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doctoral thesis
Genske, imunohistokemijske i morfološke značajke podgrupa difuznog B-velikostaničnog limfoma
Zagreb: University of Zagreb, Faculty of Science, 2013. urn:nbn:hr:217:276956
Škunca, Željka
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Škunca, Ž. (2013). Genske, imunohistokemijske i morfološke značajke podgrupa difuznog B-velikostaničnog limfoma (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:276956

Škunca, Željka. "Genske, imunohistokemijske i morfološke značajke podgrupa difuznog B-velikostaničnog limfoma." Doctoral thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:276956

Škunca, Željka. "Genske, imunohistokemijske i morfološke značajke podgrupa difuznog B-velikostaničnog limfoma." Doctoral thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:276956

Škunca, Ž. (2013). 'Genske, imunohistokemijske i morfološke značajke podgrupa difuznog B-velikostaničnog limfoma', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:276956

Škunca Ž. Genske, imunohistokemijske i morfološke značajke podgrupa difuznog B-velikostaničnog limfoma [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2013 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:276956

Ž. Škunca, "Genske, imunohistokemijske i morfološke značajke podgrupa difuznog B-velikostaničnog limfoma", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:217:276956

Metadata
TitleGenske, imunohistokemijske i morfološke značajke podgrupa difuznog B-velikostaničnog limfoma
Title (english)Genetic, immunohistochemical and morphological features of subgroups in diffuse large B-cell lymphoma
AuthorŽeljka Škunca
MentorAna Planinc-Peraica (mentor)
MBZ: 127470
Committee memberNada Lang (član povjerenstva)
MBZ: 54151
Committee memberAna Planinc-Peraica (član povjerenstva)
MBZ: 127470
Committee memberNada Oršolić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2013, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		575 - General genetics. General cytogenetics
Abstract
Difuzni B velikostanični limfom (engl. diffuse large B-cell lymphoma, DLBCL) je najučestaliji tip limfoma u bolesnika odrasle životne dobi. Zbog tako visoke zastupljenosti mi smo odlučili kod naših bolesnika ispitati prisutnost VEGFR2 i NF-ĸB, te ocijeniti njihov utjecaj na ishod kod bolesnika s DLBCL. Mi smo kod 99 bolesnika ispitali prisutnost tih tumorskih biljega, te abnormalnosti gena BCL2, BCL6 i c-MYC kod iste grupe bolesnika. Rezultati su pokazali da je kod imunohistokemijski određenih tumorskih biljega VEGFR2 i NF-κB koji se nalaze u citoplazmi i jezgri nađeno da samo NF-κB, koji je prisutan u citoplazmi ukazuje na značajno lošije preživljenje (p=0,037). Metodom FISH analize BCL2, BCL6 i c-MYC nije nađena značajna razlika u preživljenju među podgrupama DLBCL (p=0,714).
Abstract (english)
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in patient's elderly population. With such a high representation we decided our patients asses the pressence of VEGFR2 and NF-ĸB and assess their impact on outcome in patients with DLBCL. We investigated in 99 patients the presence of tumor markers and abnormalities of genes BCL2, BCL6 and c-MYC in the same group of patients. The results showed that in immunochistochemical markers of tumor VEGFR2 and NF-ĸB which are located in the cytoplasm and in the nucleus was found that only NF-ĸB, which is present in the cytoplasm indicates a singnificantly worse survival (p=0.037). FISH analaysis of BCL2, BCL6 and c-MYC was not found significant differences in survival among subgroups of DLBCL (p=0.714).
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:276956
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-05-19 12:14:17