prikaz prve stranice dokumenta GLIKOZILACIJA IMUNOGLOBULINA G U DOWNOVU SINDROMU
Embargo period 2026-03-04
doctoral thesis
GLIKOZILACIJA IMUNOGLOBULINA G U DOWNOVU SINDROMU
Zagreb: University of Zagreb, Faculty of Science, 2024. urn:nbn:hr:217:657334
Cindrić, Ana
University of Zagreb
Faculty of Science

Institutional repository: Repository of the Faculty of Science

Cite this document

Cindrić, A. (2024). GLIKOZILACIJA IMUNOGLOBULINA G U DOWNOVU SINDROMU (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:657334

Cindrić, Ana. "GLIKOZILACIJA IMUNOGLOBULINA G U DOWNOVU SINDROMU." Doctoral thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:657334

Cindrić, Ana. "GLIKOZILACIJA IMUNOGLOBULINA G U DOWNOVU SINDROMU." Doctoral thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:657334

Cindrić, A. (2024). 'GLIKOZILACIJA IMUNOGLOBULINA G U DOWNOVU SINDROMU', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 06 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:657334

Cindrić A. GLIKOZILACIJA IMUNOGLOBULINA G U DOWNOVU SINDROMU [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2024 [cited 2024 May 06] Available at: https://urn.nsk.hr/urn:nbn:hr:217:657334

A. Cindrić, "GLIKOZILACIJA IMUNOGLOBULINA G U DOWNOVU SINDROMU", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:217:657334

Metadata
TitleGLIKOZILACIJA IMUNOGLOBULINA G U DOWNOVU SINDROMU
Title (english)IMMUNOGLOBULIN G GLYCOSYLATION IN DOWN SYNDROME
AuthorAna Cindrić
MentorGordan Lauc (mentor)
MentorJasminka Krištić (komentor)
Committee memberOlga Gornik Kljaić (predsjednik povjerenstva)
Committee memberPetra Korać (član povjerenstva)
Committee memberIrena Trbojević Akmačić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
Zagreb
Defense date and country2024-03-04, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
Glikozilacija je jedna od najčešćih ko- i posttranslacijskih modifikacija proteina. Glikani vezani na imunoglobulin G (IgG) utječu na njegovu strukturu i funkciju i mijenjaju se s dobi te u brojnim fiziološkim i patološkim stanjima organizma. Znakovi preuranjenog starenja, kao i brojne druge bolesti, česti su kod Downova sindroma (DS). Tekućinskom kromatografijom ultravisoke učinkovitosti analizirana je glikozilacija IgG-a u tri populacije osoba s DS-om za koje su postojali klinički podaci o najčešćim komorbiditetima i uspoređena s onom njihovih zdravih vršnjaka. Proučen je utjecaj produkata gena kromosoma 21 B3GALT5, RUNX1 i DYRK1A na glikozilaciju IgG-a u DS-u digestijom glikana IgG-a egzoglikozidazama te kemijskom inhibicijom produkata gena u limfoblastoidnim staničnim linijama. Pokazano je kako glikozilacija IgG-a osoba s DS-om neovisno o učestalim komorbiditetima odgovara kronološki starijim zdravim osobama. U korištenim eksperimentalnim sustavima RUNX1 ima izravan utjecaj na glikozilaciju IgG-a u DS-u, dok B3GALT5 i DYRK1A nemaju.
Abstract (english)
Glycosylation is one of the most common co- and posttranslational modifications. Glycans attached to immunoglobulin G (IgG) affect its function and change with age and in numerous physiological and pathological conditions. Signs of premature aging, along with many other diseases, are common in Down syndrome (DS). IgG glycosylation of three DS populations that had clinical data on the most common comorbidities was analyzed by ultra-high performance liquid chromatography and compared to their healthy peers. The impact of chromosome 21 gene products B3GALT5, DYRK1A and RUNX1 on IgG glycosylation was studied using enzymatic digestions of IgG glycans and IgG-producing lymphoblastoid cell lines obtained from individuals with and without DS. IgG glycosylation was revealed to be significantly shifted in the direction of aging in DS, showing a ubiquitous trend independent of comorbidities, and an insight into the effect of gene products B3GALT5, DYRK1A and RUNX1 on IgG glycosylation was provided.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:657334
Promotion2024
ProjectNumber: PZS-2019-02-4277
Title: Glikozilacija proteina u bolestima povezanim sa starenjem kroz istraživanje preuranjenog starenja u Downovom sindromu
Acronym: GlycoDown
Leader: Gordan Lauc
Jurisdiction: Croatia
Funder: Europska unija (iz Europskog socijalnog fonda u sklopu Operativnog programa Učinkoviti ljudski potencijali 2014.-2020.)
Funding stream: Program „Znanstvena suradnja“ Hrvatske zaklade za znanost
Study programmeTitle: Doctoral study
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti u području prirodnih znanosti (doktor/doktorica znanosti u području prirodnih znanosti)
Type of resourceText
File originBorn digital
Access conditionsEmbargoed access
Embargo expiration date: 2026-03-04
Terms of useLicence In copyright icon
Created on2024-04-02 10:19:36