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undergraduate thesis
Utjecaj mikroba na terapije tumora
Zagreb: University of Zagreb, Faculty of Science, 2014. urn:nbn:hr:217:061362
Čulo, Anja
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Čulo, A. (2014). Utjecaj mikroba na terapije tumora (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:061362

Čulo, Anja. "Utjecaj mikroba na terapije tumora." Undergraduate thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:061362

Čulo, Anja. "Utjecaj mikroba na terapije tumora." Undergraduate thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:061362

Čulo, A. (2014). 'Utjecaj mikroba na terapije tumora', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:061362

Čulo A. Utjecaj mikroba na terapije tumora [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2014 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:061362

A. Čulo, "Utjecaj mikroba na terapije tumora", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:217:061362

Metadata
TitleUtjecaj mikroba na terapije tumora
Title (english)The impact of microbes on tumor therapies
AuthorAnja Čulo
MentorIvana Ivančić Baće (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2014, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Ljudsko tijelo je dom za 10 14 mikroba i 10 15 virusa. Mikrobi naseljavaju sve površine tijela koje su u dodiru s okolišem. Održavanje stalnog sastava mikrobnih populacija je važno za zdravlje čovjeka. Duga koevolucija dovela je do složenih interakcija između ljudskog imunološkog sustava i simbiotskih mikroba. U odsustvu pojedinih vrsta mikroba, imunološki sustav se neće normalno razviti. Neke terapije tumora stimuliraju naš imunološki sustav. Upalni odgovori igraju odlučujuću u različitim fazama razvoja tumora i u reakcijama tumora na terapije. Nedavna istraživanja na miševima su pokazala da mikrobi u probavilu utječu na nekoliko vrsta antitumorski terapije koje se često koriste u liječenju čovjeka: imunoterapiju CpG-oligonukleotidima i kemoterapije spojevima platine, ciklofosfamidom i kampotekinom. Pacijenti obično nakon terapije dobivaju antibiotike kako bi se spriječile infekcije do kojih dolazi zbog oslabljenog imunološkog sustava. Upotreba antibiotika dovodi do smanjenja broja određenih bakterija što rezultira smanjenom učinkovitošću terapije. Ovi rezultati bi mogli imati veliki utjecaj na terapije tumora u budućnosti.
Abstract (english)
Human body is home to 10 14 microbes i 10 15 viruses. Microbes colonize all of the surfaces of the body that are exposed to the environment. It is important for human health to maintain constant composition of microbial populations. Long coevolution has led to complex interactions between human immune system and symbiotic microbes. In the absence of certain species of microbes, immune system will not develop normally. Some tumor therapies stimulate our immune system. Inflammatory responses play decisive roles at different stages of tumor development and reactions to therapy. Recent studies on mice showed that gut microbes affect few types of antitumor therapies which are often used in human treatment: CpG-oligonucleotide immunotherapy and platinum, cyclophosphamide and campothecin chemotherapy. Cancer patients usually get antibiotics after therapy to prevent possible infections due to weakened immune system. The use of antibiotics reduces the number of certain bacteria which results in decreased therapy efficiency. These findings could have major impact on tumor therapies in the future.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:061362
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2017-12-06 12:50:21