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doctoral thesis
BIOLOGICAL DETERMINANTS OF LONGEVITY IN A CROATIAN OLDEST-OLD POPULATION
Zagreb: University of Zagreb, Faculty of Science, 2024. urn:nbn:hr:217:958116
Šetinc, Maja
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Šetinc, M. (2024). BIOLOGICAL DETERMINANTS OF LONGEVITY IN A CROATIAN OLDEST-OLD POPULATION (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:958116

Šetinc, Maja. "BIOLOGICAL DETERMINANTS OF LONGEVITY IN A CROATIAN OLDEST-OLD POPULATION." Doctoral thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:958116

Šetinc, Maja. "BIOLOGICAL DETERMINANTS OF LONGEVITY IN A CROATIAN OLDEST-OLD POPULATION." Doctoral thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:958116

Šetinc, M. (2024). 'BIOLOGICAL DETERMINANTS OF LONGEVITY IN A CROATIAN OLDEST-OLD POPULATION', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:958116

Šetinc M. BIOLOGICAL DETERMINANTS OF LONGEVITY IN A CROATIAN OLDEST-OLD POPULATION [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2024 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:217:958116

M. Šetinc, "BIOLOGICAL DETERMINANTS OF LONGEVITY IN A CROATIAN OLDEST-OLD POPULATION", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:217:958116

Metadata
TitleBIOLOGICAL DETERMINANTS OF LONGEVITY IN A CROATIAN OLDEST-OLD POPULATION
Title (croatian)BIOLOŠKE ODREDNICE DUGOVJEČNOSTI U HRVATSKOJ POPULACIJI OSOBA DUBOKE STAROSTI
AuthorMaja Šetinc
MentorTatjana Škarić-Jurić (mentor)
Committee memberMarijana Peričić Salihović (predsjednik povjerenstva)
Committee memberTihomir Balog (član povjerenstva)
Committee memberMaja Matulić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2024-07-15, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		57 - Biological sciences. Physical anthropology. Biodiversity
Abstract
Research of long-lived individuals is key for better understanding of the ageing process and the factors that contribute to successful ageing. In this study, 43 genetic variants with previous association to longevity were explored in the population of Croatian oldest-olds (85+ years), along with health-related parameters and relative telomere length, to determine their impact on longevity and late-life survival. Only one variant, associated with MRE11 gene, differed between the study group and the young control group. There was a difference in the variants that contributed to reaching longevity (90 years) and extreme longevity (95 years), with the only variant shared between the two models being TP53 rs1042522. SNP-SNP interactions had a significant effect on survival above the age of 85, with CDKN2B being the most important interaction partner. Finally, health-related parameters contributed to survival in advanced age independently of genetic factors, while relative telomere length did not show any association.
Abstract (croatian)
Istraživanja dugovječnih pojedinaca ključna su za bolje razumijevanje procesa starenja, kao i za stjecanje saznanja o čimbenicima koji doprinose uspješnom starenju. U ovom istraživanju 43 genetske varijante prethodno povezane s dugovječnošću, parametri povezani sa zdravljem i relativna duljina telomera istraživani su na hrvatskom uzorku osoba duboke starosti (85+ godina) kako bi se utvrdio njihov doprinos dugovječnosti i preživljenju u dubokoj starosti. Ispitanici su se od kontrolne skupine mladih osoba razlikovali samo u jednoj varijanti, povezanoj s genom MRE11. Utvrđena je razlika u varijantama koje su doprinosile doživljenju dugovječnosti (90 godina) i ekstremne dugovječnosti (95 godina), s tim da je jedino rs1042522 u genu TP53 bila u oba modela. Interakcije između lokusa imale su značajan učinak na preživljenje iznad 85 godina, pri čemu je najvažniji sudionik bio gen CDKN2B. Zdravstvene varijable također su doprinosile preživljenju u dubokoj starosti neovisno od genetskih faktora, dok relativna duljina telomera nije pokazala povezanost s preživljenjem.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:217:958116
Promotion2024
ProjectNumber: IP-2018-01-2497
Title: Zdravstvene, kulturne i biološke odrednice dugovječnosti: antropološka studija preživljenja u dubokoj starosti
Acronym: HECUBA
Leader: Tatjana Škarić-Jurić
Jurisdiction: Croatia
Funder: Hrvatska zaklada za znanost
Funding stream: Research Projects
Study programmeTitle: Doctoral study
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti u području prirodnih znanosti (doktor/doktorica znanosti u području prirodnih znanosti)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-09-03 10:20:38