prikaz prve stranice dokumenta Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV)
No public access
doctoral thesis
Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV)
Zagreb: University of Zagreb, Faculty of Science, 2016. urn:nbn:hr:217:746737
Vojvoda Parčina, Valerija
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Vojvoda Parčina, V. (2016). Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV) (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:746737

Vojvoda Parčina, Valerija. "Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV)." Doctoral thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:746737

Vojvoda Parčina, Valerija. "Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV)." Doctoral thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:746737

Vojvoda Parčina, V. (2016). 'Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV)', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:746737

Vojvoda Parčina V. Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV) [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2016 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:746737

V. Vojvoda Parčina, "Kemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV)", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:217:746737

Metadata
TitleKemokini i kemokinski receptori povezani s imunološkim Th1 i Th2 odgovorom na infekciju respiratornim sincicijskim virusom (RSV)
Title (english)Th1 and Th2 associated chemokines and chemokine receptors in RSV infection
AuthorValerija Vojvoda Parčina
MentorKrešo Bendelja (mentor)
Committee memberNada Oršolić (član povjerenstva)
Committee memberMirjana Turkalj (član povjerenstva)
Committee memberSnježana Židovec-Lepej (član povjerenstva)
MBZ: 228211
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2016, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
RSV (engl. respiratory syncytial virus) je najčešći uzročnik respiratornih infekcija djece do druge godine. Razvoj težih oblika bolesti i česte reinfekcije mogu se povezati s istovremenim razvojem antivirusne Th1 i nepoželjne Th2 imunoreakcije. Th1 imunoreakcija je povezana s povišenom proizvodnjom IFN-γ te kemokina CXCL10 i CXCL9, dok je Th2 povezana s proizvodnjom IL-4 odnosno CCL17 i CCL22. U djece s akutnom RSV-infekcijom smo lokalno i sistemski odredili kemokinski profil obzirom na tip-1 i tip-2 imunoreakcije te ekspresiju specifičnih kemokinskih receptora (CXCR3 i CCR4) na T-limfocitima. Radi boljeg uvida u usmjeravanje diferencijacije T-limfocita u tip-2, određena je ekspresija CRTh2-receptora. Rezultati su pokazali da RSV specifično podiže razinu CXCL10 i CCL17 tijekom akutne infekcije. Neodgovarajući razvoj memorijske imunosti popraćen je povećanim postotkom TEM-limfocita tipa-1 i tipa-2, te izostankom razvoja dugoživućih memorijskih T-limfocita tipa-1. Nemogućnost razvoja odgovarajuće memorijske imunosti u kombinaciji s istovremenim razvojem oba tipa imunosnog odgovora, mogao bi igrati veliku ulogu u patogenezi RSV-a.
Abstract (english)
RSV (respiratory syncytial virus) is the most common cause of respiratory infections in infants. Development of severe lower respiratory tract infections and frequent reinfections could relate with the simultaneous development of protective Th1 and pathogenic Th2 immune responses. Th1 is represented by predominant IFN-γ and associated with increased CXCL10 and CXCL9 production. Contrary, Th2 is represented by increased IL-4 and CCL17/CCL22 production. We have determined the chemokine profile of children with severe RSV infection, in addition to specific chemokine receptors CXCR3 and CCR4 expression on memory T cells. To confirm type-2 T-cell polarization, we also analyzed CRTh2 receptor expression. Results showed RSV specifically increases CXCL10 and CCL17 levels in acute infection, followed by inadequate immune memory development in terms of higher percentages of type-1 and type-2 TEM cells, and lower percentages of long-living type-1 memory T cells. Failure in the development of appropriate immune memory, together with the presence of both type-1 and type-2 immune response, could play an important role in RSV pathogenesis and reinfections.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:746737
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2017-05-16 11:29:30