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master's thesis
Antioksidativni i fitoestrogeni učinak ikarina na osteoporozu štakora izazvanu retinoičnom kiselinom
Zagreb: University of Zagreb, Faculty of Science, 2017. urn:nbn:hr:217:550706
Tarabene, Matea
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Tarabene, M. (2017). Antioksidativni i fitoestrogeni učinak ikarina na osteoporozu štakora izazvanu retinoičnom kiselinom (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:550706

Tarabene, Matea. "Antioksidativni i fitoestrogeni učinak ikarina na osteoporozu štakora izazvanu retinoičnom kiselinom." Master's thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:550706

Tarabene, Matea. "Antioksidativni i fitoestrogeni učinak ikarina na osteoporozu štakora izazvanu retinoičnom kiselinom." Master's thesis, University of Zagreb, Faculty of Science, 2017. https://urn.nsk.hr/urn:nbn:hr:217:550706

Tarabene, M. (2017). 'Antioksidativni i fitoestrogeni učinak ikarina na osteoporozu štakora izazvanu retinoičnom kiselinom', Master's thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:550706

Tarabene M. Antioksidativni i fitoestrogeni učinak ikarina na osteoporozu štakora izazvanu retinoičnom kiselinom [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2017 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:550706

M. Tarabene, "Antioksidativni i fitoestrogeni učinak ikarina na osteoporozu štakora izazvanu retinoičnom kiselinom", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:217:550706

Metadata
TitleAntioksidativni i fitoestrogeni učinak ikarina na osteoporozu štakora izazvanu retinoičnom kiselinom
Title (english)Antioxidative and phytoestrogen effect of icarin on retinoic acid inuced osteoporosis in rats
AuthorMatea Tarabene
MentorNada Oršolić (mentor)
Committee memberNada Oršolić (predsjednik povjerenstva)
Committee memberPetra Korać (član povjerenstva)
Committee memberSunčica Bosak (član povjerenstva)
Committee memberDuje Lisičić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2017-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Osteoporoza je bolest koštanog tkiva koju karakterizira smanjenje mase kostiju što ih čini podložnijima lomovima. Brojni podaci ukazuju da flavonoidi uključujući ikarin imaju snažna antioksidativna, fitoestrogenska i antiosteoporotska svojstva. Temeljem navedenog glavni ciljevi ovog istraživanja bili su: (i) izazvati osteoporozu kod štakora visokim dozama retinoične kiseline (model osteoporoze; RMO), (ii) utvrditi učinak ikarina kao terapeutika osteoporoze u RMO, (iii) usporediti učinak ikarina s komercijalnim lijekom–alendronatom, (iv) istražiti antioksidativnu sposobnost ikarina na stanicama jajnika, (v) utvrditi učinak ikarina na koštani sustav RMO i zdravih štakora te (vi) usporediti genotoksičnost ikarina i alendronata na RMO i zdravim štakorima. Rezultati ukazuju da ikarin povećava masu kostiju i maternice kao i mineralnu gustoću kostiju kroz antioksidativnu i estrogensku aktivnost. Ikarin pokazuje manji genotoksični učinak od alendronata.
Abstract (english)
Osteoporosis is a bone disease characterized by low bone mass which makes the bones susceptible to fractures. Icariin is a type of flavonoid that promotes osteocyte differentiation and inhibits the formation of osteoclasts which lowers the bone resorption rate. Numerous data indicate that flavonoids including icariin have strong antioxidant, phytoestrogen and antiosteoporotic properties. The main objectives of this thesis are: (i) promoting osteoporosis in rats with high dosis of retinoic acid, (ii) evaluating icariin's ability as a therapeutic in RMO, (iii) comparing the effects of icariin to a commercial drug-alendronate, (iv) investigating icariin's antioxidative abilities on the ovaries, (v) assessing icariin's effect on the skeletal system of RMO and healthy rats as well as (vi) comparing the genotoxicity of icariin and alendronate in RMO and healthy rats. Our results indicate that icariin increases bone mass and mass of uterus, as well as bone mineral density through antioxidant and estrogenic activity. Icarin shows smaller genotoxic effects of alendronate.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:550706
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-12-07 09:27:48