prikaz prve stranice dokumenta Varijabilnost i heritabilnost glikozilacije imunoglobulina G
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doctoral thesis
Varijabilnost i heritabilnost glikozilacije imunoglobulina G
Zagreb: University of Zagreb, Faculty of Science, 2013. urn:nbn:hr:217:798397
Pučić Baković, Maja
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Pučić Baković, M. (2013). Varijabilnost i heritabilnost glikozilacije imunoglobulina G (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:798397

Pučić Baković, Maja. "Varijabilnost i heritabilnost glikozilacije imunoglobulina G." Doctoral thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:798397

Pučić Baković, Maja. "Varijabilnost i heritabilnost glikozilacije imunoglobulina G." Doctoral thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:798397

Pučić Baković, M. (2013). 'Varijabilnost i heritabilnost glikozilacije imunoglobulina G', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:798397

Pučić Baković M. Varijabilnost i heritabilnost glikozilacije imunoglobulina G [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2013 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:798397

M. Pučić Baković, "Varijabilnost i heritabilnost glikozilacije imunoglobulina G", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:217:798397

Metadata
TitleVarijabilnost i heritabilnost glikozilacije imunoglobulina G
Title (english)Variability and heritability of immunoglobulin G glycosylation
AuthorMaja Pučić Baković
MentorGordan Lauc (mentor)
Committee memberOlga Gornik (član povjerenstva)
Committee memberNada Oršolić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2013, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
Imunoglobulin G (IgG) je najzastupljeniji glikoprotein u ljudskoj plazmi i glavna efektorska molekula u humoralnom imunološkom odgovoru. Glikani su esencijalne strukturne komponente IgG antitijela pa čak i male promjene u sastavu glikana mogu promjeniti vezanje na Fc receptore i time značajno utjecati na efektorske funkcije IgG-a. Razvoj visoko protočnog pročišćavanja IgG-a iz plazme i optimizacija kromatografske metode visoke razlučivosti i osjetljivosti za analizu IgG glikana omogućili su prvu veliku studiju IgG N-glikoma u populaciji. Rezultati istraživanja na preko 2000 pojedinca otkrili su vrlo veliku varijabilnost dok je heritabilnost IgG glikana bila između 30 i 50%. Fc N-glikozilacija specifična za pojedine potklase IgG-a pokazala je značajnu spolnu i dobnu ovisnost. Najveće promjene u glikozilaciji opažene su kod žena koje prolaze kroz menopauzu. Smjer i intenzitet dobne ovisnosti promjena u glikozilaciji razlikovali su se između djece i odraslih. Cjelogenomskom asocijacijskom studijom IgG N-glikoma identificirano je devet genskih lokusa koji kontroliraju glikozilaciju IgG-a.
Abstract (english)
Immunoglobulin G (IgG) is the most abundant glycoprotein in the human plasma and a major effector molecule of the humoral immune response. Glycans are essential structural components of the IgG antibody and even small changes in glycan composition can have a profound influence on IgG effector function by modulating binding to the Fc receptors. A development of the high-throughput IgG purification from plasma and optimization of chromatographic method for IgG glycan analysis of high resolution and sensitivity enabled a first large-scale study of IgG N-glycome in a population. Results from over 2000 individuals revealed a very high variability while heritability of IgG glycans was generally between 30 and 50%. Subclass-specific IgGFc N-glycosylation analysis showed a significant age and sex-dependance. The most prominent changes in glycosylation in females were observed during menopausal age. Age-dependant changes in children differed from changes in adult population in both,direction and intensity. Genome-wide association study (GWAS) of the IgG N-glycome identified nine genetic loci that control IgG glycosylation.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:798397
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-05-19 11:43:11