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Scientific paper - Review paper
Mitotic spindle: lessons from theoretical modeling
Molecular Biology of the Cell, 32 (2021), 3; 218-222. https://doi.org/10.1091/mbc.E20-05-0335
Tolić, Iva M.; Pavin, Nenad

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Tolić, I. M. & Pavin, N. (2021). Mitotic spindle: lessons from theoretical modeling. Molecular Biology of the Cell, 32. (3), 218-222. doi: 10.1091/mbc.E20-05-0335

Tolić, Iva M. and Nenad Pavin. "Mitotic spindle: lessons from theoretical modeling." Molecular Biology of the Cell, vol. 32, no. 3, 2021, pp. 218-222. https://doi.org/10.1091/mbc.E20-05-0335

Tolić, Iva M. and Nenad Pavin. "Mitotic spindle: lessons from theoretical modeling." Molecular Biology of the Cell 32, no. 3 (2021): 218-222. https://doi.org/10.1091/mbc.E20-05-0335

Tolić, I. M. and Pavin, N. (2021) 'Mitotic spindle: lessons from theoretical modeling', Molecular Biology of the Cell, 32(3), pp. 218-222. doi: 10.1091/mbc.E20-05-0335

Tolić IM, Pavin N. Mitotic spindle: lessons from theoretical modeling. Molecular Biology of the Cell [Internet]. 2021 February 01 [cited 2024 December 29];32(3):218-222. doi: 10.1091/mbc.E20-05-0335

I. M. Tolić and N. Pavin, "Mitotic spindle: lessons from theoretical modeling", Molecular Biology of the Cell, vol. 32, no. 3, pp. 218-222, February 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:217:224215. [Accessed: 29 December 2024]

Metadata
Title (english)Mitotic spindle: lessons from theoretical modeling
AuthorIva M. Tolić
AuthorNenad Pavin
Author's institutionUniversity of Zagreb
Faculty of Science
(Department of Physics)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Abstract (english)
Cell biology is immensely complex. To understand how cells work, we try to find patterns and suggest hypotheses to identify underlying mechanisms. However, it is not always easy to create a coherent picture from a huge amount of experimental data on biological systems, where the main players have multiple interactions or act in redundant pathways. In such situations, when a hypothesis does not lead to a conclusion in a direct way, theoretical modeling is a powerful tool because it allows us to formulate hypotheses in a quantitative manner and understand their consequences. A successful model should not only reproduce the basic features of the system but also provide exciting predictions, motivating new experiments. Much is learned when a model based on generally accepted knowledge cannot explain experiments of interest, as this indicates that the original hypothesis needs to be revised. In this Perspective, we discuss these points using our experiences in combining experiments with theory in the field of mitotic spindle mechanics.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMolecular Biology of the Cell
Numberingvol. 32, no. 3, pp. 218-222
p-ISSN1059-1524
e-ISSN1939-4586
DOIhttps://doi.org/10.1091/mbc.E20-05-0335
URN:NBNurn:nbn:hr:217:224215
Publication2021-02-01
ProjectNumber: PZS-2019-02-7653
Title (croatian): Mehanizmi nastajanja snopova mikrotubula potrebni za sazrijevanje diobenog vretena
Title (english): Mechanisms of microtubule bundle formation required for spindle maturation
Acronym: SpindleForm
Leader: Iva Marija Tolić
Jurisdiction: Croatia
Funding stream: Programme Research Cooperability
ProjectNumber: IP-2019-04-5967
Title (croatian): Ravnoteža sila i momenta sila u diobenom vretenu
Title (english): Balance of forces and torques in the mitotic spindle
Acronym: SpindleForceBalance
Leader: Nenad Pavin
Jurisdiction: Croatia
Funding stream: Research Projects
ProjectNumber: KK.01.1.1.01.0004
Title (croatian): Provedba vrhunskih istraživanja u sklopu Znanstvenog centra izvrsnosti za kvantne i kompleksne sustave te reprezentacije Liejevih algebri
Title (english): Implementation of top research within the Scientific Center of Excellence for Quantum and Complex Systems, and Representations of Lie Algebras
Acronym: QuantiXLie
Leader: Hrvoje Buljan
Jurisdiction: eu
Funding stream: European Regional Development Fund
Document URLhttps://www.molbiolcell.org/doi/10.1091/mbc.E20-05-0335
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Public note© 2021 Tolić and Pavin. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is avail able to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). Received: Oct 13, 2020. Revised: Nov 23, 2020. Accepted: Nov 24, 2020.
Created on2024-09-25 21:06:25