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doctoral thesis
Utjecaj »gena dugovječnosti« na biološku dob u osoba duboke starosti
Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:566850
Krajačić, Petra
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Krajačić, P. (2017). Utjecaj »gena dugovječnosti« na biološku dob u osoba duboke starosti (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:566850

Krajačić, Petra. "Utjecaj »gena dugovječnosti« na biološku dob u osoba duboke starosti." Doctoral thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:566850

Krajačić, Petra. "Utjecaj »gena dugovječnosti« na biološku dob u osoba duboke starosti." Doctoral thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:566850

Krajačić, P. (2017). 'Utjecaj »gena dugovječnosti« na biološku dob u osoba duboke starosti', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 28 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:566850

Krajačić P. Utjecaj »gena dugovječnosti« na biološku dob u osoba duboke starosti [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2024 December 28] Available at: https://urn.nsk.hr/urn:nbn:hr:217:566850

P. Krajačić, "Utjecaj »gena dugovječnosti« na biološku dob u osoba duboke starosti", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:566850

Metadata
TitleUtjecaj »gena dugovječnosti« na biološku dob u osoba duboke starosti
Title (english)Influence of »longevity genes« on the biological age in persons of very old age
AuthorPetra Krajačić
MentorTatjana Škarić-Jurić (mentor)
Committee memberIvica Rubelj (član povjerenstva)
Committee memberAna Galov (član povjerenstva)
Committee memberNina Smolej Narančić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2017, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		57 - Biological sciences. Physical anthropology. Biodiversity
Abstract
U okviru ove doktorske disertacije provedena je asocijacijska studija funkcionalno najvažnijih polimorfizama četiri kandidatska «gena dugovječnosti» (TP53, IL-6, TNF-α i SIRT1) sa širokim spektrom varijabli (anketnih i biometrijskih) povezanih sa zdravljem u uzorku od 344 osobe duboke starosti (85 i više godina). Univarijatne analize istaknule su spolno specifičnu strukturu povezanosti varijabli zdravstvenog statusa s ispitivanim polimorfizmima. Kod oba spola, faktorska analiza izlučila je faktor „općeg zdravlja“ koji je uz a priori konstruirane aditivne skale zdravstvenih rizika korišten kao varijabla biološke dobi. Među pet ispitivanih polimorfizama samo je rs1800795 polimorfizam IL-6 gena pokazao značajnu povezanost s kompozitnim varijablama biološke dobi kod muškaraca te time svoj mogući pleiotropni utjecaj na proces starenja kod ovog spola. S obzirom na dostupnost literaturnih podataka iz različitih populacija, međugeneracijska meta-analiza provedena je za dva polimorfizma (u TP53 i IL-6) te je indicirala mogući utjecaj Arg72Pro polimorfizma TP53 gena na dugovječnost.
Abstract (english)
In this dissertation an association study of functionally most important polymorphisms in four candidate longevity genes (TP53, IL-6, TNF-α, SIRT1) was conducted with a wide spectrum of variables associated with health status in 344 people of very old age (85+ yrs). Univariate analysis highlighted gender specific association of health status variables with investigated polymorphisms. In both genders factor analysis extracted the "general health" factor which was used as a biological age variable together with a priori constructed additive health risks scale. Among five investigated polymorphisms only the rs1800795 polymorphysm of IL-6 gene showed significant association with composite variables of biological age in male population, and thereby its pleitropic effect on the process of ageing in male sex. Considering availability of literature data for different populations, intergenerational meta-analysis was conducted for two polymorphisms (in TP53, IL-6) and indicated the possible effect of Arg72Pro polymorphism of TP53 gene on longevity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:566850
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-06-06 12:53:05