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doctoral thesis
Duljina telomera i imunoreaktivnost u posttraumatskom stresnom poremećaju
Zagreb: University of Zagreb, Faculty of Science, 2014. urn:nbn:hr:217:427089
Jergović, Mladen
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Jergović, M. (2014). Duljina telomera i imunoreaktivnost u posttraumatskom stresnom poremećaju (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:427089

Jergović, Mladen. "Duljina telomera i imunoreaktivnost u posttraumatskom stresnom poremećaju." Doctoral thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:427089

Jergović, Mladen. "Duljina telomera i imunoreaktivnost u posttraumatskom stresnom poremećaju." Doctoral thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:427089

Jergović, M. (2014). 'Duljina telomera i imunoreaktivnost u posttraumatskom stresnom poremećaju', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:427089

Jergović M. Duljina telomera i imunoreaktivnost u posttraumatskom stresnom poremećaju [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2014 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:427089

M. Jergović, "Duljina telomera i imunoreaktivnost u posttraumatskom stresnom poremećaju", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:217:427089

Metadata
TitleDuljina telomera i imunoreaktivnost u posttraumatskom stresnom poremećaju
Title (english)Telomere length and immunoreactivity in posttraumatic stress disorder
AuthorMladen Jergović
MentorKrešo Bendelja (mentor)
MentorAnđelko Vidović (sumentor)
Committee memberIvica Rubelj (član povjerenstva)
Committee memberNada Oršolić (član povjerenstva)
Committee memberNeda Slade (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2014, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
Sve je više dokaza da kronični stres ubrzava skraćivanje telomera u leukocitima i mononuklearnim stanicama iz periferne krvi. Funkcionalne posljedice skraćivanja telomera nisu razjašnjene. U ovom istraživanju mjerena je duljina telomera i aktivnost telomeraze u mononuklearnim stanicama iz periferne krvi 62 osobe: (pacijenti oboljeli od posttraumatskog stresnog poremećaja (PTSP) (N = 30); zdrave kontrole (N = 17), starije osobe (N = 15)). Paralelno, izmjerena je proliferacija aktiviranih T-limfocita i njihova proizvodnja citokina interferona (IFN)-γ, interleukina (IL)-2, IL-4; proizvodnja faktora nekroze tumora (TNF)-α i IL-6 od strane monocita te izraženost receptora programmed death 1 (PD-1) i njegovog liganda PD-L1 na aktiviranim T-limfocitima. Ovo istraživanje pridonosi rastućem broju dokaza da psihološka trauma i kronični stres doprinose skraćivanju telomera. Iako manje izraženi kod pacijenata oboljelih od PTSP-a nego kod starijih osoba, smanjeni proliferativni odgovori T-limfocita i kraća duljina telomera mogli bi biti znakovi rane imunosenescencije. Zajedno sa smanjenom proizvodnjom Th1-citokina, ove promjene imunološkog sustava mogle bi doprinijeti zdravstvenim rizicima povezanim s PTSP-om.
Abstract (english)
There is increasing evidence that chronic stress accelerates telomere erosion in leukocytes/ peripheral blood mononuclear cells (PBMCs). However, functional changes associated with telomere shortening are poorly understood. We measured relative telomere length and basal telomerase activity in PBMCs of 62 individuals (patients with posttraumatic stress disorder (PTSD) (N=30); age-matched healthy controls (N=17), elderly volunteers (N=15)). In parallel, we have assessed proliferation of activated T cells, interferon (IFN)-γ, interleukin (IL)-2, IL-4, tumor necrosis factor (TNF)-α and IL-6 cytokine production and expression of programmed death 1 (PD-1) receptor and its ligand PD-L1 on activated T cells. This study adds to the accumulating evidence that psychological trauma and chronic stress are associated with accelerated telomere attrition. Although much less pronounced in PTSD patients than in elderly persons, reduced proliferative responses of T cells accompanied by shorter telomeres might be a sign of early immunosenescence. Together with reduced production of Th1 cytokines, observed immune changes may contribute to health risks associated with PTSD.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:427089
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-05-18 09:27:36