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master's thesis
O-tert-butiloksimi kinuklidina kao inhibitori butirilkolinesteraze
Zagreb: University of Zagreb, Faculty of Science, 2024. urn:nbn:hr:217:646405
Perić, Dora
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Perić, D. (2024). O-tert-butiloksimi kinuklidina kao inhibitori butirilkolinesteraze (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:646405

Perić, Dora. "O-tert-butiloksimi kinuklidina kao inhibitori butirilkolinesteraze." Master's thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:646405

Perić, Dora. "O-tert-butiloksimi kinuklidina kao inhibitori butirilkolinesteraze." Master's thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:646405

Perić, D. (2024). 'O-tert-butiloksimi kinuklidina kao inhibitori butirilkolinesteraze', Master's thesis, University of Zagreb, Faculty of Science, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:646405

Perić D. O-tert-butiloksimi kinuklidina kao inhibitori butirilkolinesteraze [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2024 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:646405

D. Perić, "O-tert-butiloksimi kinuklidina kao inhibitori butirilkolinesteraze", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:217:646405

Metadata
TitleO-tert-butiloksimi kinuklidina kao inhibitori butirilkolinesteraze
Title (english)Quinuclidine O-tert-butyl oximes as cholinesterase inhibitors
AuthorDora Perić
MentorInes Primožič (mentor)
Committee memberInes Primožič (predsjednik povjerenstva)
Committee memberJana Pisk (član povjerenstva)
Committee memberAdriana Kenđel (član povjerenstva)
Committee memberNikola Cindro (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2024-09-23, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U okviru ovoga rada pripravljen je O-tert-butilni eter kinuklidin-3-on-oksima reakcijom hidroklorida O-tert-butilhidroksilamina i kinuklidin-3-ona klasičnom organskom sintezom bez korištenja baze. Kvaternizacijom tercijarnoga dušikovog atoma kinuklidina metil-jodidom te različito supstituiranim benzil-bromidima (metilna ili nitro skupina te atomi halogena u meta ili para položaju) pripravljena je serija od dvanaest novih N-kvaternih derivata O-tert-butilnog etera kinuklidin-3-on-oksima. Struktura pripravljenih spojeva potvrđena je standardnim analitičkim postupcima koji uključuju infracrvenu spektroskopiju, 1D (1H, 13C) i 2D spektroskopske metode NMR te spektrometriju masa. Svim pripravljenim spojevima određen je inhibitorni potencijal prema enzimu butirilkolinesterazi (EC 3.1.1.8) iz konjskog seruma korištenjem Ellmanove metode za kolorimetrijsko određivanje aktivnosti acetilkolinesteraze.
Abstract (english)
In this work, O-tert-butyl ether of quinuclidin-3-one-oxime was prepared by the reaction of O- tert-butylhydroxylamine and quinuclidin-3-one hydrochloride by classic organic synthesis without using a base. By quaternization of the tertiary nitrogen atom of quinuclidine with methyl iodide and differently substituted benzyl bromides (methyl or nitro group and halogen atoms in the meta or para position), a series of twelve new N-quaternary derivatives of O-tert- butyl ether quinuclidin-3-one-oxime was prepared. The structure of the prepared compounds was confirmed by standard analytical procedures that include infrared spectroscopy, 1D (1H,13C) and 2D NMR spectroscopic methods and mass spectrometry. The inhibitory potential of all prepared compounds to the enzyme butyrylcholinesterase (EC 3.1.1.8) from horse serum was determined using the Ellman method for colorimetric determination of cholinesterase activity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:646405
ProjectNumber: IP-2022-10-9525
Title: Metom usmjerena sinteza inhibitora kolinesteraza podržana strojnim učenjem
Title: Target-guided synthesis of cholinesterase inhibitors supported by machine learning
Acronym: TargetCh
Leader: Ines Primožič
Jurisdiction: Croatia
Funder: Hrvatska zaklada za znanost
Funding stream: Research Projects
Study programmeTitle: Graduate university studies in chemistry; specializations in: Graduate university studies in chemistry
Course: Graduate university studies in chemistry
Study programme type: university
Study level: graduate
Academic / professional title: sveučilišni/a magistar/magistra kemije (sveučilišni/a magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-14 12:50:56