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master's thesis
Priprava i karakterizacija N-acilglicinamida
Zagreb: University of Zagreb, Faculty of Science, 2024. urn:nbn:hr:217:214697
Pavlinić, Matej
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Pavlinić, M. (2024). Priprava i karakterizacija N-acilglicinamida (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:214697

Pavlinić, Matej. "Priprava i karakterizacija N-acilglicinamida." Master's thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:214697

Pavlinić, Matej. "Priprava i karakterizacija N-acilglicinamida." Master's thesis, University of Zagreb, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:217:214697

Pavlinić, M. (2024). 'Priprava i karakterizacija N-acilglicinamida', Master's thesis, University of Zagreb, Faculty of Science, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:214697

Pavlinić M. Priprava i karakterizacija N-acilglicinamida [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2024 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:217:214697

M. Pavlinić, "Priprava i karakterizacija N-acilglicinamida", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:217:214697

Metadata
TitlePriprava i karakterizacija N-acilglicinamida
Title (english)Preparation and characterization of N-acyl glicine amides
AuthorMatej Pavlinić
MentorInes Primožič (mentor)
Committee memberInes Primožič (predsjednik povjerenstva)
Committee memberIvana Kekez (član povjerenstva)
Committee memberIvan Nemet (član povjerenstva)
Committee memberNikola Cindro (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2024-10-31, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U okviru ovog rada sintetizirana su dva N-acilglicinamida da bi se provjerila njihova inhibitorna svojstva prema enzimu butirilkolinesterazi: N-benzil-N-[2-(tosilmetilamino)-2-oksoetil]- piridin-2-karboksamid i N-benzil-N-[2-(tert-butilamino)-2-oksoetil]benzamid. Oba spoja sintetizirana su višekomponentnom Ugijevom reakcijom, koja se provodila uobičajenim sintetskim metodama, mikrovalovima potpomognutom sintezom i mehanokemijskom sintezom. Provedena je optimizacija uvjeta mikrovalovima potpomognute sinteze N-benzil-N-[2-(tert-butilamino)-2-oksoetil]benzamida. Pripravljenim spojevima određeno je talište te je provedena strukturna analiza korištenjem infracrvene spektroskopije, spektrometrije masa te 1D i 2D spektroskopije nuklearne magnetske rezonancije. Određen je i omjer cis i trans konformera pripravljenih N-acilglicinamida u otopini u protonskim i aprotonskim otapalima različite polarnosti.
Abstract (english)
In this diploma thesis two N-acylglicine amides were synthesized to obtain biactive compounds with inhibitory activity toward butyrylcholinesterase: N-benzyl-N-[2-(tosylmethyleamino)-2- oxoethyle]pyridyne-2-carboxyamide and N-benzyl-N-[2-(tert-buthyleamino)-2-oxoethyle]-benzamide. Both compounds were synthesized via Ugi multicomponent reaction. Reactions were performed using standard synthetic techniques, microwave assisted Ugi reaction as well as mechanochemical techniques. Conditions for the microwave assisted synthesis of N-benzyl-N-[2-(tert-buthyleamino)-2-oxoethyle]benzamide were optimized. The melting points of the prepared compounds were determined, and the structural analysis was performed using infrared spectroscopy, mass spectrometry and 1D and 2D nuclear magnetic resonance spectroscopy. Furthermore, the ratio of cis and trans conformers of prepared N-acylglycinamides in solution in protic and aprotic solvents of different polarity was also determined.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:214697
ProjectNumber: IP-2022-10-9525
Title: Metom usmjerena sinteza inhibitora kolinesteraza podržana strojnim učenjem
Title: Target-guided synthesis of cholinesterase inhibitors supported by machine learning
Acronym: TargetCh
Leader: Ines Primožič
Jurisdiction: Croatia
Funder: Hrvatska zaklada za znanost
Funding stream: Research Projects
Study programmeTitle: Graduate university studies in chemistry; specializations in: Graduate university studies in chemistry
Course: Graduate university studies in chemistry
Study programme type: university
Study level: graduate
Academic / professional title: sveučilišni/a magistar/magistra kemije (sveučilišni/a magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-11-14 13:11:26