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undergraduate thesis
Upotreba biljnih stanica za proizvodnju terapeutskih glikoproteina
Zagreb: University of Zagreb, Faculty of Science, 2024. urn:nbn:hr:217:634196
Begović, Erin
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Begović, E. (2024). Upotreba biljnih stanica za proizvodnju terapeutskih glikoproteina (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:634196

Begović, Erin. "Upotreba biljnih stanica za proizvodnju terapeutskih glikoproteina." Undergraduate thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:634196

Begović, Erin. "Upotreba biljnih stanica za proizvodnju terapeutskih glikoproteina." Undergraduate thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:634196

Begović, E. (2024). 'Upotreba biljnih stanica za proizvodnju terapeutskih glikoproteina', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 28 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:634196

Begović E. Upotreba biljnih stanica za proizvodnju terapeutskih glikoproteina [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2024 [cited 2024 November 28] Available at: https://urn.nsk.hr/urn:nbn:hr:217:634196

E. Begović, "Upotreba biljnih stanica za proizvodnju terapeutskih glikoproteina", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:217:634196

Metadata
TitleUpotreba biljnih stanica za proizvodnju terapeutskih glikoproteina
Title (english)Plant cell based production of therapeutic glycoproteins
AuthorErin Begović
MentorBiljana Balen (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2024-07-19, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Mnogi terapeutici kao što su cjepiva, antitijela i rekombinantni proteini po sastavu su glikoproteini. Biljne stanice sve se češće koriste za proizvodnju rekombinantnih terapeutskih glikoproteina jer nude određene prednosti pred animalnim i prokariotskim stanicama. Glavno svojstvo koje im omogućuje sintezu glikoproteinskih terapeutika je sposobnost N- i Oglikozilacije. Ipak, korištenje biljnih stanica u te svrhe ima i svojih nedostataka. Glikoproteini proizvedeni u biljnim stanicama mogu sadržavati karakteristične biljne epitope koji u ljudskom organizmu mogu dovesti do alergije, a postoji i problem brzog klirensa glikoproteinskog terapeutika iz ljudskog seruma, čime se smanjuje njegova učinkovitost. Ovi izazovi nadilaze se raznim tehnikama kao što su inaktivacija i/ili ubacivanje specifičnih gena u biljne stanice
Abstract (english)
Many therapeutics such as vaccines, antibodies, and recombinant proteins are glycoproteins. The use of plant cells for the production of recombinant therapeutic glycoproteins is constantly increasing due to certain advantages of plant cells over animal and prokaryotic cells. The main property that enables them to synthesize glycoprotein therapeutics is their ability to perform N- and O-glycosylation. However, using plant cells for these purposes also has its disadvantages. Glycoproteins produced in plant cells can contain characteristic plant epitopes that can cause allergic reactions in the human body. There is also a problem of the rapid clearance of the glycoprotein therapeutics from human serum, which reduces its effectiveness. These challenges are overcomed through various techniques such as inactivation and/or insertion of specific genes into plant cells.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:634196
Study programmeTitle: Molecular biology-University undergraduate programme
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-09-03 12:33:12