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undergraduate thesis
Interakcije crijevnog mikrobioma i imunološkog sustava
Zagreb: University of Zagreb, Faculty of Science, 2024. urn:nbn:hr:217:449421
Pauli, Katarina
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Pauli, K. (2024). Interakcije crijevnog mikrobioma i imunološkog sustava (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:449421

Pauli, Katarina. "Interakcije crijevnog mikrobioma i imunološkog sustava." Undergraduate thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:449421

Pauli, Katarina. "Interakcije crijevnog mikrobioma i imunološkog sustava." Undergraduate thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:449421

Pauli, K. (2024). 'Interakcije crijevnog mikrobioma i imunološkog sustava', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:449421

Pauli K. Interakcije crijevnog mikrobioma i imunološkog sustava [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2024 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:449421

K. Pauli, "Interakcije crijevnog mikrobioma i imunološkog sustava", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:217:449421

Metadata
TitleInterakcije crijevnog mikrobioma i imunološkog sustava
Title (english)Interactions between the gut microbiome and the immune system
AuthorKatarina Pauli
MentorZoran Tadić (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2024-09-02, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Crijevo je jedno od najvećih imunoloških organa koje svojom sluznicom djeluju kao barijera protiv prodora patogena, istovremeno esencijalno je za održavanje komunikacije imunološkog sustava i crijevnog mikrobioma. Crijevni mikrobiom zajednica je brojnih bakterija, virusa i gljivica koji na razne načine utječu na imunološki odgovor. Bakterije svojim metabolitima reguliraju proliferaciju, diferencijaciju i funkcionalnost imunoloških stanica. Svojim utjecajem na imunološki sustav promiču homeostazu crijeva ili pogoršavaju upalne procese. Jedna vrsta bakterijskih metabolita, kratkolančane masne kiseline (eng. short-chain fatty acids, dalje: SCFA), pokazale su se kao važni medijatori upalnih procesa. SCFA-producirajuće bakterije dominiraju zdravim crijevom. Međutim, različiti čimbenici uzrokuju promjene u sastavu mikrobioma, gdje se povećava kolonizacija patogena, što dovodi do disbioze crijeva. Disbioza crijeva povezana je s patogenezom različitih bolesti i povećanoj podložnosti zarazama. S obzirom na to da se svakim novim istraživanjem interakcije crijevnog mikrobioma i imunološkog sustava pokazuju esencijalnim za zdravlje cijelog organizma, istraživanje ovog područja vrlo je važno za proučavanje patogeneze bolesti povezanih s disbiozom i razvojem novih lijekova i tretmana.
Abstract (english)
The intestine is one of the largest immune organs, its mucosa acts as a barrier against the penetration of pathogens. It is also essential for maintaining communication between the immune system and the gut microbiome. The gut microbiome is a big community of bacteria, viruses and fungi that influence the immune response in various ways. Bacteria regulate the proliferation, differentiation and functionality of immune cells with their metabolites. Through their influence on the immune system, they promote gut homeostasis or worsen inflammatory processes. One type of bacterial metabolites, short-chain fatty acids (SCFA), have shown to be important mediators of inflammatory processes. SCFA-producing bacteria dominate the healthy gut, however various factors cause changes in the composition of the microbiome where pathogen colonization increases causing gut dysbiosis. Gut dysbiosis is associated with the pathogenesis of various diseases and increased susceptibility to infections. New studies show that the interaction between the gut microbiome and the immune system is essential for the health of the whole organism, research in this area is critical for the understanding of the pathogenesis of dysbiosis-related diseases and the development of new drugs and treatments.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:449421
Study programmeTitle: Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-09-12 17:02:24