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undergraduate thesis
Uloga telomernog područja u starenju i bolestima čovjeka
Zagreb: University of Zagreb, Faculty of Science, 2014. urn:nbn:hr:217:961832
Prepeluh, Ivan
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Prepeluh, I. (2014). Uloga telomernog područja u starenju i bolestima čovjeka (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:961832

Prepeluh, Ivan. "Uloga telomernog područja u starenju i bolestima čovjeka." Undergraduate thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:961832

Prepeluh, Ivan. "Uloga telomernog područja u starenju i bolestima čovjeka." Undergraduate thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:961832

Prepeluh, I. (2014). 'Uloga telomernog područja u starenju i bolestima čovjeka', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:961832

Prepeluh I. Uloga telomernog područja u starenju i bolestima čovjeka [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2014 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:217:961832

I. Prepeluh, "Uloga telomernog područja u starenju i bolestima čovjeka", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:217:961832

Metadata
TitleUloga telomernog područja u starenju i bolestima čovjeka
Title (english)The role of telomeric sequence in ageing and human diseases
AuthorIvan Prepeluh
MentorVlatka Zoldoš (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2014, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Krajevi kromosoma čovjeka i ostalih eukariota završavaju telomerama, koje imaju ključnu ulogu u očuvanju stabilnosti cijelog genoma. Eukariotski kromosomi su linearne strukture te prilikom replikacije njihovih telomera u svakoj mitotskoj diobi dolazi do gubitka dijela telomerne sekvence. Kada duljine telomera dosegnu kritičnu točku (Hayflickov limit), stanica se više ne dijeli te ulazi u fazu starenja (eng. senescence) ili ulazi u proces stanične smrti (apoptoza). Skraćivanje telomera štiti stanicu od maligne transformacije, smanjujući potencijal stanice da se dijeli, no isto tako smanjenjem duljine, telomere gube svoju funkciju te može doći do nastanka malignog fenotipa. Maligne stanice imaju vječni replikacijski potencijal zahvaljujući enzimu telomerazi koji služi kao kalup za produljivanje lanca bogatog G-nukleotidima. Telomerno područje ne sadrži gene, no njegovim nestankom dolazi do razaranja stukture subtelomernog područja koje je bogato genima. Oštećenjem DNA subtelomernog područja dolazi do raznih mutacija u genima koje imaju kao posljedicu nastanak raznih bolesti i abnormalnih fenotipova.
Abstract (english)
The ends of human and eukaryotic chromosomes terminate with telomeres, which play the key role in preserving the stability of the entire genome. Eukaryotic chromosomes are linear structures and during replication of their telomeras in each mitotic division, a part of their telomeric sequence is lost. When telomere length reaches a critical point (Hayflick limit), the cell no longer divides and enteres the phase of ageing (senescence) or enteres the process of cell death (apoptosis). Shortening of telomeres protects the cell from a malignant phenotype, reducing potential for cells to divide, however, with length loss, temorese lose their function and that can lead to the malignant phenotype. Malignant cells have eternal replication potential thanks to the telomerase enzyme that serves as a template for extending the chain of G-rich nucleotides. Telomeric area does not contain genes, but its disappearence leads to destruction of subtelomeric area which contains many genes. Because of damage in DNA of subtelomeric region there are many variety of mutations in genes that can occur and lead to various diseases and abnormal phenotypes.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:961832
Study programmeTitle: Environmental Sciences
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) struke znanosti o okolišu (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) struke znanosti o okolišu)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-12-11 09:31:21