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doctoral thesis
Mutacije u genu za nukleokapsidni protein virusa hepatitisa C u oboljelih od kroničnoga hepatitisa
Zagreb: University of Zagreb, Faculty of Science, 2016. urn:nbn:hr:217:192434
Mohar Vitezić, Bojana
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Mohar Vitezić, B. (2016). Mutacije u genu za nukleokapsidni protein virusa hepatitisa C u oboljelih od kroničnoga hepatitisa (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:192434

Mohar Vitezić, Bojana. "Mutacije u genu za nukleokapsidni protein virusa hepatitisa C u oboljelih od kroničnoga hepatitisa." Doctoral thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:192434

Mohar Vitezić, Bojana. "Mutacije u genu za nukleokapsidni protein virusa hepatitisa C u oboljelih od kroničnoga hepatitisa." Doctoral thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:192434

Mohar Vitezić, B. (2016). 'Mutacije u genu za nukleokapsidni protein virusa hepatitisa C u oboljelih od kroničnoga hepatitisa', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 29 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:192434

Mohar Vitezić B. Mutacije u genu za nukleokapsidni protein virusa hepatitisa C u oboljelih od kroničnoga hepatitisa [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2016 [cited 2024 December 29] Available at: https://urn.nsk.hr/urn:nbn:hr:217:192434

B. Mohar Vitezić, "Mutacije u genu za nukleokapsidni protein virusa hepatitisa C u oboljelih od kroničnoga hepatitisa", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:217:192434

Metadata
TitleMutacije u genu za nukleokapsidni protein virusa hepatitisa C u oboljelih od kroničnoga hepatitisa
Title (english)Mutations in core region of hepatitis C virus in patients with chronic hepatitis
AuthorBojana Mohar Vitezić
MentorBlaženka Grahovac (mentor)
MBZ: 112820
Committee memberSnježana Židovec-Lepej (član povjerenstva)
MBZ: 228211
Committee memberSilvija Černi (član povjerenstva)
Committee memberSandra Milić (član povjerenstva)
MBZ: 243151
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2016, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		576 - Cellular and subcellular biology. Cytology
Abstract
Virus hepatitisa C (HCV) je globalno prisutan patogen koji u zaraženih osoba može uzrokovati različite kliničke slike. Genetika HCV-a i infekcija su kompleksni i specifični procesi, zbog međusobnog odnosa domaćina i virusa, te uzrokuju različiti klinički tijek bolesti jetre. Nukleokapsidni protein je kompleksan HCV protein koji može u određenoj mjeri modificirati ulazak HCV virusa u stanicu, replikacijski ciklus te formiranje i oslobađanje HCV-a iz stanice. Nukleokapsidni protein sudjeluje pri vezivanju s mnogim staničnim proteinima i usmjerava određene stanične signalne puteve, te u konačnici može pridonijeti razvoju hepatokarcinogeneze. Cilj rada bio je istražiti postoje li korelacije između mutacija u nukleokapsidnoj regiji, te virusnih i patohistoloških parametara u kroničnoj infekciji HCV-om, u uzorcima seruma i jetre 87 ispitanika, te utvrditi postoji li povezanost prisutnih mutacija s progresivnijim tijekom jetrene bolesti. Rezultati rada pokazuju značajnu pozitivnu korelaciju podtipa 1b i koncentracije virusne RNA u krvi s prisutnošću mutacija R70Q, T75A i M91L/C nukleokapsidnog gena. Patohistološki parametri (stupanj aktivnosti hepatitisa i stadij fibroze) udruženi su s prisutnošću mutacija R70Q i M91L/C. Rezultati istraživanja pokazuju da učestalost mutacija i određeni tip mutacija pozitivno koreliraju s progresivnijim i težim tijekom jetrene bolesti.
Abstract (english)
Hepatitis C virus (HCV) is a globally prevalent pathogen with diverse clinical outcomes. Considering the interlinking relation of the host and the virus, the genetics of HCV and infection in humans is specific and individual . Thus, it can result in a variety of different disease course among the infected hepatitis C patients. HCV core is complex protein, capable of modifying hepatitis C life cycle by participating in interactions with host proteins, altering cellular signaling pathways and contributing in hepatocarcinogenesis. The aim of this study was to investigate correlations between the changes of core region and the viral and patohistological parameters of chronic hepatitis C in liver and serum samples of 87 patients. The aim was also to determine coherence of core region mutations and liver disease progression. Results of this study indicate significant correlation of genotype 1b and basal viremia with presence of R70Q, T75A i M91L/C mutations. Patohistological parameters (hepatitis activity grade and fibrosis stage) were associated with presence of R70Q and M91L/C mutations. Finally, results of our study indicate that frequency and the type of mutations positively correlates with liver disease progressivity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:192434
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-05-16 09:43:09