prikaz prve stranice dokumenta Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke
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doctoral thesis
Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke
Zagreb: University of Zagreb, Faculty of Science, 2015. urn:nbn:hr:217:683477
Alvir, Ilija
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Alvir, I. (2015). Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:683477

Alvir, Ilija. "Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke." Doctoral thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:683477

Alvir, Ilija. "Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke." Doctoral thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:683477

Alvir, I. (2015). 'Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 26 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:683477

Alvir I. Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2015 [cited 2024 December 26] Available at: https://urn.nsk.hr/urn:nbn:hr:217:683477

I. Alvir, "Uloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:217:683477

Metadata
TitleUloga hipoksije u razvoju trostruko negativnoga duktalnoga invazivnoga karcinoma dojke
Title (english)Role of hypoxia in the development of triple negative invasive ductal breast carcinoma
AuthorIlija Alvir
MentorLidija Beketić-Orešković (mentor)
MBZ: 143056
Committee memberNada Oršolić (član povjerenstva)
Committee memberSonja Levanat (član povjerenstva)
Committee memberBožena Šarčević (član povjerenstva)
MBZ: 87995
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2015, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		57 - Biological sciences. Physical anthropology. Biodiversity
Abstract
Karcinom dojke najzastupljeniji je tip karcinoma u žena. Brojni tumorski pokazatelji koriste se za praćenje karcinoma dojke: veličina, multicentričnost, histološki tip i gradus, status estrogenskih i progesteronskih receptora (ER i PR), HER2 status, limfovaskularna invazija, pozitivni limfni čvorovi aksile i prisutne udaljene metastaze. Trostruko negativan karcinom dojke (eng. triple negative breast cancer, TNBC) najagresivniji je podtip karcinoma dojke s visokom stopom recidiva i lošijim preživljenjem bolesnica. Tumorska hipoksija važan je pokazatelj prognoze maligne bolesti povezana s agresivnijim rastom, ranijim metastaziranjem i lošim odgovorom tumora na liječenje. U hipoksičnim uvjetima dolazi do pojačane izraženosti p53 i indukcije apoptoze preko Bcl-2. Imunohistokemijskom metodom istraživana je povezanost biljega stanične hipoksije karboanhidraze IX (CAIX), Bcl-2, p53 i Ki-67 s pokazateljima agresivnosti karcinoma. Rezultati pokazuju da je istraživani biljeg hipoksije CAIX u statistički značajnoj pozitivnoj korelaciji s p53 te s biljegom proliferacije Ki-67. Protein p53 u pozitivnoj je korelaciji s veličinom tumora te granično s gradusom. Biljeg apoptoze Bcl-2 nije u korelaciji s ostalim ispitivanim biljezima kao ni s pokazateljima agresivnosti karcinoma. Istraživanje je potvrdilo da TNBC imaju agresivnije ponašanje od samog početka. S obzirom da velika većina TNBC ima izražene biljege hipoksije, neki od tih biljega mogli bi biti dio ciljane terapije.
Abstract (english)
Breast cancer (BC) is the most common type of cancer in women. Numerous tumor indicators are used to monitor BC: size, multicentricity, histological type and grade, status of estrogen and progesterone receptors (ER and PR), HER2 status, lymphovascular invasion, positive axillary lymph nodes and presence of distant metastases. The triple negative breast cancer (triple negative breast cancer, TNBC) is very aggressive subtype of BC with a high rate of recurrence and poor survival. Tumor hypoxia is an important indicator of malignant disease prognosis, associated with aggressive growth, early metastasis and poor response to treatment. In hypoxic conditions an increased expression of p53 occurs along with induction of apoptosis via Bcl-2. Using immunohistochemical methods, we investigated the correlation of expression of cellular hypoxia markers, carbonic anhydrase IX (CAIX), Bcl-2, p53 and Ki-67 with indicators of cancer aggressiveness. The results indicated that investigated hypoxia marker CAIX is in statistically significant positive correlation with both p53 and Ki-67. Only p53 was correlated with any of investigated marker. Apoptotic marker Bcl-2 is more expressed at larger tumors. This study confirmed that TNBC have aggressive behavior from the very beginning. Since the vast majority of TNBC expressed markers of hypoxia maybe some of these markers have potential for development targeted therapies.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:683477
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
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Created on2017-05-16 11:46:38