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doctoral thesis
Utjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom
Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:505019
Vazdar, Ljubica
University of Zagreb
Faculty of Science

Institutional repository: Repository of the Faculty of Science

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Vazdar, Lj. (2017). Utjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:505019

Vazdar, Ljubica. "Utjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom." Doctoral thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:505019

Vazdar, Ljubica. "Utjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom." Doctoral thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:505019

Vazdar, Lj. (2017). 'Utjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 23 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:505019

Vazdar Lj. Utjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2024 November 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:505019

Lj. Vazdar, "Utjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:505019

Metadata
TitleUtjecaj polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom
Title (english)Influence of HER-2/neu gene polymorphism on monoclonal antibody trastuzumab induced cardiotoxicity
AuthorLjubica Vazdar
MentorHrvoje Pintarić (mentor)
MBZ: 224771
Committee memberSonja Levanat (predsjednik povjerenstva)
Committee memberAna Galov (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
Zagreb
Defense date and country2017, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		57 - Biological sciences. Physical anthropology. Biodiversity
Abstract
Malobrojna dosadašnja istraživanja pokazala su dvojbene rezultate utjecaja polimorfizma gena HER-2/neu na kardiotoksičnost uzrokovanu monoklonskim protutijelom trastuzumabom. Obzirom na izuzetno važan biljeg u onkologiji i mogući čimbenik rizika srčanog oštećenja, nametnula se potreba ovakvog istraživanja. U istraživanje su uključene ispitanice adjuvantno liječene trastuzumabom zbog HER2 pozitivnog ranog raka dojke (n=177). Ispitanice su podijeljenje u dvije grupe: grupa A (n=99) kod kojih nije došlo do kardiotoksičnosti tijekom liječenja trastuzumabom i grupa B (n=78) kod kojih je došlo do razvoja kardiotoksičnosti. Istraženi su rizični čimbenici kao i osobitosti same kardiotoksičnosti, vrijeme pojavnosti i oporavka te reverzibilnost. Svim ispitanicama je lančanom reakcijom polimeraze određen polimorfizam gena HER-2/neu na kodonu 655 [Ile655Val] te distribucija genotipa Ile/Val, Ile/Ile i Val/Val. Praćenje srčane funkcije ehokardiografijom bilo je u skladu s usvojenim smjernicama praćenja. Iz rezultata dobivenih usporedbom grupa A i B nije nađena povezanost između pojedinog genotipa HER-2/neu i pojave kardiotoksičnosti.
Abstract (english)
A few studies so far have shown doubtful results on influence of HER-2/ neu gene polymorphism on cardiotoxicity caused by monoclonal antibody trastuzumab. Remarkable importance of this marker in oncology and its place as a possible risk factor for cardial damage, imposed the need for this kind of research. The study included patients adjuvantly treated with trastuzumab for HER2 positive breast cancer (n = 177). Subjects were divided into two groups: group A (n = 99), which did not experience cardiotoxicity during treatment with trastuzumab and group B (n = 78) which did. Risk factors were investigated as well as the characteristics of cardiotoxicity, time of occurrence and recovery, and reversibility. Polymorphism of the HER-2/ neu gene on codon 655 [Ile655Val] and Ile/Val, Ile/Ile and Val/Val genotype distribution was determined by polimerase chain reaction in all patients. Heart function monitoring with echocardiography was consistent with the adopted monitoring guidelines. From the results obtained by comparing groups A and B, no correlation was found between HER-2/neu genotype and cardiotoxicity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:505019
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-11-02 12:41:43