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Scientific paper - Original scientific paper
Biomechanics of chromosome alignment at the spindle midplane
Current Biology, 31 (2021), 10; R574-R585. https://doi.org/10.1016/j.cub.2021.03.082
Risteski, Patrik; Jagrić, Mihaela; Pavin, Nenad; Tolić, Iva M.

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Risteski, P., Jagrić, M., Pavin, N. & Tolić, I. M. (2021). Biomechanics of chromosome alignment at the spindle midplane. Current Biology, 31. (10), R574-R585. doi: 10.1016/j.cub.2021.03.082

Risteski, Patrik, et al. "Biomechanics of chromosome alignment at the spindle midplane." Current Biology, vol. 31, no. 10, 2021, pp. R574-R585. https://doi.org/10.1016/j.cub.2021.03.082

Risteski, Patrik, Mihaela Jagrić, Nenad Pavin and Iva M. Tolić. "Biomechanics of chromosome alignment at the spindle midplane." Current Biology 31, no. 10 (2021): R574-R585. https://doi.org/10.1016/j.cub.2021.03.082

Risteski, P., et al. (2021) 'Biomechanics of chromosome alignment at the spindle midplane', Current Biology, 31(10), pp. R574-R585. doi: 10.1016/j.cub.2021.03.082

Risteski P, Jagrić M, Pavin N, Tolić IM. Biomechanics of chromosome alignment at the spindle midplane. Current Biology [Internet]. 2021 [cited 2024 November 25];31(10):R574-R585. doi: 10.1016/j.cub.2021.03.082

P. Risteski, M. Jagrić, N. Pavin and I. M. Tolić, "Biomechanics of chromosome alignment at the spindle midplane", Current Biology, vol. 31, no. 10, pp. R574-R585, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:217:282169. [Accessed: 25 November 2024]

Metadata
Title (english)Biomechanics of chromosome alignment at the spindle midplane
AuthorPatrik Risteski
AuthorMihaela Jagrić
AuthorNenad Pavin
AuthorIva M. Tolić
Author's institutionUniversity of Zagreb
Faculty of Science
(Department of Physics)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Abstract (english)
During metaphase, chromosomes are aligned in a lineup at the equatorial plane of the spindle to ensure synchronous poleward movement of chromatids in anaphase and proper nuclear reformation at the end of mitosis. Chromosome alignment relies on microtubules, several types of motor protein and numerous other microtubule- associated and regulatory proteins. Because of the multitude of players involved, the mechanisms of chromosome alignment are still under debate. Here, we discuss the current models of alignment based on poleward pulling forces exerted onto sister kinetochores by kinetochore microtubules, which show length-dependent dynamics and undergo poleward flux, and polar ejection forces that push the chromosome arms away from the pole. We link these models with the recent ideas based on mechanical coupling between bridging and kinetochore microtubules, where sliding of bridging microtubules promotes overlap length-dependent sliding of kinetochore fibers and thus the alignment of sister kinetochores at the spindle equator. Finally, we discuss theoretical models of forces acting on chromosomes during metaphase.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCurrent Biology
Numberingvol. 31, no. 10, pp. R574-R585
p-ISSN0960-9822
DOIhttps://doi.org/10.1016/j.cub.2021.03.082
URN:NBNurn:nbn:hr:217:282169
Publication2021
ProjectNumber: 855158
Title (croatian): Molekularno podrijetlo aneuploidija u zdravim i bolesnim ljudskim tkivima
Title (english): Molecular origins of aneuploidies in healthy and diseased human tissues
Acronym: ANEUPLOIDY
Leader: Iva Marija Tolić
Jurisdiction: eu
ProjectNumber: 647077
Title (croatian): Nova klasa mikrotubula u vretenu koja djeluje silama na kinetohore
Title (english): A new class of microtubules in the spindle exerting forces on kinetochores
Acronym: NewSpindleForce
Leader: Iva Marija Tolić
Jurisdiction: eu
ProjectNumber: IP-2019-04-5967
Title (croatian): Ravnoteža sila i momenta sila u diobenom vretenu
Title (english): Balance of forces and torques in the mitotic spindle
Acronym: SpindleForceBalance
Leader: Nenad Pavin
Jurisdiction: Croatia
Funding stream: Research Projects
ProjectNumber: KK.01.1.1.04.0057
Title (croatian): Inovativni protokoli mikroskopije za interdisciplinarna istraživanja u biomedicini
Title (english): Inovative microscopy protocols for interdisciplinary research in biomedicine
Acronym: IPSted
Leader: Iva Marija Tolić
Jurisdiction: eu
Funding stream: European Regional Development Fund
ProjectNumber: KK.01.1.1.01.0004
Title (croatian): Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri
Title (english): Implementation of top research within the Scientific Center of Excellence for Quantum and Complex Systems, and Representations of Lie Algebras
Acronym: QuantiXLie
Leader: Hrvoje Buljan
Jurisdiction: eu
Funding stream: European Regional Development Fund
ProjectNumber: PZS-2019-02-7653
Title (croatian): Mehanizmi nastajanja snopova mikrotubula potrebni za sazrijevanje diobenog vretena
Title (english): Mechanisms of microtubule bundle formation required for spindle maturation
Acronym: SpindleForm
Leader: Iva Marija Tolić
Jurisdiction: Croatia
Funding stream: Programme Research Cooperability
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0960982221004553
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Public note© 2021 Elsevier Inc. Published 24 May 2021. The Creative Commons licensing terms apply.
Created on2024-09-14 21:04:45