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master's thesis
Teorija gubitka kromosoma u stanicama različite ploidije
Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:949180
Jelenić, Ivan
University of Zagreb
Faculty of Science
Department of Physics

Institutional repository: Repository of the Faculty of Science

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Jelenić, I. (2017). Teorija gubitka kromosoma u stanicama različite ploidije (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:949180

Jelenić, Ivan. "Teorija gubitka kromosoma u stanicama različite ploidije." Master's thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:949180

Jelenić, Ivan. "Teorija gubitka kromosoma u stanicama različite ploidije." Master's thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:949180

Jelenić, I. (2017). 'Teorija gubitka kromosoma u stanicama različite ploidije', Master's thesis, University of Zagreb, Faculty of Science, accessed 18 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:949180

Jelenić I. Teorija gubitka kromosoma u stanicama različite ploidije [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2024 November 18] Available at: https://urn.nsk.hr/urn:nbn:hr:217:949180

I. Jelenić, "Teorija gubitka kromosoma u stanicama različite ploidije", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:949180

Metadata
TitleTeorija gubitka kromosoma u stanicama različite ploidije
Title (english)Theory for chromosome loss in cells of different ploidy
AuthorIvan Jelenić
MentorNenad Pavin (mentor)
Committee memberNenad Pavin (predsjednik povjerenstva)
Committee memberMirko Planinić (član povjerenstva)
Committee memberDanko Radić (član povjerenstva)
Committee memberMihael Grbić (član povjerenstva)
Committee memberMatko Milin (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Physics)
Zagreb
Defense date and country2017-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Abstract
Korištenjem poznatih podataka o dijelovima i procesima u stanici tokom diobe, postavili smo model dinamike između populacija stanica u raznim djelovima prometafaze, metafaze i anafaze. Rješavanjem pojednostavljenog modela uvidjeli smo važnost uvođenja vremenskog limita, kojeg uvodimo u obliku spindle assembly checkpoint-a (SAC-a). Rješavanjem općenitog modela uviđamo da populacije stanica sa više kromosoma sporije napreduju u formiranju diobenog vretena. Takve stanice kasne u metafazu i anafazu te imaju veći gubitak kromosoma. Ispitali smo neke od važnijih ili manje poznatih parametara kako bi ustanovili njihov utjecaj na trajanje formiranja diobenog vretena te gubitak kromosoma. Trajanje formiranja diobenog se povećalo sa povećanjem broja kromosoma i za male iznose parametra 𝛼, koji označava odnos broja mikrotubula i kromosoma, dok je geometrija stanica manje utjecajna. Nadalje smo ispitali parametre vezane za SAC te ustanovili važnost i utjecaj na gubitak kromosoma.
Abstract (english)
Using known information and data about cell parts and processes during cellular division, we made a model of population dynamics between cells in different stages of prometaphase, metaphase and anapahase. By solving the simplified model, we saw the importance of introducing a time limit, which we introduce in the form of the spindle assembly chepoint and the time where cells skip it. We solved the general model and found that populations of cells with more chromosomes form the spindle more slowly, and are thus late into metaphase and anaphase, and have a higher chomosome loss. We examined some of the more important or unknown parameters to find how they infulence the duration of the spindle assembly and chromosome loss. The duration of spindle assembly increases with the increase in the number of chromosomes in a cell, and with smaller values of the parameter 𝛼, which comes from the relation between the number of microtubules and chromosomes. The geometry affects the duration of spindle assembly less than the already listed parameters. Furthermore, we examined the parameters involved in modelling SAC, and determined their importance on chromosome loss.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:949180
Study programmeTitle: Physics; specializations in: Research
Course: Research
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra fizike (magistar/magistra fizike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2019-10-10
Terms of useLicence In copyright icon
Created on2017-10-13 12:23:34