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doctoral thesis
Uloga proteina FADD u regulaciji stanične smrti
Zagreb: University of Zagreb, Faculty of Science, 2014. urn:nbn:hr:217:573841
Antunović, Maja
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Antunović, M. (2014). Uloga proteina FADD u regulaciji stanične smrti (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:573841

Antunović, Maja. "Uloga proteina FADD u regulaciji stanične smrti." Doctoral thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:573841

Antunović, Maja. "Uloga proteina FADD u regulaciji stanične smrti." Doctoral thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:573841

Antunović, M. (2014). 'Uloga proteina FADD u regulaciji stanične smrti', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 29 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:573841

Antunović M. Uloga proteina FADD u regulaciji stanične smrti [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2014 [cited 2024 November 29] Available at: https://urn.nsk.hr/urn:nbn:hr:217:573841

M. Antunović, "Uloga proteina FADD u regulaciji stanične smrti", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:217:573841

Metadata
TitleUloga proteina FADD u regulaciji stanične smrti
Title (english)The role of FADD protein in cell death
AuthorMaja Antunović
MentorInga Marijanović (mentor)
Committee memberMaja Matulić (član povjerenstva)
Committee memberMaja Osmak (član povjerenstva)
Committee memberVera Garaj-Vrhovac (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2014, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
Vođeni pretpostavkom da protein FADD (engl. Fas-Associated protein with Death Domain) sudjeluje u prijenosu apoptotskih, nekroptotskih i autofagnih signala nakon primjene NB-UVB (engl. Narrowband Ultraviolet B) zračenja, istražili smo njegovu ulogu smrtonosnog adaptera na modelu mišjih embrionalnih fibroblasta koji nemaju gen za protein FADD. Rezultati ovog istraživanja pokazuju da divlji tip mišjih embrionalnih fibroblasta umire apoptotskim smrtonosnim mehanizmom nakon izlaganja NB-UVB zračenju i to aktivacijom mitohondrijskog puta, ali bez aktivacije proteina p53. Stanice koje nemaju gen za protein FADD nakon izlaganja NB-UVB zračenju umiru programiranom nekrozom i autofagijom, uz aktivaciju kaspaza 3 i 9, ali bez aktivacije proteina p53, Bax i Bcl-2. Rezultati ukazuju da su protein FADD, ali i kinaza RIP1 (engl. Receptor-interacting serine/threonine-protein kinase 1) nužni za pokretanje apoptotskog smrtonosnog mehanizma, dok protein FADD nije nužan za aktivaciju autofagije koja se javlja zajedno s programiranom nekrozom nakon izlaganja stanica NB-UVB zračenju.
Abstract (english)
Based on the presumption that FADD protein (Fas-Associated protein with Death Domain) intermediates apoptotic, necroptotic and autophagic signals after exposure to NB-UVB (Narrowband Ultraviolet B) irradiation, we tested its role of death adaptor using FADD knockout mouse embrionic fibroblasts. The results show that wild type mouse embryonic fibroblast die by triggering apoptotic death signals through mitochondrial control, but independently of p53. FADD knockout mouse embrionic fibroblasts die by programmed necrosis and autophagy, by activating caspase-3 and -9. Their necrotic programme does not involve p53 nor Bax and Bcl-2. The results show that protein FADD, as well as RIPK1 (Receptor-interacting serine/threonine-protein kinase 1), are essential for triggering apoptotic cell death mechanism. FADD protein is not necessary for autophagic mechanism followed by necroptosis after NB-UVB irradiation.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:573841
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-05-17 12:00:06