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master's thesis
Priprava i karakterizacija 9a-makrozona izvedenih iz 4-aminobenzojeve kiseline i derivata salicilaldehida
Zagreb: University of Zagreb, Faculty of Science, 2024. urn:nbn:hr:217:524412
Divjak, Leda
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Divjak, L. (2024). Priprava i karakterizacija 9a-makrozona izvedenih iz 4-aminobenzojeve kiseline i derivata salicilaldehida (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:524412

Divjak, Leda. "Priprava i karakterizacija 9a-makrozona izvedenih iz 4-aminobenzojeve kiseline i derivata salicilaldehida." Master's thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:524412

Divjak, Leda. "Priprava i karakterizacija 9a-makrozona izvedenih iz 4-aminobenzojeve kiseline i derivata salicilaldehida." Master's thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:524412

Divjak, L. (2024). 'Priprava i karakterizacija 9a-makrozona izvedenih iz 4-aminobenzojeve kiseline i derivata salicilaldehida', Master's thesis, University of Zagreb, Faculty of Science, accessed 14 July 2024, https://urn.nsk.hr/urn:nbn:hr:217:524412

Divjak L. Priprava i karakterizacija 9a-makrozona izvedenih iz 4-aminobenzojeve kiseline i derivata salicilaldehida [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2024 [cited 2024 July 14] Available at: https://urn.nsk.hr/urn:nbn:hr:217:524412

L. Divjak, "Priprava i karakterizacija 9a-makrozona izvedenih iz 4-aminobenzojeve kiseline i derivata salicilaldehida", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:217:524412

Metadata
TitlePriprava i karakterizacija 9a-makrozona izvedenih iz 4-aminobenzojeve kiseline i derivata salicilaldehida
Title (english)Synthesis and characterization of a 9a-macrozone derived from 4-aminobenzoic acid and salicylaldehyde derivatives
AuthorLeda Divjak
MentorPredrag Novak (mentor)
MentorKristina Smokrović (komentor)
Committee memberPredrag Novak (predsjednik povjerenstva)
Committee memberĐani Škalamera (član povjerenstva)
Committee memberJana Pisk (član povjerenstva)
Committee memberTomislav Jednačak (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2024-07-08, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Prekomjerna uporaba antibiotika dovela je do naglog razvijanja rezistencije na antibiotike te je potreban razvoj novih. Jedan od najčešće korištenih antibiotika je azitromicin, antibiotik koji pripada skupini makrolidnih antibiotika. Makrozoni su spojevi koji nastaju reakcijom makrolida, tj. azitromicina i tiosemikarbazona. Tiosemikarbazoni mogu djelovati antibakterijski i antiupalno, a njihovi kompleksi s prijelaznim metalima poput bakra ili nikla dodatno povećavaju biološku aktivnost. U ovom radu pripravljeni su tiosemikarbazoni iz 4-aminobenzojeve kiseline i derivata salicilaldehida. Zatim su pripremljeni odgovarajući makrozoni reakcijom 9a-aminopropilnog derivata azitromicina i prethodno pripravljenih tiosemikarbazona. Pripravljeni su kompleksi makrozona s niklom(II) i bakrom(II). Spojevi sintetizirani u svakom koraku karakterizirani su spektroskopijom NMR te je ispitana njihova biološka aktivnost.
Abstract (english)
Excessive use of antibiotics has led to bacterial resistance to antibiotics, and the development of new ones is urgently needed. One of the most commonly used antibiotics is azithromycin, an antibiotic that belongs to the group of macrolide class. Macrozones are compounds formed by the reaction of macrolides, i.e. azithromycin and thiosemicarbazones. Thiosemicarbazones can have antibacterial and anti-inflammatory effects and their complexes with transition metals such as copper or nickel further increase biological activity. In this thesis, thiosemicarbazones were prepared from 4-aminobenzoic acid and salicylaldehyde derivatives. Subsequently, the corresponding macrozones were prepared by the reaction of the 9a-aminopropyl derivative of azithromycin and previously prepared thiosemicarbazones. Finally, macrozone complexes with nickel(II) and copper(II) were prepared. The compounds synthesized in each step were characterized by NMR spectroscopy and their biological acivities were evaluated.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:524412
ProjectNumber: IP-2018-01-8098
Title: Makrozoni, novi konjugati makrolidnih antibiotika: Dizajn, priprava i interakcije
Title: Macrozones, New Conjugates of Macrolide Antibiotics: Design, Synthesis and Interactions
Acronym: Makrozoni/Macrozones
Leader: Predrag Novak
Jurisdiction: Croatia
Funder: Hrvatska zaklada za znanost
Funding stream: Research Projects
Study programmeTitle: Graduate university studies in chemistry; specializations in: Graduate university studies in chemistry
Course: Graduate university studies in chemistry
Study programme type: university
Study level: graduate
Academic / professional title: sveučilišni/a magistar/magistra kemije (sveučilišni/a magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-07-10 12:10:14