prikaz prve stranice dokumenta Mehanizmi bakterija kojim se stanice domaćina mogu prevesti u tumorske
  Download
PDF 632.84 KB
undergraduate thesis
Mehanizmi bakterija kojim se stanice domaćina mogu prevesti u tumorske
Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:907360
Orlić, Lucija
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Orlić, L. (2017). Mehanizmi bakterija kojim se stanice domaćina mogu prevesti u tumorske (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:907360

Orlić, Lucija. "Mehanizmi bakterija kojim se stanice domaćina mogu prevesti u tumorske." Undergraduate thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:907360

Orlić, Lucija. "Mehanizmi bakterija kojim se stanice domaćina mogu prevesti u tumorske." Undergraduate thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:907360

Orlić, L. (2017). 'Mehanizmi bakterija kojim se stanice domaćina mogu prevesti u tumorske', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:907360

Orlić L. Mehanizmi bakterija kojim se stanice domaćina mogu prevesti u tumorske [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:907360

L. Orlić, "Mehanizmi bakterija kojim se stanice domaćina mogu prevesti u tumorske", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:907360

Metadata
TitleMehanizmi bakterija kojim se stanice domaćina mogu prevesti u tumorske
Title (english)Bacterial mechanisms that can turn host cells into tumor cells
AuthorLucija Orlić
MentorIvana Ivančić Baće (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2017-09-07, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Sve je veći broj istraživanja koja dovode u vezu određene bakterijske vrste i rizik od nastanka raka. Prilikom infekcije, da bi preživjele i razmnožile se, patogene bakterije potiču niz promjena u domaćinskim stanicama. Pritom često dolazi do oštećenja molekule DNA. Različiti faktori virulencije onemogućuju cjelovit odgovor stanice na oštećenje DNA; većina bakterija, poput H. pylori, smanjuje razinu tumor supresora p53, a Listeria monocytogenes uzrokuje degradaciju proteina Mre11. Bakterije također mogu utjecati na signalne puteve stanice. H. pylori, Salmonella enterica i Fusobacterium nucleatum aktiviraju signalni put Wnt/β-katenin koji može dovesti do aktivacije gena uključenih u onkogenezu. Signalni putevi MAPK i Akt kontroliraju proliferaciju i apoptozu, a na njihovu regulaciju utječu S. enterica, H. pylori i C. trachomatis. Ovi mehanizmi doprinose razvoju raka jer mogu dovesti stanice domaćina korak bliže transformaciji. Veći je rizik kod kroničnih infekcija jer je organizam izložen takvom utjecaju kroz duži vremenski period.
Abstract (english)
A growing number of research is finding a connection between certain species of bacteria and the risk of cancer development. During infection, to survive and proliferate, pathogenic bacteria induce a series of changes in host cells. Simultaneously, DNA damage often occurs. Various virulence factors can disrupt DNA damage response; most bacteria, such as H. pylori, downregulate tumor suppressor p53, while Listeria monocytogenes causes Mre11 degradation. Bacteria can also affect cell signaling. H. pylori, Salmonella enterica and Fusobacterium nucleatum activate Wnt/β-catenin signal pathway which can lead to activation of genes involved in oncogenesis. MAPK and Akt signal pathways control cell proliferation and apoptosis, and they are regulated by S. enterica, H. pylori and C. trachomatis. These mechanisms contribute to cancer development because they can bring host cells one step closer to transformation. Chronic infections bring greater risk because the organism is exposed to such influence over a longer period of time.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:907360
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-09-19 07:11:48