prikaz prve stranice dokumenta Light‐Controlled Electric Stimulation with Organic Electrolytic Photocapacitors Achieves Complex Neuronal Network Activation: Semi‐Chronic Study in Cortical Cell Culture and Rat Model
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Scientific paper - Original scientific paper
Light‐Controlled Electric Stimulation with Organic Electrolytic Photocapacitors Achieves Complex Neuronal Network Activation: Semi‐Chronic Study in Cortical Cell Culture and Rat Model
Advanced Healthcare Materials, 2024 (2024); 2401303. https://doi.org/10.1002/adhm.202401303
Nowakowska, Marta; Jakešová, Marie; Schmidt, Tony; Opančar, Aleksandar; Polz, Mathias; Reimer, Robert; Fuchs, Julia; Patz, Silke; Ziesel, Daniel; Scheruebel, Susanne; Kornmueller, Karin; Rienmüller, Theresa; Đerek, Vedran; Głowacki, Eric D.; Schindl, Rainer; Üçal, Muammer More authors...

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Nowakowska, M., Jakešová, M., Schmidt, T., Opančar, A., Polz, M., Reimer, R. ... Üçal, M. (2024). Light‐Controlled Electric Stimulation with Organic Electrolytic Photocapacitors Achieves Complex Neuronal Network Activation: Semi‐Chronic Study in Cortical Cell Culture and Rat Model. Advanced Healthcare Materials, 2024.. doi: 10.1002/adhm.202401303

Nowakowska, Marta, et al. "Light‐Controlled Electric Stimulation with Organic Electrolytic Photocapacitors Achieves Complex Neuronal Network Activation: Semi‐Chronic Study in Cortical Cell Culture and Rat Model." Advanced Healthcare Materials, vol. 2024, 2024. https://doi.org/10.1002/adhm.202401303

Nowakowska, Marta, Marie Jakešová, Tony Schmidt, Aleksandar Opančar, Mathias Polz, Robert Reimer, Julia Fuchs, et al. "Light‐Controlled Electric Stimulation with Organic Electrolytic Photocapacitors Achieves Complex Neuronal Network Activation: Semi‐Chronic Study in Cortical Cell Culture and Rat Model." Advanced Healthcare Materials 2024 (2024). https://doi.org/10.1002/adhm.202401303

Nowakowska, M., et al. (2024) 'Light‐Controlled Electric Stimulation with Organic Electrolytic Photocapacitors Achieves Complex Neuronal Network Activation: Semi‐Chronic Study in Cortical Cell Culture and Rat Model', Advanced Healthcare Materials, 2024. doi: 10.1002/adhm.202401303

Nowakowska M, Jakešová M, Schmidt T, Opančar A, Polz M, Reimer R, and sur.. Light‐Controlled Electric Stimulation with Organic Electrolytic Photocapacitors Achieves Complex Neuronal Network Activation: Semi‐Chronic Study in Cortical Cell Culture and Rat Model. Advanced Healthcare Materials [Internet]. 2024 August 13 [cited 2024 December 23];2024. doi: 10.1002/adhm.202401303

M. Nowakowska, et al., "Light‐Controlled Electric Stimulation with Organic Electrolytic Photocapacitors Achieves Complex Neuronal Network Activation: Semi‐Chronic Study in Cortical Cell Culture and Rat Model", Advanced Healthcare Materials, vol. 2024, August 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:217:512424. [Accessed: 23 December 2024]

Metadata
Title (english)Light‐Controlled Electric Stimulation with Organic Electrolytic Photocapacitors Achieves Complex Neuronal Network Activation: Semi‐Chronic Study in Cortical Cell Culture and Rat Model
AuthorMarta Nowakowska
AuthorMarie Jakešová
AuthorTony Schmidt
AuthorAleksandar Opančar
AuthorMathias Polz
AuthorRobert Reimer
AuthorJulia Fuchs
AuthorSilke Patz
AuthorDaniel Ziesel
AuthorSusanne Scheruebel
AuthorKarin Kornmueller
AuthorTheresa Rienmüller
AuthorVedran Đerek
AuthorEric D. Głowacki
AuthorRainer Schindl
AuthorMuammer Üçal
Author's institutionUniversity of Zagreb
Faculty of Science
(Department of Physics)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Abstract (english)
Neurostimulation employing photoactive organic semiconductors offers an appealing alternative to conventional techniques, enabling targeted action and wireless control through light. In this study, organic electrolytic photocapacitors (OEPC) are employed to investigate the effects of light‐controlled electric stimulation on neuronal networks in vitro and in vivo. The interactions between the devices and biological systems are characterized. Stimulation of primary rat cortical neurons results in an elevated expression of c‐Fos within a mature neuronal network. OEPC implantation for three weeks and subsequent stimulation of the somatosensory cortex leads to an increase of c‐Fos in neurons at the stimulation site and in connected brain regions (entorhinal cortex, hippocampus), both in the ipsi‐ and contralateral hemispheres. Reactivity of glial and immune cells after semi‐chronic implantation of OEPC in the rat brain is comparable to that of surgical controls, indicating minimal foreign body response. Device functionality is further substantiated through retained charging dynamics following explantation. OEPC‐based, light‐controlled electric stimulation has a significant impact on neural responsiveness. The absence of detrimental effects on both the brain and device encourages further use of OEPC as cortical implants. These findings highlight its potential as a novel mode of neurostimulation and instigate further exploration into applications in fundamental neuroscience.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAdvanced Healthcare Materials
Numberingvol. 2024, 2401303
p-ISSN2192-2640
e-ISSN2192-2659
DOIhttps://doi.org/10.1002/adhm.202401303
URN:NBNurn:nbn:hr:217:512424
Publication2024-08-13
ProjectNumber: UIP-2019-04-1753
Title (croatian): Mikro i nano-strukture za 3D opto-bioelektroniku
Title (english): Micro- and nano-structures for 3D opto-bioelectronics
Acronym: 3Doptobio
Leader: Vedran Đerek
Jurisdiction: Croatia
Funding stream: Installation Research Projects
ProjectNumber: KK.01.1.1.02.0013
Title (croatian): Centar za Napredna Istraživanja Kompleksnih Sustava
Title (english): Centre for Advanced Research of Complex Systems
Acronym: CeNIKS
Leader: Mihael Srđan Grbić
Jurisdiction: eu
Funding stream: European Regional Development Fund
ProjectNumber: KK.01.1.1.01.0004
Title (croatian): Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri
Title (english): Implementation of top research within the Scientific Center of Excellence for Quantum and Complex Systems, and Representations of Lie Algebras
Acronym: QuantiXLie
Leader: Hrvoje Buljan
Jurisdiction: eu
Funding stream: European Regional Development Fund
Document URLhttps://onlinelibrary.wiley.com/doi/10.1002/adhm.202401303
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Public note© 2024 The Author(s). Advanced Healthcare Materials published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Received: April 9, 2024. Revised: August 5, 2024. Published online: 13 August 2024.
Created on2024-09-12 12:50:05