prikaz prve stranice dokumenta Uloga moždanoga neurotrofnoga čimbenika u razvoju koronarne bolesti srca u pretilih osoba
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doctoral thesis
Uloga moždanoga neurotrofnoga čimbenika u razvoju koronarne bolesti srca u pretilih osoba
Zagreb: University of Zagreb, Faculty of Science, 2015. urn:nbn:hr:217:056950
Šustar, Aleksandra
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Šustar, A. (2015). Uloga moždanoga neurotrofnoga čimbenika u razvoju koronarne bolesti srca u pretilih osoba (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:056950

Šustar, Aleksandra. "Uloga moždanoga neurotrofnoga čimbenika u razvoju koronarne bolesti srca u pretilih osoba." Doctoral thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:056950

Šustar, Aleksandra. "Uloga moždanoga neurotrofnoga čimbenika u razvoju koronarne bolesti srca u pretilih osoba." Doctoral thesis, University of Zagreb, Faculty of Science, 2015. https://urn.nsk.hr/urn:nbn:hr:217:056950

Šustar, A. (2015). 'Uloga moždanoga neurotrofnoga čimbenika u razvoju koronarne bolesti srca u pretilih osoba', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 09 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:056950

Šustar A. Uloga moždanoga neurotrofnoga čimbenika u razvoju koronarne bolesti srca u pretilih osoba [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2015 [cited 2024 November 09] Available at: https://urn.nsk.hr/urn:nbn:hr:217:056950

A. Šustar, "Uloga moždanoga neurotrofnoga čimbenika u razvoju koronarne bolesti srca u pretilih osoba", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2015. Available at: https://urn.nsk.hr/urn:nbn:hr:217:056950

Metadata
TitleUloga moždanoga neurotrofnoga čimbenika u razvoju koronarne bolesti srca u pretilih osoba
Title (english)The role of brain derived neurotrophic factor in development of coronary heart disease in obese patients
AuthorAleksandra Šustar
MentorNela Pivac (mentor)
MBZ: 113176
Committee memberDubravka Švob Štrac (član povjerenstva)
Committee memberDubravka Hranilović (član povjerenstva)
Committee memberBoris Brkljačić (član povjerenstva)
MBZ: 175585
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2015, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		57 - Biological sciences. Physical anthropology. Biodiversity
Abstract
Moždani neurotrofni čimbenik (BDNF) je neutrofin s važnom ulogom u regulaciji tjelesne mase i pretilosti. Pretilost je važan čimbenik rizika za koronarnu bolest srca (KBS). Cilj je bio istražiti povezanost između KBS, pretilosti i koncentracije BDNF-a u plazmi i raspodjele genotipova Val66Met gena BDNF, te utjecaj rizičnih čimbenika za razvoj KBS i pretilosti, kod osoba s KBS i zdravih kontrolnih ispitanika. Koncentracija BDNF-a u plazmi bila je značajno niža kod osoba s KBS prema zdravim ispitanicima, ali se nije razlikovala između pretilih i nepretilih ispitanika, kao niti između nosioca različitih genotipova Val66Met gena BDNF. Raspodjela genotipova Val66Met gena BDNF bila je slična kod osoba s ili bez KBS i/ili pretilosti. Rizični čimbenici/pokazatelji za razvoj KBS bili su koncentracije BDNF-a, glukoze, HDL-kolesterola i opseg struka, a za pretilost samo opseg struka. Rezultati upućuju na ulogu BDNF-a u KBS i njegovu potencijalnu primjenu u dijagnostici KBS, no ne i pretilosti.
Abstract (english)
Brain derived neurotrophic factor (BDNF) is a neurotrophin with important role in regulation of body weight and obesity. Obesity is a substantial risk factor for coronary heart disease (CHD). Aim was to determine the association between CHD, obesity and plasma BDNF concentration and BDNF Val66Met genotype frequency, and the influence of risk factors for development of CHD and obesity, in subjects with CHD and healthy control subjects. Plasma BDNF concentration was significantly lower in CHD patients than in control subjects, but did not differ between obese and non-obese subjects, or between different BDNF Val66Met genotype carriers. BDNF Val66Met genotype frequency was similar in subjects with or without CHD and/or obesity. Risk factors/indicators for CHD were concentrations of BDNF, glucose, HDL-cholesterol and waist circumference, and for obesity only waist circumference. The results suggest the role of BDNF in CHD and its potential application in the diagnosis of CHD, but not in obesity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:056950
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsClosed access
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Created on2017-05-17 11:22:49