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undergraduate thesis
Novi pristupi u dokidanju otpornosti stanica tumora na kemoterapiju
Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:870147
Sudarević, Antonija
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Sudarević, A. (2017). Novi pristupi u dokidanju otpornosti stanica tumora na kemoterapiju (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:870147

Sudarević, Antonija. "Novi pristupi u dokidanju otpornosti stanica tumora na kemoterapiju." Undergraduate thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:870147

Sudarević, Antonija. "Novi pristupi u dokidanju otpornosti stanica tumora na kemoterapiju." Undergraduate thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:870147

Sudarević, A. (2017). 'Novi pristupi u dokidanju otpornosti stanica tumora na kemoterapiju', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:870147

Sudarević A. Novi pristupi u dokidanju otpornosti stanica tumora na kemoterapiju [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:870147

A. Sudarević, "Novi pristupi u dokidanju otpornosti stanica tumora na kemoterapiju", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:870147

Metadata
TitleNovi pristupi u dokidanju otpornosti stanica tumora na kemoterapiju
Title (english)New approches in overcoming cancer cell resistance to chemotherapy
AuthorAntonija Sudarević
MentorNada Oršolić (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2017, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Različite vrste tumora danas su jedan od vodećih uzroka smrtnosti u svijetu. Tumorske stanice imaju sposobnost nekontroliranog, autonomnog i neograničenog rasta te su kao posljedica genetičke nestabilnosti razvile broje mehanizme otpornosti na tradicionalne oblike liječenja. Otpornost stanica tumora na kemoterapiju glavni je problem liječenja protutumorskim lijekovima, stoga se u današnje vrijeme sve više istražuju nove metode kojima bi se to spriječilo, a samim time i povećala uspješnost izlječenja. U ovom radu izložen je kratki pregled nekih od novih pristupa, u prevladavanju otpornosti tumorskih stanica- korištenje nanočestica, imunoterapije i biljnih polifenola. Takvi novi pristupi djeluju na mehanizme otpornosti kao što su povećano izbacivanja lijeka iz stanice, smanjenje unosa lijeka u stanicu, smanjenje vezanja protutumorskih lijekova na ciljne molekule unutar stanice te aktivacija signalnih puteva koji inhibiraju apoptozu. Metode navedene u ovom radu zahtijevaju dodatna ispitivanja i usavršavanja kako bi se u skorijoj budućnosti mogle efikasno koristiti za liječenje različitih oblika tumora.
Abstract (english)
One of the leading causes of mortality in the world nowadays are different types of tumors. Tumor cells have the ability of uncontrolled, autonomous and unrestricted growth and as a result of their genetic instability, they have developed numerous mechanisms of resistance to traditional forms of treatment. The resistance of tumor cells to chemotherapy is a major problem in treatment with anti-inflammatory drugs, so new methods are being explored to prevent this and thus increase the success of the treatment. In this paper , a short review of some of the new approaches in overcoming the resistance of tumor cells such as using nanoparticles, immunotherapy and plant polyphenols, has been presented. These new approaches act on the resistance mechanisms such as increased activity of drug efflux , reduced drug intake, reduced binding of anti-inflammatory drugs to the target molecules within the cell, and activation of signal pathways that inhibit apoptosis. The methods outlined in this paper require further examinations and enhancements to be able to efficiently use in the near future to treat various types of tumors.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:870147
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-10-10 07:18:57