prikaz prve stranice dokumenta Utjecaj genotipova krvnih grupa ABO i inhibitora aktivatora plazminogena na ventilacijsku funkciju u astmi
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doctoral thesis
Utjecaj genotipova krvnih grupa ABO i inhibitora aktivatora plazminogena na ventilacijsku funkciju u astmi
Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:675392
Lampalo, Marina
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Lampalo, M. (2017). Utjecaj genotipova krvnih grupa ABO i inhibitora aktivatora plazminogena na ventilacijsku funkciju u astmi (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:675392

Lampalo, Marina. "Utjecaj genotipova krvnih grupa ABO i inhibitora aktivatora plazminogena na ventilacijsku funkciju u astmi." Doctoral thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:675392

Lampalo, Marina. "Utjecaj genotipova krvnih grupa ABO i inhibitora aktivatora plazminogena na ventilacijsku funkciju u astmi." Doctoral thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:675392

Lampalo, M. (2017). 'Utjecaj genotipova krvnih grupa ABO i inhibitora aktivatora plazminogena na ventilacijsku funkciju u astmi', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:675392

Lampalo M. Utjecaj genotipova krvnih grupa ABO i inhibitora aktivatora plazminogena na ventilacijsku funkciju u astmi [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:675392

M. Lampalo, "Utjecaj genotipova krvnih grupa ABO i inhibitora aktivatora plazminogena na ventilacijsku funkciju u astmi", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:675392

Metadata
TitleUtjecaj genotipova krvnih grupa ABO i inhibitora aktivatora plazminogena na ventilacijsku funkciju u astmi
Title (english)The effect of ABO blood genotypes and tissue plasminogen activator inhibitor on lung ventilation in asthma
AuthorMarina Lampalo
MentorIrena Jukić (mentor)
MBZ: 341464
Committee memberNada Oršolić (predsjednik povjerenstva)
Committee memberSanja Popović-Grle (član povjerenstva)
MBZ: 153353
Committee memberJasna Bingulac-Popović (član povjerenstva)
MBZ: 177071
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2017, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		575 - General genetics. General cytogenetics
Abstract
Inhibitor plazminogen aktivatora-1(PAI-1) je glikoprotein koji regulira fibrinolitički sustav. U plazmi osoba nositelja genotipa 4G/4G nalazi se 25% viša koncentracija PAI-1 u odnosu na osobe s genotipom 5G/5G.U provedenoj studiji utvrdili smo povezanost između PAI-1 -675 4G/5G polimorfizma i razvoja alergijskog rinitisa kod asmatičara u hrvatskoj populaciji. U studiji je sudjelovalo 149 pacijenata s dijagnozom astme i 153 zdrava subjekta kao kontrolne skupine. Utvrdili smo značajno višu učestalost 4G/4G genotipa kod asmatičara s alergijskim rinitisom u usporedbi s onim pacijentima bez alergijskog rinitisa. Pokazalo se kako je prisutnost 4G/4G genotipa rizični faktor za alergijski rinitis kod pacijenata s astmom. Ovo pokazuje da je prisutnost barem jednog 4G alela važni rizični faktor za alergijski rinitis kod asmatičara. Usporedba frekvencija ABO genotipova između skupine pacijenata i kontrole nije pokazala statistički značajnu povezanost određenih ABO genotipova s razvojem astme.
Abstract (english)
Plasminogen activator inhibitor-1 (PAI-1) is a glycoprotein which regulates fibrinolytic system. In plasma of 4G/4G genotype carriers there is 25% higher level of PAI-1, when compared to 5G/5G genotype carriers. In conducted study we confirmed connection between PAI-1-675 4G/5G polymorphism and development of allergic rhinitis in patients with asthma in Croatian population. Study included 149 adult patients with diagnosis of asthma and 153 healthy individuals of the control group. We confirmed significantly higher frequency of 4G/4G genotype in patients with asthma and allergic rhinitis when compared to the patients with asthma, but without allergic rhinitis. Presence of 4G/4G genotype showed to be a risk factor for allergic rhinitis in patients with asthma. This shows that presence of at least one 4G allele is an important risk factor for allergic rhinitis in patients with asthma. Comparison of frequencies of ABO genotypes between the group of patients with asthma and allergic rhinitis and the control group showed no statistically significant connection between certain ABO genotypes and development of asthma.Furthermore, statistical analysis of connection between ABO genotypes and asthma in patients with asthma and allergic rhinitis in comparison with that connection in control group showed that there is no statistically significant connection between carriers of certain ABO genotype carriers and development of asthma.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:675392
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2018-07-06
Terms of useLicence In copyright icon
Created on2017-07-19 09:07:46