prikaz prve stranice dokumenta Uloga limfocita CD4+FOXP3+ I CD4+TH17+ u graničnom akutnom celularnom odbacivanju bubrežnih transplantata
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doctoral thesis
Uloga limfocita CD4+FOXP3+ I CD4+TH17+ u graničnom akutnom celularnom odbacivanju bubrežnih transplantata
Zagreb: University of Zagreb, Faculty of Science, 2015. urn:nbn:hr:217:128710
Bacalja, Jasna
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Bacalja, J. (2015). Uloga limfocita CD4+FOXP3+ I CD4+TH17+ u graničnom akutnom celularnom odbacivanju bubrežnih transplantata (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:128710

Bacalja, Jasna. "Uloga limfocita CD4+FOXP3+ I CD4+TH17+ u graničnom akutnom celularnom odbacivanju bubrežnih transplantata." Doctoral thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:128710

Bacalja, Jasna. "Uloga limfocita CD4+FOXP3+ I CD4+TH17+ u graničnom akutnom celularnom odbacivanju bubrežnih transplantata." Doctoral thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:128710

Bacalja, J. (2015). 'Uloga limfocita CD4+FOXP3+ I CD4+TH17+ u graničnom akutnom celularnom odbacivanju bubrežnih transplantata', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 01 January 2025, https://urn.nsk.hr/urn:nbn:hr:217:128710

Bacalja J. Uloga limfocita CD4+FOXP3+ I CD4+TH17+ u graničnom akutnom celularnom odbacivanju bubrežnih transplantata [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2015 [cited 2025 January 01] Available at: https://urn.nsk.hr/urn:nbn:hr:217:128710

J. Bacalja, "Uloga limfocita CD4+FOXP3+ I CD4+TH17+ u graničnom akutnom celularnom odbacivanju bubrežnih transplantata", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:217:128710

Metadata
TitleUloga limfocita CD4+FOXP3+ I CD4+TH17+ u graničnom akutnom celularnom odbacivanju bubrežnih transplantata
Title (english)The role of CD4+FOXP3+ I CD4+TH17+ lymphocytes in borderline acute cellular rejection of renal allografts
AuthorJasna Bacalja
MentorDanica Galešić-Ljubanović (mentor)
MBZ: 203674
Committee memberMladen Knotek (član povjerenstva)
MBZ: 202120
Committee memberGordana Lacković-Venturin (član povjerenstva)
Committee memberNada Oršolić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2015, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		576 - Cellular and subcellular biology. Cytology
Abstract
Granično akutno celularno odbacivanje bubrežnog presatka (granično ACO) je karakterizirano histološkim promjenama koje upućuju na akutno celularno odbacivanje, ali ne zadovoljavaju sve kriterije potrebne za postavljanje definitivne dijagnoze akutnog celularnog odbacivanja. Pokušali smo odrediti može li postotak limfocita CD4+Foxp3+ i CD4+Th17+ u upalnom infiltratu bubrežnog presatka s histološkim karakteristikama graničnog ACO pomoći u određivanju radi li se o reakciji akutnog odbacivanja presatka ili fiziološkoj prilagodbi organizma na donirani organ. Uz to smo pokušali utvrditi povezanost limfocita CD4+Foxp3+ i CD4+Th17+ s nastajanjem akutnih i kroničnih promjena u transplantatu bubrega. Zaključeno je da limfociti CD4+Th17+ pojačavaju akutne upalne promjene i vjerojatno sudjeluju u njihovom nastanku dok limfociti CD4+Foxp3+ u bubrežnom presatku s graničnim ACO nisu povezani s histološkim i kliničkim pokazateljima reakcije odbacivanja. Zaključeno je i da prisutnost limfocita CD4+Th17+ u graničnom ACO može poslužiti za definiranje stvarnog ACO u pacijenata s histološkim graničnim ACO tako što veći broj označava reakciju odbacivanja.
Abstract (english)
Borderline acute cellular rejection of renal allograft (borderline ACR) is considered when histological changes in renal allograft tissue are suspicious for rejection, but do not have enough criteria for making a diagnosis of acute cellular rejection. We wanted to define if CD4+Foxp3+ and CD4+Th17+ lymphocytes in renal allograft tissue with borderline ACR can determine if the reaction is indeed acute rejection or is it just physiological conditioning of the body to new organ. Also, we wanted to explore if these lymphocytes are involved in arising of acute and chronic changes in renal allograft. Based on the results we concluded that CD4+Th17+ lymphocytes increase acute changes and probably have a role in their evolving while the number of CD4+Foxp3+ lymphocytes does not correlate with rejection in borderline ACR, but the number of CD4+Th17+ lymphocytes in renal allograft tissue with borderline ACR can determine if the reaction is indeed acute rejection.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:128710
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsClosed access
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Created on2017-05-16 12:13:57