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master's thesis
Studij interakcija amino-supstituiranih tetracikličkih imidazo [4,5-B] piridina s cinkovim i bakrovim(II) ionima pomoću spektrometrije masa
Zagreb: University of Zagreb, Faculty of Science, 2025. urn:nbn:hr:217:784460
Martinac, Ingrid Ana
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Martinac, I. A. (2025). Studij interakcija amino-supstituiranih tetracikličkih imidazo [4,5-B] piridina s cinkovim i bakrovim(II) ionima pomoću spektrometrije masa (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:784460

Martinac, Ingrid Ana. "Studij interakcija amino-supstituiranih tetracikličkih imidazo [4,5-B] piridina s cinkovim i bakrovim(II) ionima pomoću spektrometrije masa." Master's thesis, University of Zagreb, Faculty of Science, 2025. https://urn.nsk.hr/urn:nbn:hr:217:784460

Martinac, Ingrid Ana. "Studij interakcija amino-supstituiranih tetracikličkih imidazo [4,5-B] piridina s cinkovim i bakrovim(II) ionima pomoću spektrometrije masa." Master's thesis, University of Zagreb, Faculty of Science, 2025. https://urn.nsk.hr/urn:nbn:hr:217:784460

Martinac, I. A. (2025). 'Studij interakcija amino-supstituiranih tetracikličkih imidazo [4,5-B] piridina s cinkovim i bakrovim(II) ionima pomoću spektrometrije masa', Master's thesis, University of Zagreb, Faculty of Science, accessed 28 March 2025, https://urn.nsk.hr/urn:nbn:hr:217:784460

Martinac IA. Studij interakcija amino-supstituiranih tetracikličkih imidazo [4,5-B] piridina s cinkovim i bakrovim(II) ionima pomoću spektrometrije masa [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2025 [cited 2025 March 28] Available at: https://urn.nsk.hr/urn:nbn:hr:217:784460

I. A. Martinac, "Studij interakcija amino-supstituiranih tetracikličkih imidazo [4,5-B] piridina s cinkovim i bakrovim(II) ionima pomoću spektrometrije masa", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2025. Available at: https://urn.nsk.hr/urn:nbn:hr:217:784460

Metadata
TitleStudij interakcija amino-supstituiranih tetracikličkih imidazo [4,5-B] piridina s cinkovim i bakrovim(II) ionima pomoću spektrometrije masa
Title (english)Study of interactions of amino-substututed tetracyclic imidazo [4,5-b] pyridines with zinc and copper(II) ions using mass spectrometry
AuthorIngrid Ana Martinac
MentorRenata Kobetić (mentor)
Committee memberIva Juranović Cindrić (predsjednik povjerenstva)
Committee memberJana Pisk (član povjerenstva)
Committee memberĐani Škalamera (član povjerenstva)
Committee memberIvan Nemet (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2025-01-29, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Nedavno je sintetiziran novi niz tetracikličkih derivata imidazo[4,5-b]piridina kao potencijalnih antiproliferativnih sredstava. Na njihovu antiproliferativnu aktivnost protiv ljudskih stanica raka utjecalo je uvođenje odabranih amino bočnih lanaca na različite položaje na tetracikličkom skeletu, a posebno na položaj atoma dušika u jezgri piridina. Nekoliko spojeva pokazalo je izražene citostatske učinke u submikromolarnom području, posebice na stanice raka HCT116 i MCF-7. Izabrano je 4... More novosintetiziranih spojeva za analizu nekovalentnih interakcija s metalnim ionima (cinkov i bakrov(II) ion) pomoću spektrometrije masa uz ionizaciju elektroraspršenjem. Na temelju dobivenih spektara predložene su strukture kompleksa izabranih spojeva s bakrovim(II) ionom i predložene su strukture kompleksa izabranih spojeva sa cinkovim(II) ionom. Rezultati ovog diplomskog rada mogli bi poslužiti za procjenu nekovalentnih interakcija izabranih spojeva s metalnim ionima (cinkov i bakrov(II) ion) u budućoj primjeni predmetnih spojeva u studijama djelovanja u stanici, ali i kao potencijalni novi spojevi za daljnja istraživanja i primjenu u medicini. Less
Abstract (english)
A new series of tetracyclic imidazo[4,5-b]pyridine derivatives have been synthesized as potential antiproliferative agents. Their antiproliferative activity against human cancer cells was influenced by the introduction of selected amino side chains to different positions on the tetracyclic skeleton, especially to the position of the nitrogen atom in the pyridine core. Several compounds showed pronounced cytostatic effects in the submicromolar range, especially on HCT116 and MCF-7... More cancer cells. 4 newly synthesized compounds were selected for analysis of non covalent interactions with metal ions (zinc and copper(II) ions) using mass spectrometry with electrospray ionization. The structures of the complexes of the selected compounds with copper(II) ion and stuctures of the complexes of the selected compounds with zinc(II) ion were proposed. The results of this thesis could be used to evaluate the non-covalent interactions of selected compounds with metal ions (zinc and copper(II) ions) for the eventual application of the compounds in question in studies of their action in the cell, but also as potential new compounds for further research and application in medicine. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:784460
ProjectNumber: IP-2018-01-4694
Title: Molekularno prepoznavanje DNA:RNA hibridnih i višelančanih struktura u bioanalitičkim i in vitro sustavima
Title: Molecular recognition of DNA:RNA hybrid and multistranded structures in bioanalytical and in vitro systems
Acronym: DNARNAHyB-MolBio
Leader: Marijana Radić Stojković
Jurisdiction: Croatia
Funder: Hrvatska zaklada za znanost
Funding stream: Research Projects
ProjectNumber: IP-2018-01-4379
Title: Istraživanje antioksidativnog djelovanja benzazolskog skeleta u dizajnu novih antitumorskih agensa
Acronym: AntioxPot
Leader: Marijana Hranjec
Jurisdiction: Croatia
Funder: Hrvatska zaklada za znanost
Funding stream: Research Projects
Study programmeTitle: Graduate university studies in chemistry; specializations in: Graduate university studies in chemistry
Course: Graduate university studies in chemistry
Study programme type: university
Study level: graduate
Academic / professional title: sveučilišni/a magistar/magistra kemije (sveučilišni/a magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2025-02-04 14:05:23
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