbn:hr:217:301715
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2025-09-29
Terms of useLicence In copyright icon
Created on2023-11-15 12:23:28