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doctoral thesis
Analiza multielementnog profila, aminokiselina i vazopresina nakon pokušaja samoubojstva osoba s velikim depresivnim poremećajem
Zagreb: University of Zagreb, Faculty of Science, 2016. urn:nbn:hr:217:997242
Drmić, Stipe
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Drmić, S. (2016). Analiza multielementnog profila, aminokiselina i vazopresina nakon pokušaja samoubojstva osoba s velikim depresivnim poremećajem (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:997242

Drmić, Stipe. "Analiza multielementnog profila, aminokiselina i vazopresina nakon pokušaja samoubojstva osoba s velikim depresivnim poremećajem." Doctoral thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:997242

Drmić, Stipe. "Analiza multielementnog profila, aminokiselina i vazopresina nakon pokušaja samoubojstva osoba s velikim depresivnim poremećajem." Doctoral thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:997242

Drmić, S. (2016). 'Analiza multielementnog profila, aminokiselina i vazopresina nakon pokušaja samoubojstva osoba s velikim depresivnim poremećajem', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 20 April 2024, https://urn.nsk.hr/urn:nbn:hr:217:997242

Drmić S. Analiza multielementnog profila, aminokiselina i vazopresina nakon pokušaja samoubojstva osoba s velikim depresivnim poremećajem [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2016 [cited 2024 April 20] Available at: https://urn.nsk.hr/urn:nbn:hr:217:997242

S. Drmić, "Analiza multielementnog profila, aminokiselina i vazopresina nakon pokušaja samoubojstva osoba s velikim depresivnim poremećajem", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:217:997242

Metadata
TitleAnaliza multielementnog profila, aminokiselina i vazopresina nakon pokušaja samoubojstva osoba s velikim depresivnim poremećajem
Title (english)Analysis of multielement profile, aminoacids and vasopressin in suicide attempters with major depression disorder
AuthorStipe Drmić
MentorNinoslav Mimica (mentor)
MBZ: 174626
Committee memberDubravka Hranilović (predsjednik povjerenstva)
Committee memberDolores Britvić (član povjerenstva)
MBZ: 181376
Committee memberJasna Jurasović (član povjerenstva)
MBZ: 160496
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2016, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
Stopa depresivnih poremećaja u pandemijskom je porastu. Većinu samoubojstava i pokušaja samoubojstva počine depresivne osobe. Zbog navedenog, neophodni su pouzdani biomarkeri individualizirane procjene rizika suicidalnog ponašanja. Mjerenje koncentracije elemenata u pojedinim biološkim uzorcima omogućuje uvid u promjenu stanja dinamike metabolizma normalnih i patoloških procesa. Metabolički status bioelemenata (BE) te razina hormona i aminokiselina koje sudjeluju u regulaciji metabolizma mogu biti potencijalni biomarkeri suicidalnog ponašanja. Glavni cilj istraživanja bio je ispitati povezanost i međuodnos elektrolita i elemenata u tragovima, aminokiselina i vazopresina u plazmi ispitanika oboljelih od depresije koji su pokušali samoubojstvo (n=38) u odnosu na kontrolnu skupinu (n=47). Istraživanjem nije potvrđena povezanost koncentracije natrija sa suicidalnošću, a rizik za suicid raste sa sniženom ili prosječnom koncentracijom joda (I), litija (Li), povišenom ili prosječnom koncentracijom barija (Ba) kao i s dobi iznad 43,5 godina. Utvrđena je statistički značajno niža koncentracija asparagina kod suicidalne skupine. Potvrđena je obrnuto proporcionalna povezanost vazopresina i suicidalnosti (p<0,001). Dobiveni rezultati mogli bi biti temelj za pronalazak neurospecifičnih biomarkera za depresiju u sklopu personalizirane medicine.
Abstract (english)
Most of the suicides and suicide attempts are result of depressive disorders. Due to a pandemic increase of such disorders, most suicides and suicide attempts are committed by depressive persons, reliable biomarkers of the suicide risk are needed. Measurement of elements concentration in specific biological samples gives us an insight into metabolic dynamic change in normal and pathological processes. Metabolic status of bioelements as well as hormones and amino acids levels could be the biomarkers of suicidal behavior.The aim of research was to analyze concentracions of electrolytes and trace elements, plasma amino acids and vasopressin in depressed hospitalized suicide attempters (n=38) and to correlate the results with those in control subjects (n=47). The main hypothesis of this research was that there is a significant difference in above mentioned parameters between suicide attempters with major depression disorder and healthy control subjects. Significantly higher concentration of sodium (Na) has not been observed in suicide attempter group. Suicide risk increases with decreased or average concentration of iodine (I) and lithium (Li), increased or average concentration of barium (Ba) as well as the age > 43.5 years. We determined significantly decreased concentration of asparagine in suicide attempters. Negative correlation between arginine vasopressin and suicidal behaviour was found (p<0,001). This study could be the basis for potential development of neuro-specific biomarkers in personalized medicine.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:997242
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-05-12 10:12:42