prikaz prve stranice dokumenta UČINAK INHIBITORA SGLT2 NA MARKER STRESA MIOCITA (NT-proBNP) U ŠEĆERNOJ BOLESTI TIPA 2
Embargo period 2025-09-20
doctoral thesis
UČINAK INHIBITORA SGLT2 NA MARKER STRESA MIOCITA (NT-proBNP) U ŠEĆERNOJ BOLESTI TIPA 2
Zagreb: University of Zagreb, Faculty of Science, 2023. urn:nbn:hr:217:371256
Grubić Rotkvić, Petra
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Grubić Rotkvić, P. (2023). UČINAK INHIBITORA SGLT2 NA MARKER STRESA MIOCITA (NT-proBNP) U ŠEĆERNOJ BOLESTI TIPA 2 (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:371256

Grubić Rotkvić, Petra. "UČINAK INHIBITORA SGLT2 NA MARKER STRESA MIOCITA (NT-proBNP) U ŠEĆERNOJ BOLESTI TIPA 2." Doctoral thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:371256

Grubić Rotkvić, Petra. "UČINAK INHIBITORA SGLT2 NA MARKER STRESA MIOCITA (NT-proBNP) U ŠEĆERNOJ BOLESTI TIPA 2." Doctoral thesis, University of Zagreb, Faculty of Science, 2023. https://urn.nsk.hr/urn:nbn:hr:217:371256

Grubić Rotkvić, P. (2023). 'UČINAK INHIBITORA SGLT2 NA MARKER STRESA MIOCITA (NT-proBNP) U ŠEĆERNOJ BOLESTI TIPA 2', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:371256

Grubić Rotkvić P. UČINAK INHIBITORA SGLT2 NA MARKER STRESA MIOCITA (NT-proBNP) U ŠEĆERNOJ BOLESTI TIPA 2 [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2023 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:371256

P. Grubić Rotkvić, "UČINAK INHIBITORA SGLT2 NA MARKER STRESA MIOCITA (NT-proBNP) U ŠEĆERNOJ BOLESTI TIPA 2", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:217:371256

Metadata
TitleUČINAK INHIBITORA SGLT2 NA MARKER STRESA MIOCITA (NT-proBNP) U ŠEĆERNOJ BOLESTI TIPA 2
Title (english)THE EFFECT OF SGLT2 INHIBITORS ON MARKER OF MYOCYTE STRESS (NTproBNP) IN TYPE 2 DIABETES
AuthorPetra Grubić Rotkvić
MentorMaja Cigrovski Berković (mentor)
Committee memberVesna Benković (predsjednik povjerenstva)
Committee memberInes Bilić-Ćurčić (član povjerenstva)
Committee memberMatias Trbušić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2023-09-20, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
U ovoj prospektivnoj opservacijskoj studiji procjenjivani su kardiovaskularni učinci inhibitora kotransportera natrij-glukoza 2 (SGLT2) kod bolesnika sa šećernom bolesti tipa 2 u kojih je postojala loša glukoregulacija na monoterapiji metforminom te im je bila potrebna intenzifikacija terapije (SGLT2 inhibitori ili inhibitori dipeptidil-peptidaze 4). Na početku i nakon šest mjeseci dodatne terapije obavljena je krvna analiza te fizikalni i ehokardiografski pregled. Nisu nađene značajne razlike između skupina u biomarkerima miocitnog i oksidacijskog stresa, upale te krvnom tlaku, dok su se indeks tjelesne mase, trigliceridi, aspartat-aminotransferaza, mokraćna kiselina, E/E’, deceleracijsko vrijeme i sistolički tlak u plućnoj arteriji značajno snizili, a udarni volumen i indeksirani udarni volumen te lipoprotein visoke gustoće, hematokrit i hemoglobin značajno povisili u skupini na SGLT2 inhibitorima. Iz navedenog proizlazi da mehanizmi djelovanja SGLT2 inhibitora podrazumijevaju brze promjene u odnosu masnog i nemasnog tkiva, metaboličkim parametrima, zatim smanjeno srčano opterećenje te poboljšanje dijastoličkih i sistoličkih parametara srčane funkcije.
Abstract (english)
This prospective observational study evaluated the cardiovascular effects of sodium glucose cotransporter 2 inhibitors (SGLT2i) in patients with type 2 diabetes and poor glucoregulation on metformin who needed additional therapy (SGLT2i or dipeptidyl peptidase4 inhibitors in the control group). At the beginning and after six months of additional therapy, laboratory analysis, physical and echocardiographic examination were performed. There were no significant differences between the two groups in terms of biomarkers of myocyte and oxidative stress, inflammation and blood pressure. Body mass index, triglycerides, aspartate aminotransferase, uric acid, E/E’, deceleration time, and systolic pressure in the pulmonary artery significantly decreased, while stroke volume, and indexed stroke volume as well as highdensity lipoprotein, hematocrit, and hemoglobin, significantly increased in the group on SGLT2i. According to the results, SGLT2i mechanisms of action obviously comprise rapid changes in body composition and metabolic parameters, reduced cardiac load, and improvement in diastolic and systolic heart parameters.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:371256
Promotion2023
Study programmeTitle: Doctoral study
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti u području prirodnih znanosti (doktor/doktorica znanosti u području prirodnih znanosti)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2025-09-20
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Created on2023-11-15 12:40:46