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doctoral thesis
Polimorfizmi gena za apolipoprotein A5 i protein-nosač masnih kiselina 2 u metaboličkom sindromu starije populacije
Zagreb: University of Zagreb, Faculty of Science, 2016. urn:nbn:hr:217:437376
Feher Turković, Lana
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Feher Turković, L. (2016). Polimorfizmi gena za apolipoprotein A5 i protein-nosač masnih kiselina 2 u metaboličkom sindromu starije populacije (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:437376

Feher Turković, Lana. "Polimorfizmi gena za apolipoprotein A5 i protein-nosač masnih kiselina 2 u metaboličkom sindromu starije populacije." Doctoral thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:437376

Feher Turković, Lana. "Polimorfizmi gena za apolipoprotein A5 i protein-nosač masnih kiselina 2 u metaboličkom sindromu starije populacije." Doctoral thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:437376

Feher Turković, L. (2016). 'Polimorfizmi gena za apolipoprotein A5 i protein-nosač masnih kiselina 2 u metaboličkom sindromu starije populacije', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:437376

Feher Turković L. Polimorfizmi gena za apolipoprotein A5 i protein-nosač masnih kiselina 2 u metaboličkom sindromu starije populacije [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2016 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:217:437376

L. Feher Turković, "Polimorfizmi gena za apolipoprotein A5 i protein-nosač masnih kiselina 2 u metaboličkom sindromu starije populacije", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:217:437376

Metadata
TitlePolimorfizmi gena za apolipoprotein A5 i protein-nosač masnih kiselina 2 u metaboličkom sindromu starije populacije
Title (english)Gene polymorphisms of the apolipoprotein A5 and the fatty acid-binding protein 2 in the metabolic syndrome of the elderly subjects
AuthorLana Feher Turković
MentorDaria Pašalić (mentor)
MBZ: 219382
Committee memberJasmina Rokov Plavec (predsjednik povjerenstva)
Committee memberDaria Pašalić (član povjerenstva)
MBZ: 219382
Committee memberDomagoj Đikić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2016-12-21, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Universal decimal classification
(UDC)		54 - Chemistry. Crystallography. Mineralogy
Abstract
Metabolički sindrom (MetS) je poremećaj za čiji razvoj je odgovoran cijeli niz čimbenika kao što su dislipidemija, abdominalna pretilost, hipertenzija i hiperglikemija. U čimbenike rizika ubrajaju se i genetički čimbenici. Kako bi se utvrdilo da li promjene u strukturi gena za apolipoprotein A5 (ApoA5) i protein-nosač masnih kiselina 2 (FABP2) koji sudjeluju u izvanstaničnom/unutarstaničnom transportu lipida utječu na nastanak MetS u starijoj populaciji, provedeno je istraživanje na 345 ispitanika muškog i ženskog spola starosti od 70 do 93 godine. Za svakog su ispitanika utvrđene antropometrijske vrijednosti, a biokemijskim su analizama određeni parametri lipidnog statusa u serumu, kao i koncentracija glukoze, ukupni proteini i C-reaktivni protein. Genotipizacija odabranih gena provedena je metodama temeljenim na lančanoj reakciji polimerazom. Plinskom kromatografijom određen je sastav i koncentracije masnih kiselina u ispitanika s i bez MetS. Statističkom je analizom utvrđeno da genske varijante gena za ApoA5 i gena za FABP2 nisu povezane s povećanim rizikom za razvoj metaboličkog sindroma. Međutim, polimorfizmi gena za ApoA5 i gena za FABP2 mogu biti povezani s koncentracijama lipida u serumu starije populacije s metaboličkim sindromom. Zaključak je da bi se stoga ApoA5 i FABP2 mogli razmotriti kao čimbenici patobiokemije multifaktorijalnih poremećaja poput MetS.
Abstract (english)
Metabolic syndrome (MetS) is a multifactorial disorder. Among the risk factors for developing MetS are dyslipidemia, abdominal obesity, hypertension and hyperglycemia. The other risk factors include also the genetic factors. To determine whether changes in the structure of the gene for apolipoprotein A5 (ApoA5) and the fatty acid-binding protein 2 (FABP2), that participate in the extracellular / intracellular transport of lipids influence the occurrence of MetS in older population, an investigation was conducted on 345 subjects, males and females, aged 70-93 years. For each subject were determined the anthropometric values. The concentrations of glucose, total protein and C-reactive protein were determined in serum by biochemical methods. Genotyping of selected genes was carried out by methods based on the polymerase chain reaction. The composition and concentration of fatty acids in subjects with and without MetS were determined by gas chromatography. Statistical analysis showed that genetic variants of ApoA5 gene and FABP2 gene were not associated with an increased risk for developing metabolic syndrome. However, ApoA5 and FABP2 gene polymorphisms may be associated with serum lipid levels in an elderly population with MetS. The conclusion is that the ApoA5 and FABP2 could be considered as factors for pathobiochemistry of multifactorial disorders such as MetS.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:437376
Study programmeTitle: Doctoral study in chemistry
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija (doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija)
Type of resourceText
Extent164 str. ; 30 cm
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-02-02 16:38:40