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doctoral thesis
Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale
Zagreb: University of Zagreb, Faculty of Science, 2014. urn:nbn:hr:217:881204
Trgo, Gorana
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Trgo, G. (2014). Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:881204

Trgo, Gorana. "Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale." Doctoral thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:881204

Trgo, Gorana. "Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale." Doctoral thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:881204

Trgo, G. (2014). 'Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:881204

Trgo G. Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2014 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:881204

G. Trgo, "Uloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:217:881204

Metadata
TitleUloga asimetričnog dimetilarginina (ADMA) u oksidativnom oštećenju gušterače tijekom akutne upale
Title (english)The role of asymmetric dimethylarginine (ADMA) response to oxidative damage in acute pancreatitis
AuthorGorana Trgo
MentorMaja Radman (mentor)
MBZ: 224802
MentorMarijana Vučić Lovrenčić (sumentor)
MBZ: 176744
Committee memberMarijana Popović Hadžija (član povjerenstva)
Committee memberZoran Tadić (član povjerenstva)
Committee memberMiljenko Solter (član povjerenstva)
MBZ: 74594
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2014, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
Akutna upala gušterače (pankreatitis) praćena je oksidativnim i dušičnim stresom, no doprinos ovih mehanizama oštećenju tkiva i disfunkciji endokrinog dijela gušterače slabo je istražen. U ovom radu istraživana je uloga asimetričnog dimetilarginina (ADMA), endogenog inhibitora sintetaze dušičnog oksida (NOS), u razvoju oksidativno-dušičnog stresa te regulaciji glikemije na kliničkom modelu akutnog pankreatitisa. Rezultati razotkrivaju akutni pankreatitis kao stanje značajnog poremećaja glukoregulacije, pojačanog oksidativnog i dušičnog stresa te poremećene ADMA-om posredovane regulacije sinteze dušičnog oksida (NO). Hiperglikemija i oksidativno-dušični stres identificirani su kao mogući značajni uzroci smanjene bioraspoloživosti ADMA-e tijekom akutnog pankreatitisa, a intolerancija glukoze mjesec dana nakon preboljelog pankreatitisa, koja je nađena u 64% ispitanika, u izravnoj je vezi s razinom ADMA-e tijekom akutne faze bolesti. Do sada nepoznata nedostatna inhibicija sinteze NO u akutnom pankreatitisu značajno pridonosi oštećenju endokrine gušterače i kasnijem razvoju šećerne bolesti.
Abstract (english)
Acute pancreatitis is characterised by the oxidative and nitrosative stress, but contribution of these mechanisms to the tissue damage and endocrine pancreas dysfunction has been insufficiently studied. This study aimed to investigate the role of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric-oxide synthetase (NOS), in development of oxidative-nitrosative stress and potentially disturbed glucoregulation in the clinical model of acute pancreatitis. Results reveal acute pancreatitis as a condition associated with a significant derrangement of glucoregulation and increased oxidative-nitrosative stress, as well as a disturbed ADMAregulated nitric oxide (NO) synthesis. Both hyperglycaemia and oxidative-nitrosative stress were identified as potential significant determinants of decreased ADMA-bioavailibility during acute pancreatitis, while glucose intolerance, found in 64% of patients 1 month after acute pancreatitis, was found to be directly associated with ADMA-level during acute phase of illness. Sofar unrecognized insufficient inhibition of NO-synthesis in acute pancreatitis contributes significantly to the endocrine pancreas damage and might be responsible for subsequent development of diabetes mellitus.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:881204
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-05-18 11:50:41