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master's thesis
Raznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u čagljeva (Canis aureus)
Zagreb: University of Zagreb, Faculty of Science, 2016. urn:nbn:hr:217:187581
Svetličić, Ida
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Svetličić, I. (2016). Raznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u čagljeva (Canis aureus) (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:187581

Svetličić, Ida. "Raznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u čagljeva (Canis aureus)." Master's thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:187581

Svetličić, Ida. "Raznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u čagljeva (Canis aureus)." Master's thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:187581

Svetličić, I. (2016). 'Raznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u čagljeva (Canis aureus)', Master's thesis, University of Zagreb, Faculty of Science, accessed 21 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:187581

Svetličić I. Raznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u čagljeva (Canis aureus) [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2016 [cited 2024 December 21] Available at: https://urn.nsk.hr/urn:nbn:hr:217:187581

I. Svetličić, "Raznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u čagljeva (Canis aureus)", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:217:187581

Metadata
TitleRaznolikost gena DQA i DQB skupine II glavnog sustava tkivne podudarnosti u čagljeva (Canis aureus)
Title (english)Variability of major histocompatibility complex class II DQA and DQB genes in the golden jackal (Canis aureus)
AuthorIda Svetličić
MentorAna Galov (mentor)
Committee memberAna Galov (predsjednik povjerenstva)
Committee memberBožena Mitić (član povjerenstva)
Committee memberIvančica Ternjej (član povjerenstva)
Committee memberMirta Tkalec (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2016-02-29, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Geni unutar glavnog sustava tkivne podudarnosti (MHC) kodiraju receptore koji su odgovorni za preradu i prikazivanje antigena limfocitima T, čime se pokreće adaptivni imunosni odgovor organizma. Veća varijabilnost genskih lokusa MHC omogućuje prepoznavanje šireg spektra antigena, pa posljedično i bolju obranu od patogena. Varijabilnost lokusa MHC održava ravnotežna selekcija, koju karakterizira veći broj raznolikih alela u populaciji. Geni MHC pokazali su se kao dobar marker za proučavanje adaptivne evolucije vrsta i populacija. Čagalj (Canis aureus) široko je rasprostranjen ali jedan od dosad najmanje istraženih pripadnika porodice pasa (Canidae). U ovom istraživanju utvrdila sam i opisala alele na lokusima DLA-DQA i DQB gena MHC skupine II u uzorku od 27 čagljeva iz istočne Europe. Pronašla sam 2 alela po lokusu, a svi su poznati iz prethodnih istraživanja. Unatoč malom broju pronađenih alela, evolucijske udaljenosti ukazuju na veliku raznolikost među njima. Potvrdila sam djelovanje ravnotežne selekcije na održavanje varijabilnosti oba istražena lokusa koristeći omjer stopa nesinonimnih i sinonimnih mutacija na čitavom nukleotidnom slijedu, kao i na pojedinim kodonima.
Abstract (english)
Genes within the major histocompatibility complex (MHC) encode receptors that are responsible for processing and presentation of antigens to T lymphocytes, which initiates the adaptive immune response of the organism. Increased variability of MHC gene loci enables identification of a broader range of antigens, and consequently a better defense against pathogens. The variability of the MHC loci is maintained by the balancing selection, which is characterized by a larger number of divergent alleles in the population. MHC genes proved to be a good marker for the study of adaptive evolution of the species and populations. Golden jackal (Canis aureus) is widespread, but so far one of the least studied members of the dog family (Canidae). In this research, I found and described the alleles of the DLA-DQA and DQB MHC class II loci in a sample of 27 jackals from Eastern Europe. I found two alleles per locus, all of which are known from previous research. Despite the small number of alleles found, evolutionary distances indicate a considerable diversity among them. I confirmed the role of balancing selection on maintaining variability of the investigated loci, using the ratio of synonymous and nonsynonymous mutations both on the entire nucleotide sequence, and the particular codons.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:187581
Study programmeTitle: Experimental Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra eksperimentalne biologije (magistar/magistra eksperimentalne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-05-12 08:46:20