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master's thesis
Interakcije 4"-benzil-makrozona i njegova kompleksa s niklom(II) s biološkim metama tehnikama STD i WaterLOGSY NMR
Zagreb: University of Zagreb, Faculty of Science, 2024. urn:nbn:hr:217:884767
Delaš, Kristina
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Delaš, K. (2024). Interakcije 4"-benzil-makrozona i njegova kompleksa s niklom(II) s biološkim metama tehnikama STD i WaterLOGSY NMR (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:884767

Delaš, Kristina. "Interakcije 4"-benzil-makrozona i njegova kompleksa s niklom(II) s biološkim metama tehnikama STD i WaterLOGSY NMR." Master's thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:884767

Delaš, Kristina. "Interakcije 4"-benzil-makrozona i njegova kompleksa s niklom(II) s biološkim metama tehnikama STD i WaterLOGSY NMR." Master's thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:884767

Delaš, K. (2024). 'Interakcije 4"-benzil-makrozona i njegova kompleksa s niklom(II) s biološkim metama tehnikama STD i WaterLOGSY NMR', Master's thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:884767

Delaš K. Interakcije 4"-benzil-makrozona i njegova kompleksa s niklom(II) s biološkim metama tehnikama STD i WaterLOGSY NMR [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2024 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:884767

K. Delaš, "Interakcije 4"-benzil-makrozona i njegova kompleksa s niklom(II) s biološkim metama tehnikama STD i WaterLOGSY NMR", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:217:884767

Metadata
TitleInterakcije 4"-benzil-makrozona i njegova kompleksa s niklom(II) s biološkim metama tehnikama STD i WaterLOGSY NMR
Title (english)Interactions of benzyl-4"-macrozone and its nickel(II) complex with biological targets by STD and WaterLOGSY NMR techniques
AuthorKristina Delaš
MentorPredrag Novak (mentor)
Committee memberPredrag Novak (predsjednik povjerenstva)
Committee memberIvana Biljan (član povjerenstva)
Committee memberMirta Rubčić (član povjerenstva)
Committee memberTomislav Jednačak (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2024-02-21, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Povećana rezistencija patogenih bakterija na dosad poznate lijekove i nedostatak razvoja novih antibiotika predstavljaju globalni medicinski problem koji se može riješiti jedino otkrivanjem biološki aktivnih spojeva s izraženim antibakterijskim djelovanjem. Makrolidni antibiotici (makrolidi) imaju široki spektar djelovanja i učinkoviti su na većinu Gram-pozitivnih i Gram-negativnih bakterija. Jedan od najvažnijih predstavnika druge generacije makrolida je azitromicin. Povezivanjem azitromicina i nekih biološki aktivnih tiosemikarbazona dobiveni su njihovi konjugati makrozoni koji su pokazali povećanu učinkovitost i aktivnost na neke višestruko rezistentne sojeve bakterija. Biološka svojstva makrozona mogu se dodatno poboljšati kompleksiranjem s kationima prijelaznih metala. U ovom diplomskom radu istražena je aktivnost benzil-4''-makrozona i kompleksa nikla(II) s makrozonskim 4''- derivatom azitromicina. Interakcije pripravljenih spojeva s ribosomom izoliranim iz bakterije Escherichia coli i s goveđim albuminom iz seruma (BSA) određene su i analizirane pomoću tehnika STD i WaterLOGSY NMR te su određeni epitopi vezanja.
Abstract (english)
An increased resistance of pathogenic bacteria to previously known drugs and the lack of development of new antibiotics represent a global medical problem that can only be solved by discovering biologically active compounds with increased antibacterial activity. Macrolide antibiotics (macrolides) have a broad spectrum of activity and are effective against most Gram-positive and Gram-negative bacteria. One of the most important representatives of the second generation of macrolides is azithromycin. By linking azithromycin and some biologically active thiosemicarbazones, their conjugates, macrozones, were obtained, which showed increased efficiency and activity against some multi-resistant strains of bacteria. The biological properties of macrozones can be further improved by complexing with transition metal cations. In this thesis, the activity of benzyl-4''-macrozone and nickel(II) complex with macrozone 4''-derivative of azithromycin was investigated. The interactions of the prepared compounds with the ribosome isolated from the bacterium Escherichia coli and with bovine albumin (BSA) have been investigated and analysed by using STD and WaterLOGSY NMR techniques and binding epitopes have been determined.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:884767
ProjectNumber: IP-2018-01-8098
Title: Makrozoni, novi konjugati makrolidnih antibiotika: Dizajn, priprava i interakcije
Title: Macrozones, New Conjugates of Macrolide Antibiotics: Design, Synthesis and Interactions
Acronym: Makrozoni/Macrozones
Leader: Predrag Novak
Jurisdiction: Croatia
Funder: HRZZ
Funding stream: IP
Study programmeTitle: Graduate university studies in chemistry; specializations in: Graduate university studies in chemistry
Course: Graduate university studies in chemistry
Study programme type: university
Study level: graduate
Academic / professional title: sveučilišni/a magistar/magistra kemije (sveučilišni/a magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-11 09:49:04