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master's thesis
Razvoj metode za pripravu kiralnih višesupstituiranih ciklopentadienilnih liganada
Zagreb: University of Zagreb, Faculty of Science, 2024. urn:nbn:hr:217:200844
Purić, Marko
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Purić, M. (2024). Razvoj metode za pripravu kiralnih višesupstituiranih ciklopentadienilnih liganada (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:200844

Purić, Marko. "Razvoj metode za pripravu kiralnih višesupstituiranih ciklopentadienilnih liganada." Master's thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:200844

Purić, Marko. "Razvoj metode za pripravu kiralnih višesupstituiranih ciklopentadienilnih liganada." Master's thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:200844

Purić, M. (2024). 'Razvoj metode za pripravu kiralnih višesupstituiranih ciklopentadienilnih liganada', Master's thesis, University of Zagreb, Faculty of Science, accessed 26 August 2024, https://urn.nsk.hr/urn:nbn:hr:217:200844

Purić M. Razvoj metode za pripravu kiralnih višesupstituiranih ciklopentadienilnih liganada [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2024 [cited 2024 August 26] Available at: https://urn.nsk.hr/urn:nbn:hr:217:200844

M. Purić, "Razvoj metode za pripravu kiralnih višesupstituiranih ciklopentadienilnih liganada", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:217:200844

Metadata
TitleRazvoj metode za pripravu kiralnih višesupstituiranih ciklopentadienilnih liganada
Title (english)Development of method for synthesis of chiral multisubstituted cyclopentadienyl ligands
AuthorMarko Purić
MentorNikola Topolovčan (mentor)
Committee memberĐani Škalamera (predsjednik povjerenstva)
Committee memberBiserka Prugovečki (član povjerenstva)
Committee memberAleksandra Maršavelski (član povjerenstva)
Committee memberŽeljka Car (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2024-07-11, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Kompleksi prijelaznih metala s kiralnim 1,2-supstituiranim ciklopentadienilnim ligandima do sada su uspješno korišteni u brojnim stereoselektivnim transformacijama. Novija istraživanja upućuju da dodatna supstitucija prstena ciklopentadiena može povoljno utjecati na modulaciju stereoelektronskih svojstava katalitičkih džepova kompleksa. Međusobna ovisnost supstitucijskog uzorka i stereoelektronskih svojstava ukazuje na potrebu za novijim i učinkovitijim metodama sinteze takvih liganada. Ovaj rad predstavlja metodologiju za njihovu pripravu s osnovnom hipotezom da se kiralni višesupstituirani ciklopentadienilni ligandi mogu pripraviti reakcijom neterminalnog diina s Negishijevim reagensom pri čemu nastaju odgovarajući cirkonabiciklički međuprodukti. Sintetski put započinje sintezom diina i završava ciklizacijom diina s Negishijevim reagensom nakon čega slijedi reakcija unakrsnog povezivanja s alkil-dijodidom. Konačni produkt je kiralni višesupstituirani ciklopentadienilni ligand s "proširenom bočnom stijenkom" i dodanom "prednjom stijenkom".
Abstract (english)
Transition metal complexes with chiral 1,2-substituted cyclopentadienyl ligands have so far been successfully used in numerous stereoselective transformations. Recent research indicates that additional substitution of the cyclopentadiene ring can favorably influence the modulation of the stereoelectronic properties of the catalytic pockets of such complexes. The interdependence of the substitution pattern and stereoelectronic properties indicates the need for newer and more efficient methods for their synthesis. This work presents methodology for their preparation with the basic hypothesis that chiral multisubstituted cyclopentadienyl ligands can be prepared by the reaction of a non-terminal diyne with the Negishi reagent, resulting in the formation of corresponding zirconabicyclic intermediates. The synthetic route begins with the synthesis of diynes and concludes with the cyclization of diynes with the Negishi reagent, followed by a cross-coupling reaction with an alkyl diiodide. The final product is a chiral multisubstituted cyclopentadienyl ligand with an "extended sidewall" and an added "frontwall".
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:200844
Study programmeTitle: Graduate university studies in chemistry; specializations in: Graduate university studies in chemistry
Course: Graduate university studies in chemistry
Study programme type: university
Study level: graduate
Academic / professional title: sveučilišni/a magistar/magistra kemije (sveučilišni/a magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-07-12 11:51:37