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master's thesis
Procjena 3-hidroksi-2-piridinskih oksima kao mogućih protutumorskih lijekova
Zagreb: University of Zagreb, Faculty of Science, 2024. urn:nbn:hr:217:364641
Jurić, Matea
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Jurić, M. (2024). Procjena 3-hidroksi-2-piridinskih oksima kao mogućih protutumorskih lijekova (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:364641

Jurić, Matea. "Procjena 3-hidroksi-2-piridinskih oksima kao mogućih protutumorskih lijekova." Master's thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:364641

Jurić, Matea. "Procjena 3-hidroksi-2-piridinskih oksima kao mogućih protutumorskih lijekova." Master's thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:364641

Jurić, M. (2024). 'Procjena 3-hidroksi-2-piridinskih oksima kao mogućih protutumorskih lijekova', Master's thesis, University of Zagreb, Faculty of Science, accessed 28 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:364641

Jurić M. Procjena 3-hidroksi-2-piridinskih oksima kao mogućih protutumorskih lijekova [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2024 [cited 2024 December 28] Available at: https://urn.nsk.hr/urn:nbn:hr:217:364641

M. Jurić, "Procjena 3-hidroksi-2-piridinskih oksima kao mogućih protutumorskih lijekova", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:217:364641

Metadata
TitleProcjena 3-hidroksi-2-piridinskih oksima kao mogućih protutumorskih lijekova
Title (english)Assessment od 3-hydroxy-2-pyridine oximes as potential anticancer drugs
AuthorMatea Jurić
MentorMaja Katalinić (mentor)
MentorDomagoj Đikić (komentor)
Committee memberDomagoj Đikić (predsjednik povjerenstva)
Committee memberRomana Gračan (član povjerenstva)
Committee memberŽeljka Vidaković-Cifrek (član povjerenstva)
Committee memberVesna Benković (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2024-09-17, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Piridinijevi oksimi se preteņno istraņuju kao protuotrovi kod trovanja organofosfatima, no prema novim istraņivanjima utvrĎeno je da aktiviraju apoptozu u različitim vrstama stanica ńto ih čini zanimljivima i za druge aspekte istraņivanja. U ovom radu ispitan je učinak 3-hidroksi-2-piridinskih oksima prema stanicama raka dojke (MDA-MB-231 i MCF-7) i malignog glioblastoma (U251) u svrhu odreĎivanja njihovog mogućeg protutumorskog potencijala. Testirani oksimi bili su citotoksični za stanice raka dojke i, u manjoj mjeri, za stanice glioblastoma unutar razdoblja izlaganja. Stanična linija MCF-7 bila je najosjetljivija, na koju su sva tri oksima utjecala ovisno o vremenu izloņenosti. Iako je integritet membrane stanica odrņan nakon tretmana, testirani spojevi su utjecali na potencijal mitohondrijske membrane i aktivirali kaspazu 9, odnosno apoptozu posredovanu mitohondrijima. Sveukupno, ovi rezultati sugeriraju da bi istraņivani oksimi mogli posluņiti kao obećavajuća polazna točka za razvoj ciljanih terapija, posebno za rak dojke
Abstract (english)
Pyridinium oximes are mainly studied as antidotes for organophosphate poisoning, but according to new research it has been shown that they activate apoptosis in different types of cells, which makes them interesting for other aspects of research. In this thesis, the effect of 3-hydroxy-2-pyridine oximes on breast cancer cells (MDA-MB-231 and MCF-7) and malignant glioblastoma (U251) was examined in order to determine their possible anticancer potential. The tested oximes were cytotoxic to breast cancer cells and, to a lesser extent, to glioblastoma cells within the exposure period. The MCF-7 cell line was the most sensitive, being affected by all three oximes depending on the exposure time. Although cell membrane integrity was maintained after the treatment, the tested compounds affected the mitochondrial membrane potential and activated caspase 9, which is mitochondria-mediated apoptosis. Overall, these results suggest that the investigated oximes could serve as a promising starting point for the development of targeted therapies, especially for breast cancer.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:364641
Study programmeTitle: Experimental Biology-University graduate programme
Study programme type: university
Study level: graduate
Academic / professional title: sveučilišni/a magistar/magistra eksperimentalne biologije (sveučilišni/a magistar/magistra eksperimentalne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-09-22 10:20:50