prikaz prve stranice dokumenta Praćenje priprave omeprazola primjenom spregnutog sustava LC-SPE/NMR. NMR i srednjoškolski nastavni program iz kemije.
Access restricted to students and staff of home institution
master's thesis
Praćenje priprave omeprazola primjenom spregnutog sustava LC-SPE/NMR. NMR i srednjoškolski nastavni program iz kemije.
Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:799149
Magdalenić, Marta
University of Zagreb
Faculty of Science
Department of Biology
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Magdalenić, M. (2017). Praćenje priprave omeprazola primjenom spregnutog sustava LC-SPE/NMR. NMR i srednjoškolski nastavni program iz kemije. (Master's thesis). Zagreb: University of Zagreb, Faculty of Science; Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:799149

Magdalenić, Marta. "Praćenje priprave omeprazola primjenom spregnutog sustava LC-SPE/NMR. NMR i srednjoškolski nastavni program iz kemije.." Master's thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:799149

Magdalenić, Marta. "Praćenje priprave omeprazola primjenom spregnutog sustava LC-SPE/NMR. NMR i srednjoškolski nastavni program iz kemije.." Master's thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:799149

Magdalenić, M. (2017). 'Praćenje priprave omeprazola primjenom spregnutog sustava LC-SPE/NMR. NMR i srednjoškolski nastavni program iz kemije.', Master's thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:799149

Magdalenić M. Praćenje priprave omeprazola primjenom spregnutog sustava LC-SPE/NMR. NMR i srednjoškolski nastavni program iz kemije. [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:799149

M. Magdalenić, "Praćenje priprave omeprazola primjenom spregnutog sustava LC-SPE/NMR. NMR i srednjoškolski nastavni program iz kemije.", Master's thesis, University of Zagreb, Faculty of Science, Zagreb; University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:799149

Metadata
TitlePraćenje priprave omeprazola primjenom spregnutog sustava LC-SPE/NMR. NMR i srednjoškolski nastavni program iz kemije.
Title (english)Monitoring of omeprazole synthesis by hyphenated LC-SPE/NMR system. NMR and high-school chemical syllabus.
AuthorMarta Magdalenić
MentorPredrag Novak (mentor)
MentorNenad Judaš (mentor)
Committee memberPredrag Novak (predsjednik povjerenstva)
Committee memberNenad Judaš (član povjerenstva)
Committee memberPerica Mustafić (član povjerenstva)
Committee memberBožena Mitić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2017-02-24, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
U ovom diplomskom radu opisano je praćenje reakcije oksidacije omeprazol sulfida, poslijednjeg koraka prilikom sinteze omeprazola, pomoću spregnutog sustava tekućinska kromatografija-ekstrakcija na čvrstoj fazi-nuklearna magnetska rezonancija (LC-SPE/NMR). Omeprazol je lijek koji se koristi za liječenje bolesti uzrokovane pretjeranim lučenjem želučane kiseline, a djeluje tako da regulira enzimski sustav odgovoran za njezino izlučivanje. U radu su optimirani uvjeti tekućinskokromatografskog odjeljivanja, skladištenja uzoraka na sustavu SPE te snimanja spektara NMR. Uspoređene su metodologije on-line i off-line za praćenje sinteze omeprazola i identifikaciju produkata, nusprodukata i nečistoća. U okviru metodičkog dijela rada prikazan je prijedlog nastavnog sata pod nazivom „Nuklearna magnetska rezonancija“ u kojem je opisana priprema sata namijenjena učenicima četvrtog razreda srednje škole te je detaljno razrađen radni listić za učenike.
Abstract (english)
This thesis describes monitoring the oxidation reaction of omeprazole sulfide, which is the last step in omeprazole synthesis by hyphenated liquid chromatography-solid phase extraction-nuclear magnetic resonance methodology (LC-SPE/NMR). Drug Omeprazole blocks enzyme system responsible for the secretion of gastric acid. That is the reason why it is used for the treatment of diseases caused by hypersecretion of gastric acid. Conditions of liquid chromatography separation, trapping on SPE cartridges and recording of NMR spectra were optimized. On-line and off-line methodologies for monitoring the omeprazole synthesis and identification of products, byproducts and impurities were disscused. In the second part of this thesis one of the possible modern approaches in teaching chemistry for high school students have been elaborated. The title of the topic is „Nuclear magnetic resonance“ and a worksheet for students is enclosed.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:799149
Study programmeTitle: Integrated undergraduate and graduate university study of Biology and Chemistry Education; specializations in: Integrated undergraduate and graduate university study of Biology and Chemistry Education
Course: Integrated undergraduate and graduate university study of Biology and Chemistry Education
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra edukacije biologije i kemije (magistar/magistra edukacije biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-05-22 10:42:11