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doctoral thesis
Uloga polimorfizama kandidatskih gena za kardiovaskularne bolesti u dugovječnosti: antropološki pristup
Zagreb: University of Zagreb, Faculty of Science, 2013. urn:nbn:hr:217:413621
Zajc Petranović, Matea
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Zajc Petranović, M. (2013). Uloga polimorfizama kandidatskih gena za kardiovaskularne bolesti u dugovječnosti: antropološki pristup (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:413621

Zajc Petranović, Matea. "Uloga polimorfizama kandidatskih gena za kardiovaskularne bolesti u dugovječnosti: antropološki pristup." Doctoral thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:413621

Zajc Petranović, Matea. "Uloga polimorfizama kandidatskih gena za kardiovaskularne bolesti u dugovječnosti: antropološki pristup." Doctoral thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:413621

Zajc Petranović, M. (2013). 'Uloga polimorfizama kandidatskih gena za kardiovaskularne bolesti u dugovječnosti: antropološki pristup', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 30 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:413621

Zajc Petranović M. Uloga polimorfizama kandidatskih gena za kardiovaskularne bolesti u dugovječnosti: antropološki pristup [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2013 [cited 2024 December 30] Available at: https://urn.nsk.hr/urn:nbn:hr:217:413621

M. Zajc Petranović, "Uloga polimorfizama kandidatskih gena za kardiovaskularne bolesti u dugovječnosti: antropološki pristup", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:217:413621

Metadata
TitleUloga polimorfizama kandidatskih gena za kardiovaskularne bolesti u dugovječnosti: antropološki pristup
Title (english)The role of polymorphisms in candidate genes for cardiovascular diseases in longevity: anthropological approach
AuthorMatea Zajc Petranović
MentorTatjana Škarić-Jurić (mentor)
Committee memberKrunoslav Brčić-Kostić (član povjerenstva)
Committee memberAna Galov (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2013, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		575 - General genetics. General cytogenetics
Abstract
Kardiovaskularne su bolesti (KVB) glavni uzročnik pobola i smrtnosti diljem svijeta, a podložnost razvoju bolesti povećava interakcija okolišnih, biokemijskih i genetičkih čimbenika rizika. Kako dugovječnost nije ništa drugo nego izbjegavanje smrtnog ishoda, provedena je analiza povezanosti četiriju polimorfizama kandidatskih gena za KVB (ACE, APOE, eNOS, MTHFR) s negenetičkim čimbenicima rizika u uzorku osoba starijih od 80 godina. Logistička regresija je pokazala da kombinacija genotipova ACE-DD i MTHFR-CC smanjuje šansu doživljenja duboke starosti (≥90 g.) prema modelu koji objašnjava čak 27,5% varijance. Meta-analiza učestalosti javljanja ispitivanih alela kod opće populacije u odnosu na osobe starije od 80 godina, koja je provedena korištenjem literaturnih podataka za Europske populacije, je pokazala da su D alel ACE gena i E2 alel APOE gena češći su kod osoba starih 80+ godina, dok je E4 alel češći kod opće populacije. Istraživanje je ukazalo na prisutnost selektivnog mortaliteta kod nosioca E4 alela APOE gena kao i na zavisne od dobi, pleiotropne učinke ACE I/D polimorfizma.
Abstract (english)
Cardiovascular diseases (CVDs) are the major cause of morbidity and mortality worldwide, and the susceptibility to developing CVD is increased by the interaction of several environmental, biochemical and genetic risk factors. Since longevity is nothing but avoiding death, the association analysis of polymorphisms in four candidate genes for CVDs (ACE, APOE, eNOS, MTHFR) with non-genetic risk factors was performed in a sample od people aged 80 years and over. Logistic regression analysis showed that the combination of ACE-DD and MTHFR-CC genotypes reduced the chance of survival into nonagenarian age, in a model explaining as much as 27.5% of the variance. The meta-analysis, carried out using published data for the European populations, tested the frequency of the investigated alleles between general and 80+ population, and showed that ACE D allele and APOE E2 allele were more common in elderlies, while E4 allele was more common in general population. This research indicated the existence of selective mortality in APOE E4-carriers, as well as the age- dependent, pleiotropic effects of the ACE I/D polymorphism.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:413621
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2017-05-22 07:38:35