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undergraduate thesis
Poli(ADP-ribozil) polimeraza u životu i smrti živčanih stanica
Zagreb: University of Zagreb, Faculty of Science, 2014. urn:nbn:hr:217:330498
Ahel, Josip
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Ahel, J. (2014). Poli(ADP-ribozil) polimeraza u životu i smrti živčanih stanica (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:330498

Ahel, Josip. "Poli(ADP-ribozil) polimeraza u životu i smrti živčanih stanica." Undergraduate thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:330498

Ahel, Josip. "Poli(ADP-ribozil) polimeraza u životu i smrti živčanih stanica." Undergraduate thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:330498

Ahel, J. (2014). 'Poli(ADP-ribozil) polimeraza u životu i smrti živčanih stanica', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 03 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:330498

Ahel J. Poli(ADP-ribozil) polimeraza u životu i smrti živčanih stanica [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2014 [cited 2024 May 03] Available at: https://urn.nsk.hr/urn:nbn:hr:217:330498

J. Ahel, "Poli(ADP-ribozil) polimeraza u životu i smrti živčanih stanica", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:217:330498

Metadata
TitlePoli(ADP-ribozil) polimeraza u životu i smrti živčanih stanica
Title (english)Poly(ADP-ribosyl) polymerase in life and death of neural cells
AuthorJosip Ahel
MentorMaja Matulić (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2014, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Poli(ADP riboza) je post-translacijska modifikacija proteina koju iz NAD+ sintetiziraju proteini iz obitelji Poli(ADP-ribozil) polimeraza. Poli(ADP-ribozil)acija je reverzibilna reakcija te povratnu reakciju katalizira nekolicina specifičnih enzima. Poli(ADPribozil) acijski sustavi su prisutni u svim eukariotskim supergrupama. U ovom se radu nudi pregled dosadašnjih saznanja o ulogama poli(ADP-ribozil)acije u popravku DNA, reorganizaciji kromatina, regulaciji transkripcije te nekrozi i apoptozi, s posebnim osvrtom na učinke poli(ADP-ribozil)acije u živčanom sustavu. Poli(ADP-ribozil) polimeraze ključan su medijator u tim procesima regulirajući aktivnost čitavog niza proteina koji su direktno uključeni u spomenute procese i to stvaranjem skela poli(ADP riboze) ili direktnom modifikacijom ciljnih proteina. Nadalje, pretjerana aktivnosti poli(ADP-ribozil) polimeraza može dovesti do nekrotične smrti stanica uslije energetskog šoka ili parthanatosa uslijed translokacije mitohondrijskih signala smrti. Do pretjerane aktivacije poli(ADP-ribozil) polimeraza u živčanom sustavu može doći uslijed ekscitotoksičnog djelovanja glutamata te akutnih oboljenja poput moždanog udara i traumatskih ozljeda, kada dolazi do oksidativnog stresa, značajne aktivacije upalnih procesa te neurodegeneracije uz posredovanje poli(ADPribozil) polimeraze. Postoje indikacije da poli(ADP-ribozil) polimeraza ima ulogu u patologiji Parkinsonove i Alzheimerove bolesti. U svim spomenutim procesima bitnu ulogu vjerojatno također imaju i glikohidrolaza terminalne ADP riboze te poli(ADP-ribozil) glikohidrolaza, koje su puno slabije istražene, no učinak disfunkcije ovih proteina na živčani sustav naglašava njihovu važnu ulogu u istom.
Abstract (english)
Poly(ADP-ribose) is a post-translational modification of proteins synthesized by the poly(ADP-ribosyl) polimerase family enzymes from NAD+. Poly(ADP-ribosyl)ation is a reversible reaction with specific enzymes catalysing the hydrolysis of poly(ADP-ribose). Poly(ADP-ribosyl)ation systems are found in all six eukaryotic supergroups. In this paper, I offer a review of up-to-date findings about the roles of poly(ADP-ribosyl)ation in DNA repair, chromatin reoragnization, transcription regulation, necrosis and apoptosis, with emphasis on the function of poly(ADP-ribosyl)ation in the nervous system. In these processes, poly(ADP-ribosyl) polimerases play a key role regulating the activity of numerous proteins directly engaged in these processes. This is achieved by forming poly(ADP-ribose) scaffolds or by direct modification of target proteins. Moreover, excessive poly(ADP-ribosyl) polimerase activity may lead to necrotic cell death by energy shock or to parthanatos caused by translocation of mitochondrial death signals. In the nervous system, excessive poly(ADPribosyl) polimerase activity can be caused by the excitotoxic action of glutamate and by acute conditions, such as stroke and traumatic injuries, during which cells experience oxidative stress, significant activation of inflammatory processes and poly(ADP-ribosyl) polimerasemediated neurodegeneration. Poly(ADP-ribosyl) glycohydrolase and terminal (ADP-ribose) glycohydrolase most likely also play significant roles in the aforementioned processes as disfunctionality in these two proteins has severe neurodegenerative effects.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:330498
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2017-12-06 09:37:34