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master's thesis
Priprava heterocikličih alfa-D-manopiranozida kao potencijalnih inhibitora hemaglutinacije. Dulong-Petit i nastava kemije.
Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:733348
Dugandžija, Dario
University of Zagreb
Faculty of Science
Department of Biology
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Dugandžija, D. (2017). Priprava heterocikličih alfa-D-manopiranozida kao potencijalnih inhibitora hemaglutinacije. Dulong-Petit i nastava kemije. (Master's thesis). Zagreb: University of Zagreb, Faculty of Science; Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:733348

Dugandžija, Dario. "Priprava heterocikličih alfa-D-manopiranozida kao potencijalnih inhibitora hemaglutinacije. Dulong-Petit i nastava kemije.." Master's thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:733348

Dugandžija, Dario. "Priprava heterocikličih alfa-D-manopiranozida kao potencijalnih inhibitora hemaglutinacije. Dulong-Petit i nastava kemije.." Master's thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:733348

Dugandžija, D. (2017). 'Priprava heterocikličih alfa-D-manopiranozida kao potencijalnih inhibitora hemaglutinacije. Dulong-Petit i nastava kemije.', Master's thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:733348

Dugandžija D. Priprava heterocikličih alfa-D-manopiranozida kao potencijalnih inhibitora hemaglutinacije. Dulong-Petit i nastava kemije. [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:733348

D. Dugandžija, "Priprava heterocikličih alfa-D-manopiranozida kao potencijalnih inhibitora hemaglutinacije. Dulong-Petit i nastava kemije.", Master's thesis, University of Zagreb, Faculty of Science, Zagreb; University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:733348

Metadata
TitlePriprava heterocikličih alfa-D-manopiranozida kao potencijalnih inhibitora hemaglutinacije. Dulong-Petit i nastava kemije.
Title (english)Synthesis of heterocyclic alpha-D-mannopyranosides as potential hemagglutation inhibitors. Dulog-Petit and chemistry teaching.
AuthorDario Dugandžija
MentorSrđanka Tomić-Pisarović (mentor)
MentorNenad Judaš (mentor)
Committee memberSrđanka Tomić-Pisarović (predsjednik povjerenstva)
Committee memberNenad Judaš (član povjerenstva)
Committee memberMirjana Pavlica (član povjerenstva)
Committee memberBožena Mitić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2017-02-02, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
U okviru ovog diplomskog rada opisana je priprava i karakterizacija novih heterocikličkih α-D-manokonjugata kao potencijalnih inhibitora hemaglutinacije uropatogene bakterije E.coli. Kao početni spoj uzeta je α-D-manoza. U četiri koraka, koji uključuju acetiliranje šećera, pripravu glikozida, reakciju s heterocikličkim spojevima te uklanjanje acetatne zaštite, dobiveno je 7 novih spojeva od kojih su 3 korišteni kao mogući inhibitori hemaglutinacije na eritrocitima iz krvi zamorčića. Strukturna svojstva i analiza pripravljenih spojeva provedeni su klasičnim analitičkim spektroskopskim metodama (IR, 1H i 13C NMR) te spektrometrijom masa (MS). Čistoća pripremljenih spojeva te optička čistoća utvrđene su kromatografijom (TSK) i mjerenjem optičkog skretanja. U metodičkom dijelu rada prikazan je prijedlog nastavnog sata pod nazivom „Dulong-Petit i nastava kemije“ u kojem je navedena i opisana priprema sata primjerena za učenike prvog razreda srednje škole za koji je detaljno razrađen radni listić za učenike.
Abstract (english)
In this thesis, synthesis and characterisation of novel heterocyclic α-D-mannoconjugates which can serve as potential hemagglutination inhibitors of uropathogenic E. coli are described. α-D-Mannose was used as a starting compound. Sugar acetylation was the first step followed by O-glycosidation, the reaction with heterocyclic compounds and removal of acetyl groups. Seven (7) novel compounds were prepared in four steps. Three (3) of them were tested as potential hemagglutination inhibitiors of red blood cells from guinea pig. Structure and analysis of all obtained compounds were determined using common analytical methods that included IR, 1H and 13C NMR spectroscopies and MS. The purity of prepared compounds was also determinted by thin layer cromatography (TLC) and optical rotation measurements. In the second part of this thesis one of the possible modern approaches in teaching for high school students is presented. The topic titled „Dulong-Petit and chemistry teaching“, with special emphasis on the use of experiments in teaching chemistry.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:733348
Study programmeTitle: Integrated undergraduate and graduate university study of Biology and Chemistry Education; specializations in: Integrated undergraduate and graduate university study of Biology and Chemistry Education
Course: Integrated undergraduate and graduate university study of Biology and Chemistry Education
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra edukacije biologije i kemije (magistar/magistra edukacije biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-05-22 10:18:21