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doctoral thesis
IMPACT OF TRAINING FREQUENCY ON BIOLOGICAL AGE GLYCAN BIOMARKERS AND INJURY PREDISPOSITION
Zagreb: University of Zagreb, Faculty of Science, 2024. urn:nbn:hr:217:649248
Šimunić Briški, Nina
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Šimunić Briški, N. (2024). IMPACT OF TRAINING FREQUENCY ON BIOLOGICAL AGE GLYCAN BIOMARKERS AND INJURY PREDISPOSITION (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:649248

Šimunić Briški, Nina. "IMPACT OF TRAINING FREQUENCY ON BIOLOGICAL AGE GLYCAN BIOMARKERS AND INJURY PREDISPOSITION." Doctoral thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:649248

Šimunić Briški, Nina. "IMPACT OF TRAINING FREQUENCY ON BIOLOGICAL AGE GLYCAN BIOMARKERS AND INJURY PREDISPOSITION." Doctoral thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:649248

Šimunić Briški, N. (2024). 'IMPACT OF TRAINING FREQUENCY ON BIOLOGICAL AGE GLYCAN BIOMARKERS AND INJURY PREDISPOSITION', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 18 January 2025, https://urn.nsk.hr/urn:nbn:hr:217:649248

Šimunić Briški N. IMPACT OF TRAINING FREQUENCY ON BIOLOGICAL AGE GLYCAN BIOMARKERS AND INJURY PREDISPOSITION [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2024 [cited 2025 January 18] Available at: https://urn.nsk.hr/urn:nbn:hr:217:649248

N. Šimunić Briški, "IMPACT OF TRAINING FREQUENCY ON BIOLOGICAL AGE GLYCAN BIOMARKERS AND INJURY PREDISPOSITION", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:217:649248

Metadata
TitleIMPACT OF TRAINING FREQUENCY ON BIOLOGICAL AGE GLYCAN BIOMARKERS AND INJURY PREDISPOSITION
Title (croatian)UTJECAJ UČESTALOSTI TRENIRANJA NA GLIKANSKE BIOMARKERE BIOLOŠKE DOBI I PREDISPOZICIJE ZA NASTANAK OZLJEDA
AuthorNina Šimunić Briški
MentorGordan Lauc (mentor)
Committee memberAleksandar Vojta (predsjednik povjerenstva)
Committee memberDubravko Pavoković (član povjerenstva)
Committee memberOlga Gornik Kljaić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2024-06-24, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
Regular moderate exercise has multiple beneficial effects, yet very little is known about the impact of exercise on immunoglobulin G (IgG) glycosylation. In this thesis, the aim was to analyze the impact of various training frequencies on glycan biomarkers of biological age and to investigate currently related gene variants associated with soft-tissue injuries. The results demonstrated that glycan profiles of regularly moderately active population had the lowest GlycanAge index, 7.5 years less when compared to competing athletes, and 7.4 years less when compared to the inactive population. Furthermore, results supported the association of the COL12A1, COL27A1, Tenascin C and matrix-metalloproteinase 3 (MMP3) gene variants with either increased or reduced risk of developing anterior cruciate ligament ruptures or Achilles tendinopathies, types of injuries that are common in sport, impacting both professional competing athletes and recreational exercisers.
Abstract (croatian)
Redovna umjerena tjelesna aktivnost blagotvorno utječe na cjelokupno zdravlje. Trenutno se još uvijek zna jako malo o utjecaju vježbanja na glikozilaciju imunoglobulina G (IgG). U ovom doktorskom radu cilj je bio istražiti utjecaj učestalosti treniranja na glikanske biomarkere biološke dobi, kao i povezanost trenutno poznatih varijanti gena s ozljedama mekog vezivnog tkiva kod sportaša. Značajno niži GlycanAge indeks potvrđen je u grupi redovnih umjerenih vježbača, dok su profesionalni sportaši i neaktivna popoulacija imali značajno viši GlycanAge indeks. Osim toga, postoji značajna povezanost genskih varijanti unutar COL12A1, COL27A1, Tenascin C (TNC) i matriks-metaloproteinaza 3 (MMP3) gena s povišenim ili smanjenim rizikom od nastanka rupture prednjeg križnog ligamenta i tendinopatija u Ahilovoj tetivi, kod profesionalnih sportaša u odnosu na kontrolnu skupinu. Ozljede ligamenata i tetiva su česte sportske ozljede koje pogađaju i rekreativne i profesionalne sportaše.
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:217:649248
Promotion2024
ProjectNumber: IR_2015_28
Title: Istraživanje genskih predispozicija i razvoj testa za prevenciju sportskih ozljeda - GENPrevent
Title: Research on genetic predispositions and development of a test for the prevention of sports injuries
Acronym: GENPrevent
Leader: Gordan Lauc
Jurisdiction: Croatia
Funder: Hrvatska agencija za malo gospodarstvo, inovacije i investicije
Study programmeTitle: Doctoral study
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti u području prirodnih znanosti (doktor/doktorica znanosti u području prirodnih znanosti)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-09-03 11:30:58