The aim of this study was to investigate the combined effect of a resveratrol solution and its nanocrystals in a dose of 50 mg/kg ap p lied perorally po and the cisplatin injected intraperitoneally ( ip in a dose of 2.5 mg/kg, on days 10 and 12, and on day 15 in a dose of 5 mg/kg on the growth of the solid form of Ehrlich ascites tumor (sEAT). A suspension of EAT cells at a concentration of 1x10 6 was subcutaneously inoculated into the right thigh of Balb/C mice. The animals were randomly divided into 6 groups (n = 15) according to the applied treatment. Five animals from each group were sacrificed on the day 16 after EAT inoculation for the analysis of the number of blood vessels, the expression of hypoxia inducible factor 1 alpha ( HIF 1 α) and inducible nitric oxide synthase ( iNOS), as well as for the measurement of nitric (II ) oxide (NO) concentrations, while w e kept part of the animals (n = 10) for monitoring the parameters of tumor volume, change s in animal body weight , increase in lifespan and overall survival The results indicate that resveratrol and its nanocrystals in combination with cisplatin lead to an increase in the life span and overall survival of mice, reduce the tumor volume, which is accompanied by a decrease in the body mass of the animals. The re sveratrol solution reduced HIF 1 α expression in tumor and liver tissue, while iNOS expression was high in most of the treated groups, which indicates an antitumor effect and M1 macrophage activity. Resveratrol and its nanocrystals also showed a reduced number of blood vessels in tumor and liver tissue. We can conclude that the combined use of resveratrol and cisplatin has a positive effect in the treatment of tumors. Resveratrol and its nanocrystals show antioxidant, anti inflammatory and anti angiogenic properties, and besides acting on the tumor itself, it is possible that they reduce the toxic effect of cisplatin on the liver.