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master's thesis
Polimorfizam gena B4GALNT1 i ST3GAL5 u karcinomu vrata maternice
Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:719115
Selak, Nikica
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Selak, N. (2017). Polimorfizam gena B4GALNT1 i ST3GAL5 u karcinomu vrata maternice (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:719115

Selak, Nikica. "Polimorfizam gena B4GALNT1 i ST3GAL5 u karcinomu vrata maternice." Master's thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:719115

Selak, Nikica. "Polimorfizam gena B4GALNT1 i ST3GAL5 u karcinomu vrata maternice." Master's thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:719115

Selak, N. (2017). 'Polimorfizam gena B4GALNT1 i ST3GAL5 u karcinomu vrata maternice', Master's thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:719115

Selak N. Polimorfizam gena B4GALNT1 i ST3GAL5 u karcinomu vrata maternice [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:719115

N. Selak, "Polimorfizam gena B4GALNT1 i ST3GAL5 u karcinomu vrata maternice", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:719115

Metadata
TitlePolimorfizam gena B4GALNT1 i ST3GAL5 u karcinomu vrata maternice
Title (english)B4GALNT1 and ST3GAL5 gene polymorphisms in cervical cancer
AuthorNikica Selak
MentorJasenka Wagner (mentor)
MentorPetra Korać (mentor)
Committee memberPetra Korać (predsjednik povjerenstva)
Committee memberAna Galov (član povjerenstva)
Committee memberJasna Lajtner (član povjerenstva)
Committee memberPetar Kružić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2017-07-18, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
U ovome radu istražen je mogući utjecaj polimorfizama gena B4GALNT1 (rs715930) i ST3GAL5 (rs1138484) na pojavu i razvoj karcinoma vrata maternice. Prema podatcima Svjetske zdravstvene organizacije, karcinom vrata maternice, koji je uzrokovan ljudskim papilloma virusom (HPV), drugi je po učestalosti karcinom u žena u svijetu. Enzimi B4GALNT1 i ST3GAL5 sudjeluju u biosintezi složenih gangliozida, koji su bitni za biološku funkciju lipidnih splavi. Lipidne splavi imaju bitnu ulogu u aktivaciji T-limfocita koji sudjeluju u imunološkom odgovoru na infekciju HPV-om. Polimorfizmi navedenih gena analizirani su kod 80 ispitanica s dijagnozom karcinoma vrata maternice i 82 žene bez te dijagnoze i bez dokazane infekcije HPV-om. Nije pronađena statistički značajna razlika u učestalosti pojedinih alela i genotipova između kontrolne skupine i skupine ispitanica s dijagnozom karcinoma vrata maternice za oba polimorfizma.
Abstract (english)
This thesis examines the possible effects of single-nucleotide polymorphisms (SNPs) of the B4GALNT1 gene (rs715930) and ST3GAL5 gene (rs1138484) in cervical cancer oncogenesis. According to data provided by the World Health Organization, cervical cancer, caused by the human papillomavirus (HPV), is the second most common cancer in women worldwide. B4GALNT1 and ST3GAL5 enzymes are involved in the biosynthesis of complex gangliosides that play an important role in the biological function of lipid rafts. Lipid rafts have a key role in the activation of T-lymphocytes during the immune response to HPV infection. Analysis of B4GALNT1 and ST3GAL5 polymorphisms was done in samples from 80 patients diagnosed with cervical carcinoma and 82 women in the control group (patients without cervical carcinoma diagnosis and HPV infection). There was no significant difference in the distribution of alleles and genotypes between the case and control groups for both SNPs.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:719115
Study programmeTitle: Experimental Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra eksperimentalne biologije (magistar/magistra eksperimentalne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-09-07 09:53:38