According to the Croatian Earthquake Catalog, during the five-year period from 2016 to 2020, a total of 19721 earthquakes occured in Croatia and its immediate surrounding areas, with 20 main events with local magnitude ML ≥ 4.0. The most seismically active region was southern Croatia, where over 11000 events were located, including 17 events with magnitude ML ≥ 4.0. The second most active region was central and northern Croatia, where two of the strongest events in Croatia happened during the observed period. The strongest event, with moment magnitude MW = 6.4 (ML = 6.2), occurred near the town of Petrinja on December 29, 2020. The second strongest event, with magnitude ML = 5.3, happened nine months earlier in the vicinity of Zagreb on March 22, 2020. In addition to spatial earthquake analysis, a temporal analysis of earthquakes was performed, including a comparison of the occurrence of main events in Croatia with a Poisson process used to describe rare events. The magnitude of completeness for the declustered Croatian earthquake catalog, determined using the MAXC and MBS methods for the period between 2016 and 2020, in the Croatia and its immediate vicinity, is Mc = 1.2. The associated coefficient b (slope of the curve) of the Gutenberg-Richter law is found to be 0.91. Furthermore, a detailed analysis of seismicity was conducted for regions of Croatia (eastern Croatia, northern and central Croatia, western Croatia and southern Croatia), determining the magnitude of completeness for each region's catalog and calculating the corresponding Gutenberg-Richter coefficients.