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doctoral thesis
Hidrazino - derivati aminokiselina u sintezi peptidomimetika
Zagreb: University of Zagreb, Faculty of Science, 2016. urn:nbn:hr:217:472032
Suć, Josipa
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Suć, J. (2016). Hidrazino - derivati aminokiselina u sintezi peptidomimetika (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:472032

Suć, Josipa. "Hidrazino - derivati aminokiselina u sintezi peptidomimetika." Doctoral thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:472032

Suć, Josipa. "Hidrazino - derivati aminokiselina u sintezi peptidomimetika." Doctoral thesis, University of Zagreb, Faculty of Science, 2016. https://urn.nsk.hr/urn:nbn:hr:217:472032

Suć, J. (2016). 'Hidrazino - derivati aminokiselina u sintezi peptidomimetika', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:472032

Suć J. Hidrazino - derivati aminokiselina u sintezi peptidomimetika [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2016 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:217:472032

J. Suć, "Hidrazino - derivati aminokiselina u sintezi peptidomimetika", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:217:472032

Metadata
TitleHidrazino - derivati aminokiselina u sintezi peptidomimetika
Title (english)Synthesis of peptidomimetics comprising hydrazino - derivatives of amino acides
AuthorJosipa Suć
MentorIvanka Jerić (mentor)
Committee memberInes Primožič (predsjednik povjerenstva)
Committee memberIvanka Jerić (član povjerenstva)
Committee memberZdenko Hameršak (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2016-07-07, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Universal decimal classification
(UDC)		54 - Chemistry. Crystallography. Mineralogy
Abstract
Peptidi i proteini imaju ključnu ulogu u nizu bioloških i fizioloških procesa; međutim, njihova primjena kao terapeutika je ograničena slabom stabilnošću i biodostupnošću. Stoga je razvoj peptidomimetika, spojeva koji oponašaju strukturu i/ili funkciju proteina od velikog značaja za akademsku zajednicu i farmaceutsku industriju. Cilj istraživanja predloženih u okviru doktorske disertacije je priprava peptidomimetika korištenjem hidrazino-derivata -aminokiselina. Istraživanja će uključivati: razvoj metodologije za pripravu optički čistih hidrazino-derivata -aminokiselina te razvoj metodologije za pripravu hidrazino-peptidomimetika postupnom sintezom u otopini i primjenom u višekomponentnim reakcijama. Istraživanja bi trebala rezultirati optimiranim uvjetima priprave hidrazino-derivata -aminokiselina i hidrazino-peptidomimetika te potpuno novom skupinom peptidomimetika s ugrađenom hidrazino-jedinicom.
Abstract (english)
Peptides and proteins have a crucial role in a number of biological and physiological processes; however, their use as therapeutics is limited by poor stability and bioavailability. Therefore, the development of peptidomimetics, compounds that mimic structure and/or function of proteins is of great importance for the academic community and the pharmaceutical industry. The objective of the research proposed in this doctoral thesis is the preparation of peptidomimetics using hydrazino derivatives of -amino acids. Therefore, studies include: development of methodologies for the preparation of optically pure hydrazino derivatives of -amino acids; development of methodology for the preparation of hydrazino peptidomimetics by stepwise synthesis in solution and by multicomponent reactions. Expected results are: optimized conditions for the preparation of hydrazino derivatives of -amino acids and hydrazino peptidomimetics and a new class of peptidomimetics comprising hydrazino moiety. Item Type: Thesis (Doctoral thesis)
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:472032
Study programmeTitle: Doctoral study in chemistry
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija (doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija)
Type of resourceText
Extent191 str. ; 30 cm
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-02-06 11:32:27