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master's thesis
Priprava kvaternih soli benzimidazolijevih N-Mannichovih baza. Kondenzacijske reakcije i nastava kemije
Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:518770
Žunić, Hrvoje
University of Zagreb
Faculty of Science
Department of Biology
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Žunić, H. (2017). Priprava kvaternih soli benzimidazolijevih N-Mannichovih baza. Kondenzacijske reakcije i nastava kemije (Master's thesis). Zagreb: University of Zagreb, Faculty of Science; Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:518770

Žunić, Hrvoje. "Priprava kvaternih soli benzimidazolijevih N-Mannichovih baza. Kondenzacijske reakcije i nastava kemije." Master's thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:518770

Žunić, Hrvoje. "Priprava kvaternih soli benzimidazolijevih N-Mannichovih baza. Kondenzacijske reakcije i nastava kemije." Master's thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:518770

Žunić, H. (2017). 'Priprava kvaternih soli benzimidazolijevih N-Mannichovih baza. Kondenzacijske reakcije i nastava kemije', Master's thesis, University of Zagreb, Faculty of Science; University of Zagreb, Faculty of Science, accessed 27 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:518770

Žunić H. Priprava kvaternih soli benzimidazolijevih N-Mannichovih baza. Kondenzacijske reakcije i nastava kemije [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2024 May 27] Available at: https://urn.nsk.hr/urn:nbn:hr:217:518770

H. Žunić, "Priprava kvaternih soli benzimidazolijevih N-Mannichovih baza. Kondenzacijske reakcije i nastava kemije", Master's thesis, University of Zagreb, Faculty of Science, Zagreb; University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:518770

Metadata
TitlePriprava kvaternih soli benzimidazolijevih N-Mannichovih baza. Kondenzacijske reakcije i nastava kemije
Title (english)Synthesis of quaternary salts of benzimidazlium N-Mannich bases. Condensation reactions and teaching chemistry
AuthorHrvoje Žunić
MentorVesna Petrović Peroković (mentor)
MentorNenad Judaš (mentor)
Committee memberVesna Petrović Peroković (predsjednik povjerenstva)
Committee memberNenad Judaš (član povjerenstva)
Committee memberMirela Sertić Perić (član povjerenstva)
Committee memberMirjana Pavlica (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2017-10-03, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
U okviru istraživačkog dijela ovog diplomskog rada opisane su priprave novih kvaternih soli N-Mannichovih baza (5-10). Sinteza samih N-Mannichovih baza (1-3) uključuje trikomponentnu otopinsku reakciju paraformaldehida, benzimidazola ili imidazola te nikotinamida odnosno o-aminopiridina. Produkti nastali kondenzacijskom reakcijom benzimidazola, paraformaldehida i nikotinamida ili o-aminopiridina, spojevi 1 i 2, kvaternizirani su dodatkom halogenalkana dugih lanaca (1-bromdodekana, 1-bromtetradekana te 1-bromheksadekana) pri čemu su dobivene kvaterne soli 5-10. Strukture i čistoće svih pripravljenih spojeva potvrđene su standardnim spektroskopskim analitičkim postupcima (IR, NMR, MS). U metodičkom dijelu rada osmišljen je prijedlog nastavnog sata na temu „Kondenzacijske reakcije i nastava kemije“. Glavni problem ove nastavne teme jest da se učenici susreću s kondenzacijskim reakcijama u udžbenicima bez da su ih sami izveli. Prijedlog nastavnog sata temelji se na strategiji učenja otkrivanjem i sadrži pokus kojim se omogućuje da učenici uz pomoć nastavnika i uputa s radnog listića otkriju produkt kondenzacijske reakcije između acetona i benzaldehida.
Abstract (english)
Within the research part of this thesis, the preparation methods of new quaternary salts of N-Mannich bases were described. The synthesis of all Mannich bases (1-3) includes a three-component „one-pot“ solvent synthesis combining paraformaldehyde, benzimidazole/imidazole and nicotinamide/o-aminopyridine. The final products, compounds 1 and 2, which were prepared in condensation reactions using benzimidazole, parafomaldehyde and nicotinamide/o-aminopyridine, were used in quaternization reactions with appropriate alkyl halides (1-bromododecane, 1-bromotetradecane and 1-bromohexadecane). The structures and purity of all prepared compounds were characterized and determined by standard analytical methods (IR, NMR, MS). In the methodical part of this thesis, a chemistry lesson on topic "Condensation reactions and chemistry class" was proposed. The main problem of this topic is that students meet condensation reactions in textbooks without doing the experiment in the lab. This lesson is based on the inquiry learning strategy and contains an experiment that allows students to synthesize the product of condensation reaction between acetone and benzaldehyde, with teachers guidance and worksheet instructions.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:518770
Study programmeTitle: Integrated undergraduate and graduate university study of Biology and Chemistry Education; specializations in: Integrated undergraduate and graduate university study of Biology and Chemistry Education
Course: Integrated undergraduate and graduate university study of Biology and Chemistry Education
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra edukacije biologije i kemije (magistar/magistra edukacije biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2019-10-03
Terms of useLicence In copyright icon
Created on2017-11-13 08:16:31